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Oral cancer treatment

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Opinion statement

Oral cancer is the sixth most common cancer in the world, and it continues to represent a serious public health problem. Oral cancer is a preventable disease, related to behavioral and lifestyle factors, including tobacco and alcohol. Prevention and early detection of oral cancer remain the goals of national efforts to reduce the impact of this disease on the public. Surgical treatment is the mainstay of therapy for patients with oral cancer, particularly in advanced stages of cancer. External beam radiation therapy and brachytherapy have been used successfully as the primary modality for treating patients with early stage oral cancer, and they are the standard of care for use as adjuvant therapy in postoperative cases of patients with advanced stage oral cancer. There is an emerging trend for the use of chemotherapy in combination with radiation therapy and surgery for patients with advanced, recurrent, and metastatic head and neck cancer, although evidence is limited regarding survival benefit when used for treating patients with oral cavity carcinoma. Any report on the treatment of oral cancer is incomplete without consideration of functional and aesthetic outcomes, particularly addressing speech, swallowing, masticatory efficiency, and dental rehabilitation. Future generations will continue to fight these dreadful diseases until scientists and clinicians are provided the opportunities to expand efforts to prevent, detect (early), and eradicate oral and other head and neck cancers.

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References and Recommended Reading

  1. Ries LAG, Eisner MP, Kosary CL, et al.: SEER Cancer Statistics Review, 1973–1999. Bethesda: National Cancer Institute; 2002.

    Google Scholar 

  2. Shiboski CH, Shiboski SC, Silverman S Jr: Trends in oral cancer rates in the United States, 1973–1996? Community Dent Oral Epidemiol 2000, 28:249–256.

    Article  PubMed  CAS  Google Scholar 

  3. Patel V, Leethanakul C, Gutkind JS: New approaches to the understanding of the molecular basis of oral cancer? Crit Rev Oral Biol Med 2001, 12:55–63. An overview of recent advances in the molecular characterization of head and neck cancer, including the use of laser capture microdissection and DNA analysis techniques.

    PubMed  CAS  Google Scholar 

  4. Kim ES, Kies M, Herbst RS: Novel therapeutics for head and neck cancer? Curr Opin Oncol 2002, 14:334–342.

    Article  PubMed  CAS  Google Scholar 

  5. Funk GF, Karnell LH, Robinson RA, et al.: Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report? Head Neck 2002, 24:165–180.

    Article  PubMed  Google Scholar 

  6. Casiglia J, Woo SB: A comprehensive review of oral cancer? Gen Dent 2001, 49:72–82.

    PubMed  CAS  Google Scholar 

  7. Sisk EA, Zhu S, Fisher SG, et al.: Human papillomavirus and p53 mutational status as prognostic factors in head and neck carcinoma? Head Neck 2002, 24:841–849.

    Article  PubMed  Google Scholar 

  8. Day GL, Shore RE, Blot WJ, et al.: Dietary factors and second primary cancers: a follow-up of oral and pharyngeal cancer patients? Nutr Cancer 1994, 21:223–232.

    Article  PubMed  CAS  Google Scholar 

  9. Morse DE, Pendrys DG, Katz RV, et al.: Food group intake and the risk of oral epithelial dysplasia in a United States population? Cancer Causes Control 2000, 11:713–720.

    Article  PubMed  CAS  Google Scholar 

  10. Negri E, Franceschi S, Bosetti C, et al.: Selected micronutrients and oral and pharyngeal cancer? Int J Cancer 2000, 86:122–127.

    Article  PubMed  CAS  Google Scholar 

  11. Horowitz AM, Drury TF, Goodman HS, Yellowitz JA: Oral pharyngeal cancer prevention and early detection: dentists’ opinions and practices? J Am Dent Assoc 2000, 131:453–462.

    PubMed  CAS  Google Scholar 

  12. Sciubba JJ: Improving detection of precancerous and cancerous oral lesions: computer-assisted analysis of the brush biopsy. US Collaborative OralCDx Study Group? J Am Dent Assoc 1999, 130:1445–1457.

    PubMed  CAS  Google Scholar 

  13. Onofre MA, Sposto MR, Navarro CM: Reliability of toluidine blue application in the detection of oral epithelial dysplasia and in situ and invasive squamous cell carcinomas? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001, 91:535–540.

