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Is poor sleep quality associated with lipid profile in elderly population? Finding from Iranian Longitudinal Study on Ageing

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Abstract

Background

Abnormal lipid profile as one of reversible cardiovascular disease risk factors might be affected by poor sleep quality.

Aim

This study aimed to assess the association between poor sleep quality and serum concentration of lipid profile in Iranian elderly population.

Methods

The study was performed on a representative sample of 3452 Iranian older people (≥60 years) who contributed in the Iranian Longitudinal Study on Ageing (IRLSA). Sleep quality was measured through the validated Persian version of Pittsburgh Sleep Quality Index (PSQI). Fasting blood samples were collected from the participants to measure plasma levels lipid profile. We used multiple linear regression model to evaluate the independent association of poor sleep quality with lipid profile.

Results

The mean age of participants was 68.0±6.7 years and 52.5% of them were male. In total, 52.4% of study population reported poor sleep quality (PSQI>5). Mean serum concentration of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was 143.2±74.2 mg/dl, 195.6±43.2 mg/dl, 112.9±31.0 mg/dl, and 57.3±12.4 mg/dl, respectively. Poor sleep quality was significantly associated with serum levels of TG (β=17.85; P=0.006), LDL-C (β=5.45; P=0.039) and HDL-C (β=-2.13; P=0.039) after adjusting for studied covariates.

Conclusion

Our study illustrates that poor sleep quality is a risk factor for poorer lipid profile. Therefore, early behavioral or pharmacological interventions that improve sleep quality are necessary to modify lipid profile in elderly population.

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Data availability

The data that support the findings of this study are available on request from the corresponding author.

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Acknowledgements

We would like to express our thanks to all individuals who participated in this study. Also, we gratefully acknowledge of Neyshabur Healthy Ageing Research Centre.

Funding

Funding for the present work was provided by Neyshabur University of Medical Sciences (Grant number: 2899).

Author information

Authors and Affiliations

  1. Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Mitra Hariri & Ali Gholami

  2. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Mitra Hariri, Seyed Morteza Shamshirgaran & Nayyereh Aminisani

  3. Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Seyed Morteza Shamshirgaran, Nayyereh Aminisani & Ali Gholami

  4. Public Health Department, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Hamid Abasi

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  1. Mitra Hariri
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  2. Seyed Morteza Shamshirgaran
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  3. Nayyereh Aminisani
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  4. Hamid Abasi
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  5. Ali Gholami
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Corresponding author

Correspondence to Ali Gholami.

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Ethics approval and consent to participate

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Neyshabur University of Medical Sciences (Date: 09.23.2020 /No: IR.NUMS.REC.1399.026).

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Authors declare that they have no conflict of interest.

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Hariri, M., Shamshirgaran, S.M., Aminisani, N. et al. Is poor sleep quality associated with lipid profile in elderly population? Finding from Iranian Longitudinal Study on Ageing. Ir J Med Sci 193, 123–129 (2024). https://doi.org/10.1007/s11845-023-03449-9

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  • DOI: https://doi.org/10.1007/s11845-023-03449-9

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