Abstract
Background
Iodine-131 is an effective treatment for thyrotoxicosis. In 2019, National Institute for Clinical Excellence guidelines (UK) suggested offering radioactive iodine as first-line definitive treatment for adults with Graves' disease, toxic nodular and multinodular goitre unless it is unsuitable or anti-thyroid drugs are likely to achieve remission. The aim of this study was to evaluate the clinical outcome 1 year after using fixed-dose Iodine-131 for hyperthyroidism and time (months) to response.
Methods
Electronic patient records were studied retrospectively for all patients who were treated with radioiodine therapy for hyperthyroidism between July 2017 and March 2020 at a district general hospital in the UK. Response to radioiodine therapy was initially assessed at 6 weeks and then at 3, 6, and 12 months by a dedicated thyroid nurse-led virtual follow-up.
Results
We identified 67 patients with a mean age of 55.9 years (range 18-84); 48 (72%) females, 19 (28%) males. Of these, 57 (85%) patients were cured at 12 months (93.7% in non-Graves', 82.3% in Graves' group). Gender, diagnosis and pre-treatment disease interval were not significantly associated with treatment success. Non-Graves' patients had a significantly shorter time to discharge than Graves' patients receiving Iodine-131 (8 versus 10.3 months, p = 0.0174).
Conclusion
The results of the present study demonstrate that a single fixed dose of Iodine-131 therapy is highly effective and comparable to outcomes from calculated dose therapy in literature. We propose the routine use of scoring system to calculate risk of relapse for all newly diagnosed hyperthyroid patients to tailor treatment modality.
References
Tunbridge WM, Evered DC, Hall R et al (1977) The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7(6):481–493. https://doi.org/10.1111/j.1365-2265.1977.tb01340.x
UK Guidelines for the Use of Thyroid Function Tests (2006) https://www.british-thyroid-association.org/sandbox/bta2016/uk_guidelines_for_the_use_of_thyroid_function_tests.pdf. Accessed July 2006
Abraham P, Avenell A, McGeoch SC et al (2010) Antithyroid drug regimen for treating Graves’ hyperthyroidism. Cochrane Database Syst Rev 2010 (1):Cd003420. https://doi.org/10.1002/14651858.CD003420.pub4
Abraham-Nordling M, Törring O, Hamberger B et al (2005) Graves’ disease: a long-term quality-of-life follow up of patients randomized to treatment with antithyroid drugs, radioiodine, or surgery. Thyroid 15(11):1279–1286. https://doi.org/10.1089/thy.2005.15.1279
Bahn Chair RS, Burch HB, Cooper DS et al (2011) Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid 21(6):593–646. https://doi.org/10.1089/thy.2010.0417
Read CH Jr, Tansey MJ, Menda Y (2004) A 36-year retrospective analysis of the efficacy and safety of radioactive iodine in treating young Graves’ patients. J Clin Endocrinol Metab 89(9):4229–4233. https://doi.org/10.1210/jc.2003-031223
Ross DS, Burch HB, Cooper DS et al (2016) American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid 26(10):1343–1421. https://doi.org/10.1089/thy.2016.0229
Bartalena L, Chiovato L, Vitti P (2016) Management of hyperthyroidism due to Graves’ disease: frequently asked questions and answers (if any). J Endocrinol Invest 39(10):1105–1114. https://doi.org/10.1007/s40618-016-0505-x
Wang J, Qin L (2016) Radioiodine therapy versus antithyroid drugs in Graves’ disease: a meta-analysis of randomized controlled trials. Br J Radiol 89(1064):20160418. https://doi.org/10.1259/bjr.20160418
Excellence NIoHaC (2019) Thyroid disease: assessment and management. https://www.nice.org.uk/guidance/NG145.
Törring O, Tallstedt L, Wallin G et al (1996) Graves’ hyperthyroidism: treatment with antithyroid drugs, surgery, or radioiodine--a prospective, randomized study. Thyroid Study Group. J Clin Endocrinol Metab 81 (8):2986–2993. https://doi.org/10.1210/jcem.81.8.8768863
Wong KK, Shulkin BL, Gross MD, Avram AM (2018) Efficacy of radioactive iodine treatment of Graves’ hyperthyroidism using a single calculated (131) I dose. Clin Diabetes Endocrinol 4:20. https://doi.org/10.1186/s40842-018-0071-6
Kartamihardja A, Massora S (2016) The influence of antithyroid drug discontinuation to the therapeutic efficacy of <sup>131</sup> I in hyperthyroidism. World Journal of Nuclear Medicine 15(2):81–84. https://doi.org/10.4103/1450-1147.167584
Thyroid disease: assessment and management. [I] Management of thyrotoxicosis: -drugs vs surgery vs radioactive iodine-safety of treatment with radioactive iodine. (2019). https://www.nice.org.uk/guidance/ng145/evidence/i-management-of-thyrotoxicosis-drugs-vs-surgery-vs-radioactive-iodine-safety-of-treatment-with-radioactive-iodine-pdf-6967421685.