    Article  PubMed  CAS  Google Scholar 

  14. Portugal LG, Wilson KM, Biddinger PW, Gluckman JL: The role of toluidine blue in assessing margin status after resection of squamous cell carcinomas of the upper aerodigestive tract? Arch Otolaryngol Head Neck Surg 1996, 122:517–519.

    PubMed  CAS  Google Scholar 

  15. Epstein JB, Oakley C, Millner A, et al.: The utility of toluidine blue application as a diagnostic aid in patients previously treated for oropharyngeal carcinoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997, 83:537–547.

    Article  PubMed  CAS  Google Scholar 

  16. Lippman SM, Lee JJ, Karp DD, et al.: Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer? J Natl Cancer Inst 2001, 93:605–618.

    Article  PubMed  CAS  Google Scholar 

  17. Garewal HS, Katz RV, Meyskens F, et al.: Beta-carotene produces sustained remissions in patients with oral leukoplakia: results of a multicenter prospective trial? Arch Otolaryngol Head Neck Surg 1999, 125:1305–1310.

    PubMed  CAS  Google Scholar 

  18. Mellott A, Vokes E: Chemoprevention in head and neck cancer? Cancer Treat Res 2001, 106:221–235.

    PubMed  CAS  Google Scholar 

  19. Braakhuis BJ, Tabor MP, Leemans CR, et al.: Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions? Head Neck 2002, 24:198–206.

    Article  PubMed  Google Scholar 

  20. Jang SJ, Chiba I, Hirai A, et al.: Multiple oral squamous epithelial lesions: Are they genetically related? Oncogene 2001, 20:2235–2242.

    Article  PubMed  CAS  Google Scholar 

  21. Califano J, van der Riet P, Westra W, et al.: Genetic progression model for head and neck cancer: implications for field cancerization? Cancer Res 1996, 56:2488–2492.

    PubMed  CAS  Google Scholar 

  22. Boyle JO, Hakim J, Koch W, et al.: The incidence of p53 mutations increases with progression of head and neck cancer? Cancer Res 1993, 53:4477–4480.

    PubMed  CAS  Google Scholar 

  23. Forastiere A, Koch W, Trotti A, Sidransky D: Head and neck cancer? N Engl J Med 2001, 345:1890–1900. Well-organized comprehensive review of head and neck cancer pathogenesis and treatment.

    Article  PubMed  CAS  Google Scholar 

  24. Shintani S, Kiyota A, Mihara M, et al.: Association of preoperative radiation effect with tumor angiogenesis and vascular endothelial growth factor in oral squamous cell carcinoma? Jpn J Cancer Res 2000, 91:1051–1057.

    PubMed  CAS  Google Scholar 

  25. Semenza G: HIF-1 and tumor progression: pathophysiology and therapeutics? Trends Mol Med 2002, 8:S62-S67.

    Article  PubMed  CAS  Google Scholar 

  26. Sudbo J, Kildal W, Risberg B, et al.: DNA content as a prognostic marker in patients with oral leukoplakia? N Engl J Med 2001, 344:1270–1278.

    Article  PubMed  CAS  Google Scholar 

  27. Zhang L, Rosin MP: Loss of heterozygosity: a potential tool in management of oral premalignant lesions? J Oral Pathol Med 2001, 30:513–520.

    Article  PubMed  CAS  Google Scholar 

  28. Greene FL, Page DL, Fleming ID, et al.: Cancer Staging Manual. New York: Springer-Verlag; 2002.

    Google Scholar 

  29. Zieron JO, Lauer I, Remmert S, Sieg P: Single photon emission tomography: scintigraphy in the assessment of mandibular invasion by head and neck cancer? Head Neck 2001, 23:979–984.

    Article  PubMed  CAS  Google Scholar 

  30. Don DM, Anzai Y, Lufkin RB, et al.: Evaluation of cervical lymph node metastases in squamous cell carcinoma of the head and neck? Laryngoscope 1995, 105:669–674.

    Article  PubMed  CAS  Google Scholar 

  31. Robbins KT, Clayman G, Levine PA, et al.: Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery? Arch Otolaryngol Head Neck Surg 2002, 128:751–758.

    PubMed  Google Scholar 

  32. Mukherji SK, Castelijns J, Castillo M: Squamous cell carcinoma of the oropharynx and oral cavity: how imaging makes a difference? Semin Ultrasound CT MR 1998, 19:463–475.

