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Effect of post-perfusion hyperoxemia on early graft function in renal transplant recipients: a retrospective observational cohort study

Irish Journal of Medical Science (1971 -) volume 190, pages 1539–1545 (2021)Cite this article

Abstract

Background

The effects of hyperoxemia on the transplanted grafts arouse interest nowadays, particularly intraoperative hyperoxemia, on transplant kidney function and survival in the 1-year post-operative period.

Aims

We aimed to investigate the effect of post-perfusion (5 min after perfusion) hyperoxemia on early graft function and survival in renal transplant recipients.

Methods

Two hundred forty-seven living donor kidney transplant recipients were included in the study. Patients were divided into the three groups according to their partial arterial oxygen pressure in post-perfusion blood gas samples: group 1: normoxia (n = 52, PaO2 pressure: < 120 mmHg, 103 ± 13); group 2: moderate hyperoxemia (n = 121, PaO2: 120–200 mmHg, 169 ± 21); group 3: severe hyperoxemia (n = 74, PaO2: > 200 mmHg, 233 ± 25). Graft functions (serum creatinine levels, estimated-glomerular filtration rate values, spot urine protein/creatinine ratio), survival rates, and groups’ clinical outcomes were compared in the first year after transplantation.

Results

Graft survival rates were similar in the groups and the rate of BK virus viremia was the lowest in the group 3 (groups 1, 2, and 3: 15.4% (n = 8), 6.6% (n = 8), 1.4% (n = 1), respectively, P: 0.009). Serum creatinine and proteinuria levels were lower, and estimated-glomerular filtration rate values were higher in group 3. A negative correlation between partial arterial oxygen pressure and serum creatinine levels and a positive correlation with estimated-glomerular filtration rate value were noted. These results were confirmed by univariate and multivariate analyses.

Conclusions

We demonstrated that the kidney transplant recipients with post-perfusion hyperoxemia have better early graft functions and lower BK virus viremia rates.

Trial registration

ClinicalTrials.gov Identifier: NCT04420897

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Data availability

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Author information

Affiliations

  1. Department of Anaesthesiology and Reanimation, Akdeniz University Medical School, Antalya, Turkey

    Bora Dinc, İlker O. Aycan, Necmiye Hadimioglu & Zeki Ertug

  2. Division of Nephrology, Department of Internal Medicine, Akdeniz University Medical School, Antalya, Turkey

    Vural T. Yilmaz

  3. Department of General Surgery, Akdeniz University Medical School, Antalya, Turkey

    Abdullah Kisaoglu, Ozgur Dandin & Bulent Aydinli

Authors
  1. Bora Dinc
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  2. Vural T. Yilmaz
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  3. İlker O. Aycan
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  4. Abdullah Kisaoglu
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  5. Ozgur Dandin
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  6. Bulent Aydinli
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  7. Necmiye Hadimioglu
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  8. Zeki Ertug
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Contributions

BD contributed in conducting the study, data acquisition and analysis, and preparation of the manuscript and revision. VTY supervised the research and is the corresponding author. IOA contributed to the study design, data analysis, and revision. AK contributed to laboratory and statistical analysis, study design, and revision. OD and BA identified and followed up patients for the study. NH and ZE supervised the research. All authors reviewed the final version of the manuscript and agreed to its content before submission.

Corresponding author

Correspondence to Vural T. Yilmaz.

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The authors declare that they have no conflict of interest.

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Dinc, B., Yilmaz, V.T., Aycan, İ.O. et al. Effect of post-perfusion hyperoxemia on early graft function in renal transplant recipients: a retrospective observational cohort study. Ir J Med Sci 190, 1539–1545 (2021). https://doi.org/10.1007/s11845-020-02499-7

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  • DOI: https://doi.org/10.1007/s11845-020-02499-7

Keywords

  • Glomerular filtration rate
  • Graft function
  • Hyperoxemia
  • Renal transplantation