Opinion statement
Carcinoma of the vagina is an uncommon gynecologic cancer in the United States and throughout the world. Carcinoma in situ of the vagina and very early stage invasive carcinoma of the vagina may be treated with surgery. However, the standard therapeutic intervention for patients with carcinoma of the vagina is radiation therapy. In early stage vaginal carcinoma, radiation therapy is chosen for definitive treatment to preserve the anatomy and function of the vagina. In more advanced stages of vaginal carcinoma, radiation therapy is chosen as the standard treatment to avoid exenterative surgery, preserve anatomy and function, and to treat known or presumed lymph node metastasis. No randomized studies comparing irradiation alone versus irradiation and chemotherapy have been performed for patients with advanced carcinoma of the vagina. The standard therapy for patients with advanced cervical carcinoma is irradiation and concurrent cisplatin-based chemotherapy. Because the etiology and epidemiology of vaginal carcinoma appears identical to those of patients with invasive cervical carcinoma, patients with advanced vaginal carcinoma should be treated with irradiation and concurrent cisplatin-based chemotherapy.
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References and Recommended Reading
Creasman WT, Phillips JL, Menck HR: The national cancer data base report on cancer of the vagina. Cancer 1998, 83:1033–1040.
Beller U, Sideri M, Maisonneuve P, et al.: Carcinoma of the vagina. J Epidemiol Biostat 2001, 6:141–152.
Grigsby PW, Siegel BA, Dehdashti F: Lymph node staging by positron emission tomography in patients with carcinoma of the cervix. J Clin Oncol 2001, 19:3745–3749.
Curtis P, Shepherd JH, Lowe DG, et al.: The role of partial colpectomy in the management of persistent vaginal neoplasia after primary treatment. Br J Obstet Gynaecol 1992, 99:587–589.
Stock RG, Chen ASJ, Seski J: A 30-year experience in the management of primary carcinoma of the vagina: analysis of prognostic factors and treatment modalities. Gynecol Oncol 1995, 56:45–52.
Look KY: Organ sparing management for carcinoma of the vulva and vagina. Eur J Gynaecol Oncol 2000, 21:439–446.
Kirkbride P, Fyles A, Rawlings GA, et al.: Carcinoma of the vagina: experience at the Princess Margaret Hospital. Gynecol Oncol 1995, 56:435–443.
Perez CA, Grigsby PW, Garipagaoglu M, et al.: Factors affecting long-term outcome of irradiation in carcinoma of the vagina. Int J Radiat Oncol Biol Phys 1999, 44:37–45.
Chyle V, Zagars GK, Wheeler JA, et al.: Definitive radiotherapy for carcinoma of the vagina: outcome and prognostic factors. Int J Radiat Oncol Biol Phys 1996, 35:891–905.
Pingley S, Shrivastava SK, Sarin R, et al.: Primary carcinoma of the vagina: Tata Memorial Hospital experience. Int J Radiat Oncol Biol Phys 2000, 46:101–108.
Stock RG, Mychalczak B, Armstrong JG, et al.: The importance of brachytherapy technique in the management of primary carcinoma of the vagina. Int J Radiat Oncol Biol Phys 1992, 24:747–753.
Leung S, Sexton M: Radical radiation therapy for carcinoma of the vagina: impact of treatment modalities on outcome: Peter MacCallum Cancer Institute experience 1970-1990. Int J Radiat Oncol Biol Phys 1992, 25:413–418.
Tewari KS, Cappuccini F, Puthawala AA, et al.: Primary invasive carcinoma of the vagina: treatment with interstitial brachytherapy. Cancer 2001, 91:758–770.
Nanavati PJ, Fanning J, Hilgers RD, et al.: High-doserate brachytherapy in primary stage I and II vaginal cancer. Gynecol Oncol 1993, 51:67–71.
Thigpen JT, Blessing JA, Homesley HD, et al.: Phase II trial of cisplatin in advanced or recurrent cancer of the vagina: a Gynecologic Oncology Group study. Gynecol Oncol 1986, 23:101–104.
Zanetta G, Lissoni A, Gabriele A, et al.: Intense neoadjuvant chemotherapy with cisplatin and epirubicin for advanced or bulky cervical and vaginal adenocarcinoma. Gynecol Oncol 1997, 64:431–435.
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Grigsby, P.W. Vaginal cancer. Curr. Treat. Options in Oncol. 3, 125–130 (2002). https://doi.org/10.1007/s11864-002-0058-4
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DOI: https://doi.org/10.1007/s11864-002-0058-4