    Article  PubMed  CAS  Google Scholar 

  33. Mukherji SK, Isaacs DL, Creager A, et al.: CT detection of mandibular invasion by squamous cell carcinoma of the oral cavity? AJR Am J Roentgenol 2001, 177:237–243. The use of CT scanning in assessing mandibular involvement, thus staging of oral cancer is well described in this article.

    PubMed  CAS  Google Scholar 

  34. Shaha AR: Preoperative evaluation of the mandible in patients with carcinoma of the floor of mouth? Head Neck 1991, 24:398–402.

    Article  Google Scholar 

  35. Weber AL, Scrivani SJ: Mandible: anatomy, cysts, tumors, and non-tumorous lesions. In Head and Neck Imaging. Edited by Som CH. St. Louis: Mosby; 1996:320–323.

    Google Scholar 

  36. Nakasone Y, Inoue T, Oriuchi N, et al.: The role of whole-body FDG-PET in preoperative assessment of tumor staging in oral cancers? Ann Nucl Med 2001, 15:505–512.

    Article  PubMed  CAS  Google Scholar 

  37. Mukherji SK, Drane WE, Mancuso AA, et al.: Occult primary tumors of the head and neck: detection with 2-[F-18] fluoro-2-deoxy-D-glucose SPECT? Radiology 1996, 199:761–766.

    PubMed  CAS  Google Scholar 

  38. Anzai Y, Carroll WR, Quint DJ, et al.: Recurrence of head and neck cancer after surgery or irradiation: prospective comparison of 2-deoxy-2-[F-18]fluoro-Dglucose PET and MR imaging diagnoses? Radiology 1996, 200:135–141.

    PubMed  CAS  Google Scholar 

  39. Stoeckli SJ, Steinert H, Pfaltz M, Schmid S: Is there a role for positron emission tomography with 18F-fluorodeoxyglucose in the initial staging of nodal negative oral and oropharyngeal squamous cell carcinoma? Head Neck 2002, 24:345–349.

    Article  PubMed  Google Scholar 

  40. Neville B, Day T: Oral cancer and precancerous lesions? CA Cancer J Clin 2002, 32:195–215.

    Google Scholar 

  41. Pindborg JJ, Renstrup G, Poulsen HE, et al.: Studies in oral leukoplakia - V. Clinical and histologic signs of malignancy? Acta Odontol Scand 1963, 21:407–414.

    PubMed  CAS  Google Scholar 

  42. Silverman S Jr, Gorsky M, Lozada F: Oral leukoplakia and malignant transformation: a follow-up study of 257 patients? Cancer 1984, 53:563–568.

    Article  PubMed  Google Scholar 

  43. Silverman S Jr, Gorsky M: Proliferative verrucous leukoplakia: a follow-up study of 54 cases? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997, 84:154–157.

    Article  PubMed  Google Scholar 

  44. Shafer WG, Waldron CA: Erythroplakia of the oral cavity? Cancer 1975, 36:1021–1028.

    Article  PubMed  CAS  Google Scholar 

  45. Russolo M, Giacomarra V, Papanikolla L, Tirelli G: Prognostic indicators of occult metastases in oral cancer? Laryngoscope 2002, 112:1320–1323.

    Article  PubMed  Google Scholar 

  46. Yuen A, Lam KY, Wei WI, et al.: A comparison of the prognostic significance of tumor diameter, length, width, thickness, area, volume, and clinicopathologic features of oral tongue carcinoma? Am J Surg 2000, 180:139–143. Supports the concept of tumor thickness as an important prognostic indicator in consideration of adjuvant therapy for tongue cancer.

    Article  PubMed  CAS  Google Scholar 

  47. Bundgaard T, Bentzen SM, Wildt J, et al.: Histopathologic, stereologic, epidemiologic, and clinical parameters in the prognostic evaluation of squamous cell carcinoma of the oral cavity? Head Neck 1996, 18:142–152.

    Article  PubMed  CAS  Google Scholar 

  48. Gluckman JL, Pavelic ZP, Welkoborsky HJ, et al.: Prognostic indicators for squamous cell carcinoma of the oral cavity: a clinicopathologic correlation? Laryngoscope 1997, 107:1239–1244.

    Article  PubMed  CAS  Google Scholar 

  49. Hicks WL Jr, Loree TR, Garcia RI, et al.: Squamous cell carcinoma of the floor of mouth: a 20-year review? Head Neck 1997, 19:400–405. One of the largest reviews of patients with floor-of-mouth cancer, with an emphasis on surgical treatment results and locoregional control rates.

