Skip to main content

Advertisement

SpringerLink
Log in

Nonfunctioning islet cell carcinoma of the pancreas

  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

Opinion statement

Islet cell cancers of the pancreas may follow an indolent course. Unlike adenocarcinoma of the pancreas, which is considered inoperable for cure in the presence of metastatic disease, islet cell carcinoma of the pancreas in selected cases warrants an aggressive approach toward resection. Significant palliation may be obtained from resection of primary tumors despite the presence of liver metastases. Furthermore, resection or ablation of limited, metastatic disease in the liver may be indicated. Therapeutic decisions must consider the patient’s symptoms, coexisting morbidities, and the extent of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Solorzano CC, Lee JE, Pisters PW, et al.: Nonfunctioning islet cell carcinoma of the pancreas: survival results in a contemporary series of 163 patients. Surgery 2001, 130:1078–1085.

    Article  PubMed  CAS  Google Scholar 

  2. Miller AR, Sarr MF, Van Heerden JA: Cystic and nonfunctioning islet cell tumors. In Surgical Diseases of the Pancreas, edn 3. Edited by Howard J. Baltimore: Williams & Wilkins; 1998:777–787.

    Google Scholar 

  3. Merrell RC, Evans DB: Pancreatic polypeptideproducing and nonfunctioning islet cell tumors of the pancreas. In The Pancreas, edn 1. Edited by Beger HG, Warshaw AL, Bücher M, et al. Oxford, UK: Blackwell Science; 1998, 2:1275–1283.

    Google Scholar 

  4. Bartsch DK, Schilling T, Ramaswamy A, et al.:Management of nonfunctioning islet cell carcinomas. World J Surg 2000, 24:1418–1424.

    Article  PubMed  CAS  Google Scholar 

  5. Physicians Desk Reference, edn 56. Montvale, NJ: Medical Economics Company; 2002:2394-2399.

  6. Bartolomeo M, Bajetta E, Buzzoni R, et al.: Clinical efficacy of octreotide in the treatment of metastatic neuroendocrine tumors. Presented at the 19th Congress of the European Society for Medical Oncology, Lisbon, Portugal, November 18–22, 1994.

  7. Moertel CG, Lefkopoulo M, Lipsitz S, et al.: Streptozocindoxorubicin, streptozocin-fluorouracil, or chlorozotocin in the treatment of advanced islet-cell carcinoma. N Engl J Med 1992, 326:519–523.

    Article  PubMed  CAS  Google Scholar 

  8. Van Eijck CH, Lamberts SW, Luciene CJ, et al.: The use of somatostatin receptor scintigraphy in the differential diagnosis of pancreatic duct cancers and islet cell tumors. Ann Surg 1996, 224:119–124.

    Article  Google Scholar 

  9. Tennvall J, Ljungberg O, Ahren B, et al.: Radiotherapy for unresectable endocrine pancreatic carcinomas. Eur Surg Oncol 1992, 18:73–76.

    CAS  Google Scholar 

  10. Torrisi JR, Treat J, Zeman R, et al.: Radiotherapy in the management of pancreatic cell tumors. Cancer 1987, 60:1226–1231.

    Article  PubMed  CAS  Google Scholar 

  11. Sarmiento J, Florencia G, Grant C, et al.: Concurrent resections of pancreatic islet cell cancers with synchronous hepatic metastases: outcomes of an aggressive approach. Surgery; In press.

  12. Chamberlain RS, Canes D, Brown KT, et al.: Hepatic neuroendocrine metastases: does intervention alter outcomes. J Am Coll Surg 2000, 190:432–445.

    Article  PubMed  CAS  Google Scholar 

  13. Yao KA, Talamonti MS, Nemcek A, et al.: Indications and results of liver resection and hepatic chemoembolization for metastatic gastrointestinal neuroendocrine tumors. Surgery 2001, 130:677–682.

    Article  PubMed  CAS  Google Scholar 

  14. Le Treut YP, Delpero JR, Dousset B, et al.: Results of liver transplantation in the treatment of metastatic neuroendocrine tumors: a 31-case French multicentric report. Ann Surg 1997, 225:355–364.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Arizona Medical Center, 1501 N. Campbell Avenue, 85724, Tucson, AZ, USA

    Steven Neeleman MD & Michael J. Demeure MD

Authors
  1. Steven Neeleman MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael J. Demeure MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Neeleman, S., Demeure, M.J. Nonfunctioning islet cell carcinoma of the pancreas. Curr. Treat. Options in Oncol. 3, 355–360 (2002). https://doi.org/10.1007/s11864-002-0035-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11864-002-0035-y

Keywords

Search

Navigation