Wuhan University Journal of Natural Sciences

, Volume 20, Issue 5, pp 413–420 | Cite as

Histopathology and ultrastructural pathology of cyprinid herpesvirus II (CyHV-2) infection in gibel carp, Carassius auratus gibelio

  • Nan Jiang
  • Jin Xu
  • Jie Ma
  • Yuding Fan
  • Yong Zhou
  • Wenzhi Liu
  • Lingbing Zeng
Biology and Enviromental Science


Cyprinid herpesvirus II (CyHV-2) infection is identified in cultured gibel carp, Carassius auratus gibelio, with high mortality in China in recent years. Histological pathology includes acute hepatocellular necrosis, splenic necrosis, kidney necrosis, hyperplasia of the secondary lamellae with focal necrosis. Acute necrotic myocarditis and granulocytes are prominent within the cardiac lumen in infected fish. In addition, necrosis is observed in the submucosa and mucosa epithelium of intestinal tract. Edemas are observed in renal glomerulus, submucosa and mucosa epithelium of intestinal tract, myocardial cells and neurons. Transmission electron microscopy indicates the cytoplasmic inclusions in splenocytes, glomerulus cells and hematopoietic tissue cells of kidney, epithelial cells of gills and brain cells. The histopathology and ultrastructural pathology in CyHV-2 infected gibel carp are characterized with extensive necrosis and cytoplasmic inclusions in spleen, kidney, gill and brain, which suggests that CyHV-2 may mainly infect the spleen, kidney, gill and brain of fish.


Cyprinid herpesvirus II gibel carp histopathology ultrastructural pathology necrosis 

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Copyright information

© Wuhan University and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Nan Jiang
    • 1
    • 2
  • Jin Xu
    • 1
  • Jie Ma
    • 1
  • Yuding Fan
    • 1
  • Yong Zhou
    • 1
  • Wenzhi Liu
    • 1
  • Lingbing Zeng
    • 1
  1. 1.Division of Fish Disease, Yangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan, HubeiChina
  2. 2.College of FisheriesHuazhong Agricultural UniversityWuhan, HubeiChina

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