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Relationship between visceral adiposity index and glycemic and metabolic control in children and adolescents with type 1 diabetes mellitus

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Abstract

Background

Visceral Adiposity Index (VAI) is a gender-specific mathematical model based on BMI, waist circumference (WC) and lipid parameters. No study has yet examined the relationship between this index and the glycemic and metabolic parameters in children and adolescents with Type 1 Diabetes Mellitus (DM). The current study aims at examining the relationship between glycemic and metabolic control and VAI in children and adolescents with Type 1 DM.

Methods

A total of 150 children and adolescents aged 6–18 years with Type 1 DM were included in this study. Anthropometric, glycemic and metabolic parameters were examined. VAI was calculated using gender-specific formulas. Statistical analysis was done by SPSS version 23.

Results

The average age of the participants was 12.2 ± 3.1 years (females 53.0%). The females had higher rates of VAI, microalbuminuria and hypertension than males. Participants of both gender with higher VAI quartiles had higher anthropometric measurements, insulin usage, low-density lipoprotein cholesterol (LDL-C), triglycerides and urine microalbumin and had poor glycemic control. Sex adjusted correlation analysis showed that VAI is negatively correlated with estimated glucose disposal rate (eGDR), and positively correlated with insulin dose, LDL-C, triglycerides, glycosylated hemoglobin (HbA1c) and microalbuminuria.

Conclusion

The present paper is the first study examining the relationship between Type 1 DM and VAI. Higher VAI values in children and adolescents with type 1 DM may adversely affect glycemic and metabolic control. VAI can be a useful and new method in evaluating glycemic and metabolic control in children and adolescents with Type 1 DM.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors would like to thank the patients and their parents who participated in this study.

Author information

Authors and Affiliations

  1. Department of Nutrition and Dietetics, Istanbul Medipol University School of Health Sciences, Istanbul, Turkey

    Volkan Özkaya

  2. Department of Nutrition and Dietetics, Fenerbahce University School of Health Sciences, Istanbul, Turkey

    Şebnem Özgen Özkaya

  3. Faculty of Medicine, Department of Pediatric Endocrinology, Istanbul Medipol University, Istanbul, Turkey

    Servet Erdal Adal

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Contributions

V.Ö., Ş.Ö.Ö, S.E.A.; contributed to the main study idea and design, V.Ö, Data Collection and/or Processing-Analysis and/or Interpretation, V.Ö, Ş.Ö.Ö, wrote the first draft of the manuscript. Ş.Ö.Ö., S.E.A.; revised and edited the manuscript. V.Ö., Ş.Ö.Ö, S.E.A.; Critical Review. All the authors approved the final submitted manuscript.

Corresponding author

Correspondence to Volkan Özkaya.

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Ethics

The ethics committee approval no. 2018-14/38 was obtained from Bursa Uludağ University Non-Interventional Clinical Research Ethics Committee and the research permit no. 73115338-819/38160 was obtained from Bursa Uludağ University Directorate for Health Applied and Research Center. The study conformed to the provision of the Declaration of Helsinki.

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The authors declare no conflict of interest.

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Özkaya, V., Özkaya, Ş.Ö. & Adal, S.E. Relationship between visceral adiposity index and glycemic and metabolic control in children and adolescents with type 1 diabetes mellitus. Ir J Med Sci 193, 181–189 (2024). https://doi.org/10.1007/s11845-023-03375-w

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