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Multifunctions of histone H1 proteins

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Wuhan University Journal of Natural Sciences

Abstract

Among various histones, histone H1 proteins have been appreciated for their multiple functions in diverse biological processes. In addition to being a structural protein in chromatin, H1 proteins also play critical roles in cell cycle, gene expression, and development. Recent studies reveal the possible effects of H1 in some diseases, such as cancer and neurodegenerative diseases. Here, we review different variants of H1, the functions, and post translational modifications of H1 variants are also discussed.

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Authors and Affiliations

  1. College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, China

    Wenjun Wang, Ruiqi Cai, Hongdou Xiao & Ling Zheng

  2. Diabetes Center, Wuhan University, Wuhan, 430072, Hubei, China

    Wenjun Wang, Ruiqi Cai, Hongdou Xiao & Ling Zheng

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  1. Wenjun Wang
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  2. Ruiqi Cai
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  4. Ling Zheng
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Correspondence to Ling Zheng.

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Foundation item: Supported by the National Basic Research Program of China (2012CB524901), the Natural Science Foundation of China (31271370, 81100687), and the Program for New Century Excellent Talents in University (NECT10-0623)

Biography: WANG Wenjun, female, Ph.D. candidate, research direction: diabetes and its complications.

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Wang, W., Cai, R., Xiao, H. et al. Multifunctions of histone H1 proteins. Wuhan Univ. J. Nat. Sci. 19, 8–18 (2014). https://doi.org/10.1007/s11859-014-0972-x

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