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Association of maternal and paternal risk factors with risk of congenital heart disease in infants: a case–control study

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Abstract

Objective

We aimed to explore maternal and paternal risk factors with risk of congenital heart disease in infants.

Methods

A total of 125 congenital heart disease (CHD) infants and 125 controls were included in Heping Hospital Affiliated to Changzhi Medical College, Shanxi, China. Subjects were diagnosed between Jan 1, 2016 and Dec 31, 2021 in the present study. All the characteristics were collected with questionnaire by face-to-face interview, including maternal and paternal risk factors. Conditional logistic regression was conducted to explore the risk factors with risk of congenital heart disease in infants.

Results

For maternal risk factors, we found that age, number of pregnancies, systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI) were risk factors for CHD infants, and the ORs (95%CIs) were 1.15 (1.06–1.23) for age, 1.13 (1.02–1.29) for SBP, 1.06 (1.02–1.18) for DBP, 1.22 (1.16–1.31) for BMI. Compared with one pregnancy, the ORs (95%CIs) were 1.17 (1.05–1.29) for two pregnancies and 1.25 (1.16–1.47) for more pregnancies. For paternal risk factors, we found that age (OR = 1.07, 95%CI = 1.01–1.19), smoking (OR = 1.11, 95%CI = 1.03–1.27), drinking (OR = 1.04, 95%CI = 1.02–1.19), and BMI (OR = 1.15, 95%CI = 1.03–1.28) were risk factors for CHD infants.

Conclusion

We found that age, number of pregnancies, SBP, DBP, and BMI are maternal risk factors for CHD infants. And age, smoking, drinking, and BMI are paternal risk factors for CHD infants.

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Data availability

Data could be available on reasonable request from the corresponding author.

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Acknowledgements

The contributions of all the participants and all members of study team are greatly acknowledged.

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Authors and Affiliations

  1. Department of Preventive Health Care, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China

    Jianxia Dong & Tianyou Hao

Authors
  1. Jianxia Dong
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  2. Tianyou Hao
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Contributions

JXD and TYH designed the research, conducted the research, and performed statistical analysis. JXD wrote the paper. TYH revised the paper. TYH had primary responsibility for final content. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Tianyou Hao.

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Ethics approval

This study was approved by the Ethics and Human Subject Committee of Changzhi Medical College (no. 1754235).

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Written informed consent was obtained from all the participants.

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The authors declare no competing interests.

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Dong, J., Hao, T. Association of maternal and paternal risk factors with risk of congenital heart disease in infants: a case–control study. Ir J Med Sci 193, 95–99 (2024). https://doi.org/10.1007/s11845-023-03409-3

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  • DOI: https://doi.org/10.1007/s11845-023-03409-3

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