    Article  PubMed  Google Scholar 

  50. Cooley ML, Hoffman HT, Robinson RA: Discrepancies in frozen section mucosal margin tissue in laryngeal squamous cell carcinoma? Head Neck 2002, 24:262–267.

    Article  PubMed  Google Scholar 

  51. Johnson RE, Sigman JD, Funk GF, et al.: Quantification of surgical margin shrinkage in the oral cavity? Head Neck 1997, 19:281–286.

    Article  PubMed  CAS  Google Scholar 

  52. Smeele LE, Leemans CR, Langendijk JA, et al.: Positive surgical margins in neck dissection specimens in patients with head and neck squamous cell carcinoma and the effect of radiotherapy? Head Neck 2000, 22:559–563.

    Article  PubMed  CAS  Google Scholar 

  53. Hiratsuka H, Miyakawa A, Nakamori K, et al.: Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity? Cancer 1997, 80:351–356.

    Article  PubMed  CAS  Google Scholar 

  54. Looser KG, Shah JP, Strong EW: The significance of “positive” margins in surgically resected epidermoid carcinomas? Head Neck Surg 1978, 1:107–111.

    Article  PubMed  CAS  Google Scholar 

  55. Parsons JT, Mendenhall WM, Stringer SP, et al.: An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity? Int J Radiat Oncol Biol Phys 1997, 39:137–148. Consideration of indications and approach to radiation therapy in the postoperative setting often includes criteria, which have been better defined by this study.

    Article  PubMed  CAS  Google Scholar 

  56. Spiro RH, Huvos AG, Wong GY, et al.: Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth? Am J Surg 1986, 152:345–350.

    Article  PubMed  CAS  Google Scholar 

  57. Ord RA, Aisner S: Accuracy of frozen sections in assessing margins in oral cancer resection? J Oral Maxillofac Surg 1997, 55:663–669.

    Article  PubMed  CAS  Google Scholar 

  58. Loree TR, Strong EW: Significance of positive margins in oral cavity squamous carcinoma? Am J Surg 1990, 160:410–414.

    Article  PubMed  CAS  Google Scholar 

  59. Partridge M, Li SR, Pateromichelakis S, et al.: Detection of minimal residual cancer to investigate why oral tumors recur despite seemingly adequate treatment? Clin Cancer Res 2000, 6:2718–2725.

    PubMed  CAS  Google Scholar 

  60. Mazeron JJ, Grimard L, Raynal M, et al.: Iridium-192 curietherapy for T1 and T2 epidermoid carcinomas of the floor of mouth? Int J Radiat Oncol Biol Phys 1990, 18:1299–1306.

    PubMed  CAS  Google Scholar 

  61. Cole D, Patel P, Matar J: Floor of mouth cancer? Arch Otolaryngol Head Neck Surg 1994, 120:260–263.

    PubMed  CAS  Google Scholar 

  62. Spiro RH, Strong EW: Epidermoid carcinoma of the mobile tongue: treatment by partial glossectomy alone? Am J Surg 1971, 122:707–710.

    Article  PubMed  CAS  Google Scholar 

  63. O’Brien CJ, Lahr CJ, Soong SJ, et al.: Surgical treatment of early-stage carcinoma of the oral tongue-would adjuvant treatment be beneficial? Head Neck Surg 1986, 8:401–408.

    Article  PubMed  CAS  Google Scholar 

  64. Zelefsky MJ, Harrison LB, Fass DE, et al.: Postoperative radiotherapy for oral cavity cancers: impact of anatomic subsite on treatment outcome? Head Neck 1990, 12:470–475.

    Article  PubMed  CAS  Google Scholar 

  65. Lindberg R: Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts? Cancer 1972, 29:1446–1449. A classic description of the lymphatic spread of head and neck cancer.

    Article  PubMed  CAS  Google Scholar 

  66. Shah JP: Cervical lymph node metastases: diagnostic, therapeutic, and prognostic implications? Oncology (Huntingt) 1990, 4:61–69.

    CAS  Google Scholar 

  67. Kowalski LP: Results of salvage treatment of the neck in patients with oral cancer? Arch Otolaryngol Head Neck Surg 2002, 128:58–62.