Metso S, Jaatinen P, Huhtala H et al (2004) Long-term follow-up study of radioiodine treatment of hyperthyroidism. Clin Endocrinol (Oxf) 61(5):641–648. https://doi.org/10.1111/j.1365-2265.2004.02152.x
Tarantini B, Ciuoli C, Di Cairano G et al (2006) Effectiveness of radioiodine (131-I) as definitive therapy in patients with autoimmune and non-autoimmune hyperthyroidism. J Endocrinol Invest 29(7):594–598. https://doi.org/10.1007/bf03344157
de Rooij A, Vandenbroucke JP, Smit JW et al (2009) Clinical outcomes after estimated versus calculated activity of radioiodine for the treatment of hyperthyroidism: systematic review and meta-analysis. Eur J Endocrinol 161(5):771–777. https://doi.org/10.1530/eje-09-0286
Abraham P, Acharya S (2010) Current and emerging treatment options for Graves’ hyperthyroidism. Ther Clin Risk Manag 6:29–40. https://doi.org/10.2147/tcrm.s5229
Vijayakumar V, Ali S, Nishino T, Nusynowitz M (2006) What influences early hypothyroidism after radioiodine treatment for Graves’ hyperthyroidism? Clin Nucl Med 31:688–689
Liu M, Jing D, Hu J, Yin S (2014) Predictive factors of outcomes in personalized radioactive iodine ((131)I) treatment for Graves’ disease. Am J Med Sci 348(4):288–293. https://doi.org/10.1097/maj.0000000000000288
Masiello E, Veronesi G, Gallo D et al (2018) Antithyroid drug treatment for Graves’ disease: baseline predictive models of relapse after treatment for a patient-tailored management. J Endocrinol Invest 41(12):1425–1432. https://doi.org/10.1007/s40618-018-0918-9
Aung A, Zammitt N, Dover A et al (2018) Predicting outcomes and complications following radioiodine therapy in Graves’ thyrotoxicosis Clin Endocrinol 90 https://doi.org/10.1111/cen.13873
Erem C, Kandemir N, Hacihasanoglu A et al (2004) Radioiodine treatment of hyperthyroidism: prognostic factors affecting outcome. Endocrine 25(1):55–60. https://doi.org/10.1385/endo:25:1:55
Ghadban WK, Zirie MA, Al-Khateeb DA et al (2003) Radioiodine treatment of hyperthyroidism. Success rate and influence of thyrostatic medication. Saudi Med J 24(4):347–351
Nahar K, Akhter P (2018) Factors affecting and outcome of radioactive iodine therapy in hyperthyroidism: a study at Institute of Nuclear Medicine & Allied Sciences (INMAS). Sylhet Bangladesh J Nucl Med 19:19. https://doi.org/10.3329/bjnm.v19i1.35568
Tay WL, Chng CL, Tien CS et al (2019) High thyroid stimulating receptor antibody titre and large goitre size at first-time radioactive iodine treatment are associated with treatment failure in Graves’ disease. Ann Acad Med Singap 48(6):181–187
Park H, Kim HI, Park J et al (2020) The success rate of radioactive iodine therapy for Graves’ disease in iodine-replete area and affecting factors: a single-center study. Nucl Med Commun 41(3):212–218. https://doi.org/10.1097/mnm.0000000000001138
Struja T, Kaeslin M, Boesiger F et al (2017) External validation of the GREAT score to predict relapse risk in Graves’ disease: results from a multicenter, retrospective study with 741 patients. Eur J Endocrinol 176(4):413–419. https://doi.org/10.1530/eje-16-0986
Lu L, Gao C, Zhang N (2021) Age moderates the associations between TRAbs, free T3 and outcomes of Graves’ disease patients with radioactive iodine treatment. Clin Endocrinol (Oxf) 94(2):303–309. https://doi.org/10.1111/cen.14301
Quadbeck B, Hoermann R, Roggenbuck U et al (2005) Sensitive thyrotropin and thyrotropin-receptor antibody determinations one month after discontinuation of antithyroid drug treatment as predictors of relapse in Graves’ disease. Thyroid 15(9):1047–1054. https://doi.org/10.1089/thy.2005.15.1047
Kahaly GJ, Diana T, Kanitz M et al (2019) Prospective trial of functional thyrotropin receptor antibodies in Graves disease. J Clin Endocrinol Metab 105(4):e1006–e1014. https://doi.org/10.1210/clinem/dgz292
Acknowledgements
The authors would like to thank Violet Fazal-Sanderson, specialist senior staff nurse from the Department of Endocrinology, Royal Berkshire NHS Foundation Trust.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Nair, D., Maweni, R., Constantinou, C. et al. Clinical efficacy of fixed-dose radioactive iodine for the treatment of hyperthyroidism at a single centre: our experience. Ir J Med Sci 191, 1659–1665 (2022). https://doi.org/10.1007/s11845-021-02767-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11845-021-02767-0