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Fibrous tumors of the pleura

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Opinion statement

Fibrous tumor of the pleura is a rare tumor arising from mesenchymal cells underlying the visceral or parietal pleura. The tumor may have benign or malignant histological features, but these do not always predict the clinical behavior of the tumor. In most cases, the tumor appears pedunculated, and simple resection of the tumor is curative even if significant cellular atypia is present. In contrast, some tumors with a broad base of attachment may recur and occasionally become malignant. Complete surgical resection is the mainstay of therapy for both benign and malignant fibrous tumors of the pleura. When resection is incomplete or impossible, external radiation therapy with or without chemotherapy is recommended.

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References and Recommended Reading

  1. Klemperer P, Rabin CB: Primary neoplasms of the pleura. Arch Pathol 1931, 11:385–412.

    Google Scholar 

  2. Said JW, Nash G, Banks-Schlegel S, et al.: Localized fibrous mesothelioma: an immunohistochemical and electron microscopic study. Hum Pathol 1984, 15:440–443.

    Article  PubMed  CAS  Google Scholar 

  3. van de Rijn M, Lombard CM, Rouse RV: Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum, and lung. Am J Surg Pathol 1994, 18:814–820.

    Article  PubMed  Google Scholar 

  4. Chan JKC: Solitary fibrous tumour—everywhere, and a diagnosis in vogue. Histopathology 1997, 31:568–576. The author presents a review of the histopathologic characteristics of solitary fibrous tumors.

    Article  PubMed  CAS  Google Scholar 

  5. England DM, Hochholzer L, McCarthy MJ: Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol 1989, 13:640–658. This study is the largest reported in the literature. The authors present the main characteristics of fibrous tumor of the pleura and report histologic features permitting to differentiate benign from malignant variants.

    Article  PubMed  CAS  Google Scholar 

  6. Briselli M, Mark EJ, Dickersin GR: Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature. Cancer 1981, 47:2678–2689.

    Article  PubMed  CAS  Google Scholar 

  7. de Perrot M, Kurt AM, Robert JH, et al.: Clinical behavior of solitary fibrous tumors of the pleura. Ann Thorac Surg 1999, 67:1456–1459.

    Article  PubMed  Google Scholar 

  8. Robinson LA, Reilly RB: Localized pleural mesothelioma. The clinical spectrum. Chest 1994, 106:1611–1615.

    PubMed  CAS  Google Scholar 

  9. Ferretti GR, Chiles C, Cox JE, et al.: Localized benign fibrous tumors of the pleura: MR appearance. J Comput Assist Tomogr 1997, 21:115–120.

    Article  PubMed  CAS  Google Scholar 

  10. Okike N, Bernatz PE, Woolner LB: Localized mesothelioma of the pleura. Benign and malignant variants. J Thorac Cardiovasc Surg 1978, 75:363–372.

    PubMed  CAS  Google Scholar 

  11. Yousem SA, Flynn SD: Intrapulmonary localized fibrous tumor. Intraparenchymal so-called localized fibrous mesothelioma. Am J Clin Pathol 1988, 89:365–369.

    PubMed  CAS  Google Scholar 

  12. Saifuddin A, Da Costa P, Chalmers AG, et al.: Primary malignant localized fibrous tumours of the pleura: clinical, radiological and pathological features. Clin Radiol 1992, 45:13–17.

    Article  PubMed  CAS  Google Scholar 

  13. Aufiero TX, McGary SA, Campbell DB, Phillips PP: Intrapulmonary benign fibrous tumor of the pleura. J Thorac Cardiovasc Surg 1995, 110:549–551.

    Article  PubMed  CAS  Google Scholar 

  14. Witkin GB, Rosai J: Solitary fibrous tumor of the mediastinum. A report of 14 cases. Am J Surg Pathol 1989, 13:547–557.

    Article  PubMed  CAS  Google Scholar 

  15. Martini N, McCormack PM, Bains MS, et al.: Pleural mesothelioma. Ann Thorac Surg 1987, 43:113–120.

    Article  PubMed  CAS  Google Scholar 

  16. Armand JP, Seymour L, Evans TR: Raltitrexed (Tomudex) in combination with platinum-based agents and/or anthracyclines: preliminary results of phase I clinical trials. Eur J Cancer 1999, 35:S14-S18.

    Article  PubMed  CAS  Google Scholar 

  17. Thodtmann R, Depenbrock H, Dumez H, et al.: Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin. J Clin Oncol 1999, 17:3009–3016.

    PubMed  CAS  Google Scholar 

  18. Pass HI: Photodynamic therapy and thoracic malignancies. In Advanced Therapy in Thoracic Surgery. Edited by Franco KL, Putnam JB. Hamilton, Canada: BC Decker; 1998:127–138.

    Google Scholar 

  19. Baas P, Murrer L, Zoetmulder FA, et al.: Photodynamic therapy as adjuvant therapy in surgically treated pleural malignancies. Br J Cancer 1997, 76:819–826.

    PubMed  CAS  Google Scholar 

  20. Dal Cin P, Pauwels P, Van den Berghe H: Solitary fibrous tumour of the pleura with t(4;15) (q13;q26). Histopathology 1999, 35:94–95.

    Article  Google Scholar 

  21. Suster S, Fisher C, Moran CA: Expression of bcl-2 oncoprotein in benign and malignant spindle cell tumors of soft tissue, skin, serosal surfaces, and gastrointestinal tract. Am J Surg Pathol 1998, 22:863–872.

    Article  PubMed  CAS  Google Scholar 

  22. Hasegawa T, Matsuno Y, Shimoda T, et al.: Frequent expression of bcl-2 protein in solitary fibrous tumors. Jpn J Clin Oncol 1998, 28:86–91.

    Article  PubMed  CAS  Google Scholar 

  23. Pass HI, Robinson BW, Testa JR, Carbone M: Emerging translational therapies for mesothelioma. Chest 1999, 116:455S-460S.

    Article  PubMed  CAS  Google Scholar 

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de Perrot, M. Fibrous tumors of the pleura. Curr. Treat. Options in Oncol. 1, 293–298 (2000). https://doi.org/10.1007/s11864-000-0044-7

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  • DOI: https://doi.org/10.1007/s11864-000-0044-7

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