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Anxiety and depression in glioma patients: prevalence, risk factors, and their correlation with survival

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Abstract

Aims

This study aimed to investigate the risk factors and prognostic value of anxiety and depression in glioma patients.

Methods

A total of 190 glioma patients who underwent resection were consecutively enrolled. Anxiety was assessed using hospital anxiety and depression scale (HADS) and Zung self-rating anxiety scale (SAS); depression was assessed with the use of HADS and Zung self-rating depression scale (SDS). All patients were followed up to death or 36 months. Overall survival (OS) was calculated according to the survival data.

Results

The prevalence of anxiety ranged from 36.3 to 37.4%, and the prevalence of depression ranged from 28.4 to 32.6% based on different assessment scales. Female, diabetes, and increased WHO grade were correlated with HADS anxiety and SAS anxiety, while female, single/divorced/widowed status, hyperlipidemia, diabetes, and CKD were associated with HADS depression and SDS depression. Further multivariate logistic analyses disclosed the following: single/divorced/widowed status and WHO grade were independent risk factors for HADS anxiety; female and hyperlipidemia were independent risk factors for SAS anxiety; whereas education duration (< 12 years), single/divorced/widowed status, and CKD were independent risk factors for HADS depression; female, single/divorced/widowed status, and hyperlipidemia were independent risk factors for SDS depression. Besides, HADS anxiety, SAS anxiety and SDS depression were correlated with shorter OS, while HADS depression was not.

Conclusions

Our findings about the risk factors and prognostic value of anxiety and depression might aid for their early prevention and prognosis improvement in glioma patients.

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Authors and Affiliations

  1. Department of Strategy and Business Development, Henan Cancer Hospital, Zhengzhou, Henan, People’s Republic of China

    Aiping Hao

  2. Department of Neurosurgery, Henan Cancer Hospital, 127 Dongming Road, Zhengzhou, 450008, Henan, People’s Republic of China

    Junling Huang & Xin Xu

Authors
  1. Aiping Hao
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  2. Junling Huang
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  3. Xin Xu
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Correspondence to Xin Xu.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Institutional Review Board of Henan Cancer Hospital approved this study.

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Hao, A., Huang, J. & Xu, X. Anxiety and depression in glioma patients: prevalence, risk factors, and their correlation with survival. Ir J Med Sci 190, 1155–1164 (2021). https://doi.org/10.1007/s11845-020-02374-5

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  • DOI: https://doi.org/10.1007/s11845-020-02374-5

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