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Diagnostic value of pseudocapsule ring hyperenhancement in contrast-enhanced ultrasound in renal focal lesions

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Abstract

Object

To investigate the diagnostic value of pseudocapsule ring hyperenhancement in contrast-enhanced ultrasound (CEUS) of focal renal lesions.

Method

Ninety eligible patients admitted were selected as the study subjects. The incidence rate of annular hyperenhancement in different benign and malignant focal lesions during angiography and the shape of annular enhancement were counted. The correlation between the occurrence of benign and malignant renal tumors and annular hyperenhancement and unenhanced areas was also analyzed.

Results

Capsule enhancement was observed in 56 cases, including 50 cases of malignant tumors (89.3%, 50/56) and 6 cases of benign tumors (10.7%, 6/56). Pearson correlation analysis showed that renal malignancy was positively associated with the occurrence of pseudocapsule ring hyperenhancement (γ = 0.489, P < 0.001). Benign and malignant renal tumors were positively correlated with the occurrence of non-enhancing areas (γ = 0.215, P = 0.042). The thickness and peak intensity of pseudocapsule ring enhancement in renal malignant tumors were significantly higher than those in benign tumors (all P < 0.001), while the time to peak was significantly lower than that in benign tumors (P < 0.001). The results of receiver operating characteristic (ROC) curve showed that the ring enhancement thickness, time to peak, and area under ROC curve of peak intensity of tumor reached more than 0.9.

Conclusion

In CEUS, the pseudocapsule of focal renal lesions is a characteristic feature of renal malignant tumors, which can be used as a differential basis for benign and malignant tumors to improve the accuracy of benign and malignant renal tumors.

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Funding

This project has been supported by the Zhejiang Provincial Health Department Project (no. 2021KY494), the Natural Science Foundation of Zhejiang Province (no. LY18H150005), and the Scientific Foundation of Zhejiang Provincial Ministry of Education (no. Y202044691).

Author information

Authors and Affiliations

  1. Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Zhejiang Province, Hangzhou, 310000, People’s Republic of China

    Ligang Wang, Jianchun Li, Yang Liu & Litao Sun

  2. Department of Ultrasound Medicine, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou, 310000, People’s Republic of China

    Hao Wu

  3. Health Management Center, Health Promotion Center, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Zhejiang Province, Hangzhou, 310000, People’s Republic of China

    Ying Wang

  4. Bengbu Medical College, Anhui Province, 230030, Bengbu, People’s Republic of China

    Tingting Zhang & Zhaowang Tan

  5. Ultrasound Department, Zhejiang Hospital affiliated to Zhejiang, University School of Medicine, Zhejiang Province, Hangzhou, 310013, People’s Republic of China

    Han Wang

  6. Department of Ultrasound Medicine, Cancer HospitalAffiliated to, University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) , Zhejiang Province, Hangzhou, 310000, People’s Republic of China

    Dong Xu

  7. Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Zhejiang Province, Hangzhou, 310000, People’s Republic of China

    Jianfeng Tu

Authors
  1. Ligang Wang
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  2. Hao Wu
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  4. Ying Wang
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  7. Yang Liu
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  8. Han Wang
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  9. Litao Sun
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  10. Dong Xu
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  11. Jianfeng Tu
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Contributions

LW conceived and designed the study; HW collected the data; JL analyzed and interpreted the data; LW, HW, and JL wrote the manuscript; YW, TZ ZT, YL, and HW provided critical revisions that are important for the intellectual content; and LS, DX, and JT revised and approved the final version of the manuscript.

Corresponding authors

Correspondence to Litao Sun, Dong Xu or Jianfeng Tu.

Ethics declarations

Ethics approval and consent to participate

All recruited patients agreed to conduct the study, and this study were approved by the ethical committee of Zhejiang Provincial People’s Hospital.

Consent for publication

All patients recruited agreed for the publication.

Competing interests

The authors declare no competing interests.

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Ligang Wang, Hao Wu, and Jianchun Li contributed equally to this study.

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Cite this article

Wang, L., Wu, H., Li, J. et al. Diagnostic value of pseudocapsule ring hyperenhancement in contrast-enhanced ultrasound in renal focal lesions. Ir J Med Sci 192, 1631–1636 (2023). https://doi.org/10.1007/s11845-023-03320-x

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  • DOI: https://doi.org/10.1007/s11845-023-03320-x

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