    PubMed  Google Scholar 

  68. Hughes CJ, Gallo O, Spiro RH, Shah JP: Management of occult neck metastases in oral cavity squamous carcinoma? Am J Surg 1993, 166:380–383. A study showing that the level of lymph node metastases is an important prognostic indicator in patients with oral cancer.

    Article  PubMed  CAS  Google Scholar 

  69. Kowalski LP, Bagietto R, Lara JR, et al.: Prognostic significance of the distribution of neck node metastasis from oral carcinoma? Head Neck 2000, 22:207–214.

    Article  PubMed  CAS  Google Scholar 

  70. Spiro JD, Spiro RH, Shah JP, et al.: Critical assessment of supraomohyoid neck dissection? Am J Surg 1988, 156:286–289.

    Article  PubMed  CAS  Google Scholar 

  71. Byers RM, Weber RS, Andrews T, et al.: Frequency and therapeutic implications of “skip metastases” in the neck from squamous carcinoma of the oral tongue? Head Neck 1997, 19:14–19. The results of this report should be considered in the evaluation and management of patients diagnosed with tongue cancer.

    Article  PubMed  CAS  Google Scholar 

  72. O’Brien CJ, Traynor SJ, McNeil E, et al.: The use of clinical criteria alone in the management of the clinically negative neck among patients with squamous cell carcinoma of the oral cavity and oropharynx? Arch Otolaryngol Head Neck Surg 2000, 126:360–365.

    PubMed  CAS  Google Scholar 

  73. Clayman GL, Frank DK: Selective neck dissection of anatomically appropriate levels is as efficacious as modified radical neck dissection for elective treatment of the clinically negative neck in patients with squamous cell carcinoma of the upper respiratory and digestive tracts? Arch Otolaryngol Head Neck Surg 1998, 124:348–352. This article provides additional evidence of the use of selective neck dissection as an alternative to more comprehensive procedures in the management of head and neck cancer.

    PubMed  CAS  Google Scholar 

  74. Ambrosch P, Freudenberg L, Kron M, Steiner W: Selective neck dissection in the management of squamous cell carcinoma of the upper digestive tract? Eur Arch Otorhinolaryngol 1996, 253:329–335.

    Article  PubMed  CAS  Google Scholar 

  75. Woolgar JA: Histological distribution of cervical lymph node metastases from intraoral/oropharyngeal squamous cell carcinomas? Br J Oral Maxillofac Surg 1999, 37:175–180.

    Article  PubMed  CAS  Google Scholar 

  76. Koch WM, Choti MA, Civelek AC, et al.: Gamma probedirected biopsy of the sentinel node in oral squamous cell carcinoma? Arch Otolaryngol Head Neck Surg 1998, 124:455–459.

    PubMed  CAS  Google Scholar 

  77. Wendt CD, Peters LJ, Delclos L, et al.: Primary radiotherapy in the treatment of stage I and II oral tongue cancers: importance of the proportion of therapy delivered with interstitial therapy? Int J Radiat Oncol Biol Phys 1990, 18:1287–1292.

    PubMed  CAS  Google Scholar 

  78. Fu KK, Pajak TF, Trotti A, et al.: Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003? Int J Radiat Oncol Biol Phys 2000, 48:7–16. An in-depth look at the various radiation techniques and early results in patients with head and neck cancers.

    Article  PubMed  CAS  Google Scholar 

  79. Ang KK: Altered fractionation trials in head and neck cancer? Semin Radiat Oncol 1998, 8:230–236.

    Article  PubMed  CAS  Google Scholar 

  80. Adelstein DJ, Saxton JP, Lavertu P, et al.: Maximizing local control and organ preservation in stage IV squamous cell head and neck cancer with hyperfractionated radiation and concurrent chemotherapy? J Clin Oncol 2001, 20:1405–1410.

    Article  Google Scholar 

  81. Calais G, Alfonsi M, Bardet E, et al.: Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma? J Natl Cancer Inst 1999, 91:2081–2086. This study provides convincing data in support of the use of concomitant chemotherapy and radiation therapy in patients with oropharyngeal cancer.

    Article  PubMed  CAS  Google Scholar 

  82. Forastiere AA, Trotti A: Radiotherapy and concurrent chemotherapy: a strategy that improves locoregional control and survival in oropharyngeal cancer? J Natl Cancer Inst 1999, 91:2065–2066.

