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The relationship between morning blood pressure surge and serum IGF-1 level in acromegaly patients with hypertension

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Abstract

Objective

High levels of insulin-like growth factor 1 (IGF-1) in patients with acromegaly cause structural and functional changes specific to the disease. These changes lead to mortality if the disease is not treated. Circadian blood pressure (BP) rhythm as measured by 24-h ambulatory blood pressure monitoring (ABPM) can change with a decrease in BP during sleep and a sudden increase in wakefulness.

Aim

We aim to evaluate the relationship between changes in BP and IGF-1 levels in patients with acromegaly.

Methods

Patients who were diagnosed with acromegaly and the patient group with hypertension were included. Serum biochemistry parameters, serum IGF-1 level and ABPM follow-ups were compared in these patients.

Results

In our study, 30 patients with acromegaly and 30 patients with hypertension without acromegaly were included. Thirty of the patients were male and 30 were female. There was a statistically significant difference between the groups in terms of IGF-1(p = < 0.001) and GH(p = 0.004). There was no significant difference between patients' office systolic/diastolic BP measurements, day/night, systolic/diastolic BP measurements and all systolic/diastolic BP measurements in ambulatory blood pressure follow-ups. There was a significant difference in morning blood pressure surge(p = < 0.001). A statistically significant difference was found between the acromegaly patient groups with MBPS below and above 25 mmHg in terms of IGF-1 (p = 0.025) and platelet levels (p = 0.004).

Conclusion

As a result, cardiovascular disease risks can be predicted in patients with high serum IGF-1 levels by planning ambulatory blood pressure in the early period.

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Authors and Affiliations

  1. Department of Internal Medicine, Health Science University, Adana City Research and Training Hospital, Dr. Mithat Özsan Bulvarı Kısla Neighbourhood 4522 Street No: 1 Yuregir, Adana, Turkey

    Fatih Necip Arici, Erdinc Gulumsek, Huseyin Ali Ozturk, Begum Seyda Avci & Hilmi Erdem Sumbul

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  1. Fatih Necip Arici
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  2. Erdinc Gulumsek
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  3. Huseyin Ali Ozturk
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  4. Begum Seyda Avci
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  5. Hilmi Erdem Sumbul
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Contributions

Dr. Fatih Necip Arici, Dr. Erdinc Gulumsek, Dr. Huseyin Ali Ozturk, Dr. Begum Seyda Avci, Dr. Hilmi Erdem Sumbul: conceptualization, methodology, investigation, and writing – original draft. Dr. Fatih Necip Arici, Dr. Erdinc Gulumsek, Dr. Huseyin Ali Ozturk, Dr. Begum Seyda Avci, Dr. Hilmi Erdem Sumbul: resources, formal analysis, and writing – review and editing. Dr. Fatih Necip Arici, Dr. Erdinc Gulumsek, Dr. Huseyin Ali Ozturk, Dr. Begum Seyda Avci, Dr. Hilmi Erdem Sumbul: conceptualization, methodology, and writing – review and editing. All authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Hilmi Erdem Sumbul.

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Ethical approval

The study was performed according to the recommendations set by the The Declaration of Helsinki on Medical Research involving Human Subjects. The ethics committee of Cukurova University Faculty of Medicine Clinical Research Ethics Committee approved the study.

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Informed consent was obtained from all individual participants included in the study.

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This manuscript was carried out in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines.

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The authors of this paper have no conflicts of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included.

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Arici, F.N., Gulumsek, E., Ozturk, H.A. et al. The relationship between morning blood pressure surge and serum IGF-1 level in acromegaly patients with hypertension. Ir J Med Sci 193, 233–240 (2024). https://doi.org/10.1007/s11845-023-03478-4

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  • DOI: https://doi.org/10.1007/s11845-023-03478-4

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