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Comparison of ultrasound-guided pulsed radiofrequency versus steroid injection in the treatment of carpal tunnel syndrome

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Abstract

Background

Carpal tunnel syndrome (CTS) is the most widespread form of nerve entrapment neuropathy results from increase compression pressure of the median nerve at the wrist under the transverse carpal ligament.

Aims

To compare ultrasound (US)-guided median nerve steroid injection and pulsed radiofrequency (PRF) on pain intensity, functional status, and patient satisfaction in the treatment of CTS.

Methods

A total of 90 hands of 59 patients who underwent steroid injection at the level of proximal carpal tunnel or PRF for CTS were retrospectively analyzed. Demographic and clinical characteristics of the patients were recorded. The pain severity was assessed using the Numerical Rating Scale (NRS), and the functional status and clinical outcomes were assessed using the Boston Carpal Tunnel Questionnaire (BCTQ) before the procedure and at Week 1, Month 1, and Month 3 after the procedure. Time to pain relief was evaluated at week 1. Patient satisfaction was evaluated at Month 3.

Results

There was no significant difference in the NRS and BCTQ scores between the two treatment methods (p > 0.05 for both). In addition, a significant decrease in the NRS and BCTQ scores were detected at all follow-ups compared to baseline in treatment groups (p < 0.001). The mean time to pain relief was significantly shorter in the PRF group (p < 0.001). Patient satisfaction was similar at Month 3 between the treatment methods (p > 0.05).

Conclusions

Our study results suggest that both US-guided steroid injection to the median nerve and PRF are effective and safe methods in the short-term in the treatment of CTS.

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References

  1. Ly-Pen D, Andreu JL, Millán I et al (2020 )Long-term outcome of local steroid injections versus surgery in carpal tunnel syndrome: observational extension of a randomized clinical trial Hand (NY) 1558944720944263 https://doi.org/10.1177/1558944720944263

  2. Wang JC, Liao KK, Lin KP et al (2017) Efficacy of combined ultrasound-guided steroid injection and splinting in patients with carpal tunnel syndrome: a randomized controlled trial. Arch Phys Med Rehabil 98(5):947–956

    Article  PubMed  Google Scholar 

  3. Aroori S, Spence RA (2008) Carpal tunnel syndrome. Ulster Med J 77(1):6–17

    PubMed  PubMed Central  Google Scholar 

  4. Babaei-Ghazani A, Nikbakht N, Forogh B et al (2018) Comparison between effectiveness of ultrasound-guided corticosteroid injection above versus below the median nerve in mild to moderate carpal tunnel syndrome: a randomized controlled trial. Am J Phys Med Rehabil 97(6):407–413. https://doi.org/10.1097/PHM.0000000000000877

    Article  PubMed  Google Scholar 

  5. Karadas O, Tok F, Ulas UH et al (2011) The effectiveness of triamcinolone acetonide vs. procaine hydrochloride injection in the management of carpal tunnel syndrome: a double-blind randomized clinical trial. Am J Phys Med Rehabil 90(4):287–292. https://doi.org/10.1097/PHM.0b013e31820639ec

  6. Chen LC, Ho CW, Sun CH et al (2015) Ultrasound-guided pulsed radiofrequency for carpal tunnel syndrome: a single-blinded randomized controlled study. PLoS ONE 10(6):e0129918. https://doi.org/10.1371/journal.pone.0129918

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Padua L, Coraci D, Erra C et al (2016) Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol 15(12):1273–1284. https://doi.org/10.1016/S1474-4422(16)30231-9

    Article  PubMed  Google Scholar 

  8. Roh YH, Hwangbo K, Gong HS et al (2019) Comparison of ultrasound-guided versus landmark-based corticosteroid injection for carpal tunnel syndrome: a prospective randomized trial. J Hand Surg Am 44(4):304–310. https://doi.org/10.1016/j.jhsa.2019.02.007

    Article  PubMed  Google Scholar 

  9. Armstrong T, Devor W, Borschel L et al (2004) Intracarpal steroid injection is safe and effective for short-term management of carpal tunnel syndrome. Muscle Nerve 29(1):82–88

    Article  CAS  PubMed  Google Scholar 

  10. Eslamian F, Eftekharsadat B, Babaei-Ghazani A et al (2017) A randomized prospective comparison of ultrasound-guided and landmark-guided steroid injections for carpal tunnel syndrome. J Clin Neurophysiol 34(2):107–113. https://doi.org/10.1097/WNP.0000000000000342

    Article  PubMed  Google Scholar 

  11. Karaahmet OZ, Gurcay E, Kara M et al (2017) Comparing the effectiveness of ultrasound-guided versus blind steroid injection in the treatment of severe carpal tunnel syndrome. Turk J Med Sci 47(6):1785–1790. https://doi.org/10.3906/sag-1704-97

    Article  CAS  PubMed  Google Scholar 

  12. Makhlouf T, Emil NS, Sibbitt WL et al (2014) Outcomes and cost-effectiveness of carpal tunnel injections using sonographic needle guidance. Clin Rheumatol 33(6):849–858. https://doi.org/10.1007/s10067-013-2438-5

    Article  PubMed  Google Scholar 

  13. Chang MC (2018) Efficacy of pulsed radiofrequency stimulation in patients with peripheral neuropathic pain: a narrative review. Pain Physician 21(3):E225-e234