    Article  PubMed  CAS  Google Scholar 

  83. Beitler JJ, Smith RV, Silver CE, et al.: Close or positive margins after surgical resection for the head and neck cancer patient: the addition of brachytherapy improves local control? Int J Radiat Oncol Biol Phys 1998, 40:313–317.

    Article  PubMed  CAS  Google Scholar 

  84. Chao KS, Majhail N, Huang CJ, et al.: Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques? Radiother Oncol 2001, 61:275–280. With an emerging trend toward salivary protection and toxicity reduction, IMRT may provide benefit without a decrease in locoregional control.

    Article  PubMed  CAS  Google Scholar 

  85. Brizel DM, Wasserman TH, Henke M, et al.: Phase III randomized trial of amifostine as a radioprotector in head and neck cancer? J Clin Oncol 2000, 18:3339–3345. Toxicity reduction in head and neck radiation often includes xerostomia, which is significantly reduced through intravenous use of amifostine in this study.

    PubMed  CAS  Google Scholar 

  86. Horiot JC, Lipinski F, Schraub S, et al.: Post-radiation severe xerostomia relieved by pilocarpine: a prospective French cooperative study? Radiother Oncol 2000, 55:233–239.

    Article  PubMed  CAS  Google Scholar 

  87. Petrovich Z, Parker RG, Luxton G, et al.: Carcinoma of the lip and selected sites of head and neck skin: a clinical study of 896 patients? Radiother Oncol 1987, 8:11–17.

    Article  PubMed  CAS  Google Scholar 

  88. Mazeron JJ, Crook JM, Benck V, et al.: Iridium 192 implantation of T1 and T2 carcinomas of the mobile tongue? Int J Radiat Oncol Biol Phys 1990, 19:1369–1376.

    PubMed  CAS  Google Scholar 

  89. Mazeron JJ, Crook JM, Marinello G, et al.: Prognostic factors of local outcome for T1, T2 carcinomas of oral tongue treated by iridium 192 implantation? Int J Radiat Oncol Biol Phys 1990, 19:281–285.

    PubMed  CAS  Google Scholar 

  90. Laramore GE, Scott CB, al-Sarraf M, et al.: Adjuvant chemotherapy for resectable squamous cell carcinoma of the head and neck: report on Intergroup Study 0034? Int J Radiat Oncol Biol Phys 1992, 23:705–713.

    PubMed  CAS  Google Scholar 

  91. Cooper JS, Pajak TF, Forastiere A, et al.: Precisely defining high-risk operable head and neck tumors based on RTOG #85-03 and #88-24: targets for postoperative radiochemotherapy? Head Neck 1998, 20:588–594. This paper presents evidence-based prognostic factors for recurrence after head and neck cancer surgery that may serve as criteria for trials of adjuvant therapy.

    Article  PubMed  CAS  Google Scholar 

  92. Bourhis J, Calais G, Eschwege F: Chemoradiotherapy of carcinomas of the upper aerodigestive tract? Cancer Radiother 1998, 2:679–688.

    PubMed  CAS  Google Scholar 

  93. Lefebvre JL, Chevalier D, Luboinski B, et al.: Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group? J Natl Cancer Inst 1996, 88:890–899.

    Article  PubMed  CAS  Google Scholar 

  94. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Verterans Affairs Laryngeal Cancer Study Group. N Engl J Med 1991, 324:1685–1690.

  95. Brizel DM, Albers ME, Fisher SR, et al.: Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer? N Engl J Med 1998, 338:1798–1804.

    Article  PubMed  CAS  Google Scholar 

  96. Vokes EE, Kies MS, Haraf DJ, et al.: Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer? J Clin Oncol 2000, 18:1652–1661. This study examines the treatment results and potential for adjuvant surgical treatment in patients treated primarily with concomitant chemotherapy and radiation therapy.

    PubMed  CAS  Google Scholar 

  97. Adelstein DJ, Lavertu P, Saxton JP, et al.: Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck? Cancer 2000, 88:876–883. Additional evidence of the use of concurrent chemotherapy and radiation therapy in patients with advanced head and neck cancers from a large multi-institutional trial.

    Article  PubMed  CAS  Google Scholar 

  98. Lamont EB, Vokes EE: Chemotherapy in the management of squamous-cell carcinoma of the head and neck? Lancet Oncol 2001, 2:261–269.

