Abstract
A highly sensitive and simple Rayleigh light scattering (RLS) method for determination of ciprofloxacin hydrochloride has been developed. Ciprofloxacin hydrochloride (CPFH) reacted with tetraphenylboron sodium(TPB) to form an ion-association complex in pH 5.31 aqueous solution, which resulted in a significant enhancement of the RLS intensity, which was linear with the concentration of CPFH in the range of 12.7–419 ng·mL−1. The limit of detection for CPFH was 6.99 ng·mL−1. The method is simple, highly sensitive and selective within a wide linear range. Appliying this method to determination of ciprofloxacin hydrochloride in pharmaceutical preparations and biological fluids obtained satisfactory results.
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Foundation item: Supported by the National Natural Science Foundation of China(20675059) and Research Foundation of Leshan Teachers’ College, China (Z0625)
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Li, X., Cao, Q. & Wang, F. Determination of ciprofloxacin hydrochloride in pharmaceutical preparation and biological fluid by Rayleigh light scattering technique. Wuhan Univ. J. Nat. Sci. 14, 70–74 (2009). https://doi.org/10.1007/s11859-009-0115-y
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DOI: https://doi.org/10.1007/s11859-009-0115-y