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Gestational Trophoblastic Disease

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Patients diagnosed with molar pregnancy are treated by either suction curettage or hysterectomy, depending on their desire to preserve fertility. We use single-agent chemotherapy, preferably methotrexate, to treat low- or moderate-risk persistent trophoblastic tumors. High-risk patients who have metastatic disease are treated primarily with combination chemotherapy and, as indicated, adjuvant radiotherapy or surgery. We perform a hysterectomy in all cases of placental-site trophoblastic tumors; combination chemotherapy is used if there is evidence of metastatic disease.

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References and Recommended Reading

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Authors and Affiliations

  1. Division of Gynecologic Oncology, Brigham and Women’s Hospital, 75 Francis Street, 02115, Boston, MA, USA

    John O. Schorge MD, Donald P. Goldstein MD, Marilyn R. Bernstein MHP & Ross S. Berkowitz MD

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  1. John O. Schorge MD
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  2. Donald P. Goldstein MD
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  3. Marilyn R. Bernstein MHP
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  4. Ross S. Berkowitz MD
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Schorge, J.O., Goldstein, D.P., Bernstein, M.R. et al. Gestational Trophoblastic Disease. Curr. Treat. Options in Oncol. 1, 169–175 (2000). https://doi.org/10.1007/s11864-000-0062-5

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  • DOI: https://doi.org/10.1007/s11864-000-0062-5

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