    Article  PubMed  Google Scholar 

  14. Chua NH, Vissers KC, Sluijter ME (2011) Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications-a review. Acta Neurochir 153(4):763–771. https://doi.org/10.1007/s00701-010-0881-5

    Article  PubMed  Google Scholar 

  15. So H, Chung VCH, Cheng JCK et al (2018) Local steroid injection versus wrist splinting for carpal tunnel syndrome: A randomized clinical trial. Int J Rheum Dis 21(1):102–107

    Article  CAS  PubMed  Google Scholar 

  16. Sezgin M, Incel NA, Serhan S et al (2006) Assessment of symptom severity and functional status in patients with carpal tunnel syndrome: reliability and functionality of the Turkish version of the Boston Questionnaire. Disabil Rehabil 28(20):1281–1285

    Article  PubMed  Google Scholar 

  17. Kim DH, Jang JE, Park BK (2013) Anatomical basis of ulnar approach in carpal tunnel injection. Pain Physician 16(3):E191-198

    Article  PubMed  Google Scholar 

  18. Hsu PC, Liao KK, Lin KP et al (2020) Comparison of corticosteroid injection dosages in mild to moderate idiopathic carpal tunnel syndrome: a randomized controlled trial. Arch Phys Med Rehabil 101(11):1857–1864. https://doi.org/10.1016/j.apmr.2020.06.018

    Article  PubMed  Google Scholar 

  19. Karimzadeh A, Bagheri S, Raeissadat SA et al (2019) The comparison of the effectiveness between different doses of local methylprednisolone injection versus triamcinolone in Carpal Tunnel Syndrome: a double-blind clinical trial. J Pain Res 12:579–584

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Chesterton LS, Blagojevic-Bucknall M, Burton C et al (2018) The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. Lancet 392(10156):1423–1433

    Article  PubMed  PubMed Central  Google Scholar 

  21. Moghtaderi AR, Moghtaderi N, Loghmani A (2011) Evaluating the effectiveness of local dexamethasone injection in pregnant women with carpal tunnel syndrome. J Res Med Sci 16(5):687–690

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Buntragulpoontawee M, Chang KV, Vitoonpong T et al (2020) The effectiveness and safety of commonly used injectates for ultrasound-guided hydrodissection treatment of peripheral nerve entrapment syndromes: a systematic review. Front Pharmacol 11:621150. https://doi.org/10.3389/fphar.2020.621150

    Article  CAS  PubMed  Google Scholar 

  23. Salman Roghani R, Holisaz MT, Tarkashvand M et al (2018) Different doses of steroid injection in elderly patients with carpal tunnel syndrome: a triple-blind, randomized, controlled trial. Clin Interv Aging 13:117–124

    Article  PubMed  PubMed Central  Google Scholar 

  24. Brinks A, Koes BW, Volkers AC et al (2010) Adverse effects of extra-articular corticosteroid injections: a systematic review. BMC Musculoskelet Disord 11:206

    Article  PubMed  PubMed Central  Google Scholar 

  25. Haider N, Mekasha D, Chiravuri S et al (2007) Pulsed radiofrequency of the median nerve under ultrasound guidance. Pain Physician 10(6):765–770

    Article  PubMed  Google Scholar 

  26. Mercadal B, Vicente R, Ivorra A (2020) Pulsed radiofrequency for chronic pain: In vitro evidence of an electroporation mediated calcium uptake. Bioelectrochemistry 136:107624.

  27. Hagiwara S, Iwasaka H, Takeshima N et al (2009) Mechanisms of analgesic action of pulsed radiofrequency on adjuvant-induced pain in the rat: roles of descending adrenergic and serotonergic systems. Eur J Pain 13(3):249–252

    Article  CAS  PubMed  Google Scholar 

  28. Vallejo R, Tilley DM, Williams J et al (2013) Pulsed radiofrequency modulates pain regulatory gene expression along the nociceptive pathway. Pain Physician 16(5):E601-613

    Article  PubMed  Google Scholar 

  29. McConnell JR, Bush DC (1990) Intraneural steroid injection as a complication in the management of carpal tunnel syndrome. A report of three cases. Clin Orthop Relat Res 250:181–184

    Article  Google Scholar 

  30. Ustun N, Tok F, Yagiz AE et al (2013) Ultrasound-guided vs. blind steroid injections in carpal tunnel syndrome: A single-blind randomized prospective study. Am J Phys Med Rehabil 92(11):999–1004. https://doi.org/10.1097/PHM.0b013e31829b4d72

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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Alp Eren Çelenlioğlu, Hanzade Aybüke Ünal Artık, and Gülen Güler. The manuscript was written by Alp Eren Çelenlioğlu. All authors read and approved the final manuscript.

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Correspondence to Alp Eren Celenlioglu.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Written informed consent was obtained from all patients.

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Celenlioglu, A.E., Unal-Artık, H.A. & Guler, G. Comparison of ultrasound-guided pulsed radiofrequency versus steroid injection in the treatment of carpal tunnel syndrome. Ir J Med Sci 191, 2751–2757 (2022). https://doi.org/10.1007/s11845-022-02923-0

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  • DOI: https://doi.org/10.1007/s11845-022-02923-0

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