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A new biselector chiral stationary phase derived from tartaric acid and its enantioseparation evaluation

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Wuhan University Journal of Natural Sciences

Abstract

Two chiral selectors were synthesized from tartaric acid. The selectors were simultaneously immobilized on 3-aminopropyl silica gel to obtain a new biselector chiral stationary phase (CSP) in order to determine the influence of selector structure of biselector CSPs on the chiral recognition capability. For comparison, the single-selector CSP was also prepared. The biselector CSP shows an improved overall chiral recognition capability in comparison with the single-selector CSP. During the enantioseparation, temporary diastereoisomers are likely formed by complexation between a chiral analyte and the two selectors on the biselector CSP. The functional groups in the two selectors are complementary in electronic effect and/or in steric hindrance for the chiral recognition.

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Authors and Affiliations

  1. Key Laboratory of Green Chemical Process of Ministry of Education/Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology/Wuhan Institute of Technology, Wuhan, 430073, Hubei, China

    Wei Chen, Juan Zhang, Yingzhao Li & Zhengwu Bai

  2. Key Laboratory of Biodiesel of the Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, Shandong, China

    Shaohua Huang

Authors
  1. Wei Chen
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  2. Juan Zhang
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  3. Yingzhao Li
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  4. Zhengwu Bai
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  5. Shaohua Huang
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Correspondence to Zhengwu Bai.

Additional information

Foundation item: Supported by the National Natural Science Foundation of China (20675061 and 50973086) and the Research Project of Department of Education of Hubei Province (Z20081501)

Biography: CHEN Wei, male, Lecturer, research direction: chiral separation materials.

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Chen, W., Zhang, J., Li, Y. et al. A new biselector chiral stationary phase derived from tartaric acid and its enantioseparation evaluation. Wuhan Univ. J. Nat. Sci. 17, 383–390 (2012). https://doi.org/10.1007/s11859-012-0859-7

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  • DOI: https://doi.org/10.1007/s11859-012-0859-7

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