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Matriptase as a potential biomarker and therapeutic target in newly diagnosed type 2 diabetes mellitus

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Abstract

Background

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that affects the processing of carbohydrates, proteins, and lipids. In T2DM, metabolic dysregulation occurs through various pathways caused by increased levels of many adipokines and inflammatory chemokines. Impaired insulin-glucose metabolism occurs in tissues. The proteolytic enzyme matriptase is thought to be closely related to glucose metabolism due to its glycolization sites.

Aim

Our study aimed to evaluate the correlation between matriptase, a proteolytic enzyme, and metabolic parameters in individuals recently diagnosed with T2DM. We also sought to investigate the potential involvement of matriptase in the development of diabetes.

Methods

We measured all participants' metabolic laboratory parameters, including basic biochemical tests, hemograms, high-sensitivity C-reactive protein (hsCRP), and matriptase levels.

Results

Our results showed a significant increase in circulating matriptase levels in individuals with T2DM compared to the control group. Furthermore, individuals with metabolic syndrome had significantly higher matriptase levels than those without in the T2DM and control groups. We also observed that T2DM patients had elevated levels of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), hsCRP, and matriptase, which displayed a positive correlation.

Conclusion

Our study is the first to report elevated levels of matriptase in individuals with newly diagnosed T2DM and/or metabolic syndrome. Additionally, we found a significant positive correlation between matriptase levels and metabolic and inflammatory parameters, indicating a potential role for matriptase in the pathogenesis of T2DM and glucose metabolism. Further research on matriptase could lead to its recognition as a novel target for investigation.

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Data availability

Data and materials are reachable from hospital automation information systems.

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Funding

This study has not been funded by any organizations.

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Authors and Affiliations

  1. Department of Internal Medicine, Health Sciences University, Izmir, Bozyaka Training and Research Hospital, 35170, Karabaglar, Izmir, Turkey

    Ismail Demir & Oktay Bilgir

  2. Faculty of Medicine, Department of Pharmacology and Toxicology, Izmir Kâtip Celebi University, Izmir, Turkey

    Ismail Yilmaz & Ersan Horoz

  3. Department of General Surgery, Health Sciences University Izmir, Bozyaka Training and Research Hospital, Izmir, Turkey

    Bulent Calik

Authors
  1. Ismail Demir
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  2. Ismail Yilmaz
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  3. Ersan Horoz
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  4. Bulent Calik
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  5. Oktay Bilgir
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Contributions

Conceptualization: [Ismail Demir], [Ismail Yilmaz], [Oktay Bilgir]; Methodology: [Ismail Demir], [Ismail Yilmaz], [Oktay Bilgir]; Investigation: [Ismail Demir], [Ismail Yilmaz], [Bulent Calik]; Writing-Original Draft: [Ismail Demir], [Ismail Yilmaz], [Ersan Horoz]; Writing-Review&Editing: [Ismail Yilmaz], [Oktay Bilgir], [Bulent Calik], [Ersan Horoz]. All authors have read and approved the final version.

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Correspondence to Ismail Demir.

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This study was reviewed and approved by the institutional review board for exemption.

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Informed consent was obtained from all participants included in the study.

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The authors declare no competing interests

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Demir, I., Yilmaz, I., Horoz, E. et al. Matriptase as a potential biomarker and therapeutic target in newly diagnosed type 2 diabetes mellitus. Ir J Med Sci 193, 223–230 (2024). https://doi.org/10.1007/s11845-023-03441-3

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  • DOI: https://doi.org/10.1007/s11845-023-03441-3

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