    Article  PubMed  CAS  Google Scholar 

  99. Forastiere AA: Chemotherapy of head and neck cancer? Ann Oncol 1992, 3(Suppl 3):11–14.

    PubMed  Google Scholar 

  100. Khuri FR, Nemunaitis J, Ganly I, et al.: A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer? Nat Med 2000, 6:879–885.

    Article  PubMed  CAS  Google Scholar 

  101. Beumer J III, Marunick M, Roumanos E, et al.: Restoration of facial defects: etiology, disability, and rehabilitation. In Maxillofacial Rehabilitation: Prosthodontic and Surgical Considerations, CT. Edited by Beumer J III, Curtis TA, Marunick M. St. Louis: Ishijaku Euro America; 1996:337–453.

    Google Scholar 

  102. Marunick MT, Mathes BE, Klein BB: Masticatory function in hemimandibulectomy patients? J Oral Rehabil 1992, 19:289–295.

    Article  PubMed  CAS  Google Scholar 

  103. Urken ML, Buchbinder D, Weinberg H, et al.: Functional evaluation following microvascular oromandibular reconstruction of the oral cancer patient: a comparative study of reconstructed and nonreconstructed patients? Laryngoscope 1991, 101:935–950.

    PubMed  CAS  Google Scholar 

  104. Lazarus CL, Logemann JA, Pauloski BR, et al.: Swallowing and tongue function following treatment for oral and oropharyngeal cancer? J Speech Lang Hear Res 2000, 43:1011–1023.

    PubMed  CAS  Google Scholar 

  105. Hamlet S, Jones L, Mathog R, et al.: Bolus propulsive activity of the tongue in dysphagic cancer patients? Dysphagia 1988, 3:18–23.

    Article  PubMed  CAS  Google Scholar 

  106. Logemann JA, Pauloski BR, Rademaker AW, et al.: Speech and swallow function after tonsil/base of tongue resection with primary closure? J Speech Hear Res 1993, 36:918–926.

    PubMed  CAS  Google Scholar 

  107. Pauloski BR, Logemann JA, Rademaker AW, et al.: Speech and swallowing function after anterior tongue and floor of mouth resection with distal flap reconstruction? J Speech Hear Res 1993, 36:267–276.

    PubMed  CAS  Google Scholar 

  108. Pauloski BR, Logemann JA, Rademaker AW, et al.: Speech and swallowing function after oral and oropharyngeal resections: one-year follow-up? Head Neck 1994, 16:313–322.

    Article  PubMed  CAS  Google Scholar 

  109. Hirsch SM, Caldarelli DD, Hutchinson JC Jr, et al.: Concomitant chemotherapy and split-course radiation for cure and preservation of speech and swallowing in head and neck cancer? Laryngoscope 1991, 101:583–586.

    Article  PubMed  CAS  Google Scholar 

  110. Martin BJ, Logemann JA, Shaker R, Dodds WJ: Coordination between respiration and swallowing: respiratory phase relationships and temporal integration? J Appl Physiol 1994, 76:714–723.

    PubMed  CAS  Google Scholar 

  111. Zitsch RP 3rd, Todd DW, Renner GJ, Singh A: Intraoperative radiolymphoscintigraphy for detection of occult nodal metastasis in patients with head and neck squamous cell carcinoma? Otolaryngol Head Neck Surg 2000, 122:662–666. Although commonly used in melanoma, few studies have evaluated the application of sentinel lymph node biopsy in SCC. This report provides early results and insight into its use in head and neck cancer.

    Article  PubMed  Google Scholar 

  112. Vokes EE, Haraf DJ, Brockstein BE, Weichselbaum RR: Paclitaxel, 5-fluorouracil, hydroxyurea, and concomitant radiation therapy for poor-prognosis head and neck cancer? Semin Radiat Oncol 1999, 9:70–76.

    PubMed  CAS  Google Scholar 

  113. Clayman GL, el-Naggar AK, Lippman SM, et al.: Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinomas? J Clin Oncol 1998, 16:2221–2232.

    PubMed  CAS  Google Scholar 

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Day, T.A., Davis, B.K., Gillespie, M.B. et al. Oral cancer treatment. Curr. Treat. Options in Oncol. 4, 27–41 (2003). https://doi.org/10.1007/s11864-003-0029-4

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  • DOI: https://doi.org/10.1007/s11864-003-0029-4

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