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Mean platelet volume/platelet count ratio as a predictor of stent thrombosis in patients with ST-segment–elevation myocardial infarction

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Abstract

Background

Despite the important role of some haematological parameters in tendency to thrombosis is known, their relationship with long-term stent thrombosis (ST) remains unclear.

Aims

This study aimed to investigate the association between the mean platelet volume (MPV) to platelet count (PC) ratio and long-term ST and mortality in patients with ST-segment–elevation myocardial infarction (STEMI) treated successfully by primary percutaneous coronary intervention (pPCI).

Methods

In a retrospective cohort study, according to their baseline MPV/PC ratios, 3667 consecutive STEMI patients undergoing pPCI were divided into three groups: tertile 1 (T1) (n = 1222, 0.357 ≥ MPV/PC ≥ 0.043), tertile 2 (T2) (n = 1222, 0.033 < MPV/PC < 0.043) and tertile 3 (T3) (n = 1223, 0.009 ≤ MPV/PC ≤ 0.032). Patients were followed up with for 5 years, focusing on ST and all-cause mortality outcomes.

Results

Patients with T1 displayed a greater 5-year ST rate, including a 2.76-fold greater (95% confidence interval 1.68–10.33) rate than that of patients with T3, who had the lowest rates and were used as the reference group. Meanwhile, the 5-year mortality rate was similarly higher among patients with T1 by 1.72 times (95% confidence interval 1.33–2.22) relative to that among patients with T3. These significant relationships persisted even after adjustment for all confounders.

Conclusion

We found that higher MPV/PC ratios were associated with long-term ST and mortality. The MPV/PC ratio may constitute both a rapid and an easily obtainable parameter for identifying reliably high-risk patients who have undergone pPCI.

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Authors and Affiliations

  1. Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Tibbiye cad. 13, Haydarpasa, Istanbul, Turkey

    Altuğ Ösken, Recep Hacı, Lale Dinç Asarcıklı, Mehmet Erdinç Arıkan, Tolga Onuk, Şennur Ünal Dayı & Neşe Çam

  2. Department of Cardiology, Yalova State Hospital, Yalova, Turkey

    Recep Hacı

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  1. Altuğ Ösken
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  2. Recep Hacı
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  3. Lale Dinç Asarcıklı
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  7. Neşe Çam
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Corresponding author

Correspondence to Altuğ Ösken.

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Ethical approval

This study was carried out in accordance with the Declaration of Helsinki and was approved by the institutional review board of Haydarpasa Numune Training and Research Hospital (ref. no. 2021/82).

Infromed consent

Written informed consent from the patients was obtained during their hospitalisation.

Conflict of interest

The authors declare no competing interests.

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Ösken, A., Hacı, R., Dinç Asarcıklı, L. et al. Mean platelet volume/platelet count ratio as a predictor of stent thrombosis in patients with ST-segment–elevation myocardial infarction. Ir J Med Sci 190, 1095–1102 (2021). https://doi.org/10.1007/s11845-021-02626-y

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  • DOI: https://doi.org/10.1007/s11845-021-02626-y

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