Abstract
Background
The current study aims to evaluate the effects of daily traditional experiential music listening for clinical recovery of post-stroke aphasia.
Methods
This was a prospective randomized trial with seventy-nine stroke survivors who suffered from post-stroke aphasia. All patients underwent a neuropsychological evaluation, at time = 0 during the admission at the rehabilitation structure (baseline), and 6 months post-stroke. All cases received standard treatment for stroke and post-stroke aphasia in terms of medical care and rehabilitation. Furthermore, patients were randomized to receive either standard care only or standard care with daily traditional experiential music listening. Computer tomography perfusion and neurological examination were assessed to all patients. Recovery was measured by the score at Aachener Aphasie Test.
Results
The statistically significant differences between the control group (CG) and the rest of the patients were the clinical characteristics (hemiparesis) (p = 0.002), the cerebral blood flow in affected areas (p = 0.000), and the Mini-Mental Test (mMT) (p = 0.000). Only group and mMT were independent predictor factors for recovery, according to multivariate analysis odd ratio (ΟR) (95% confidence interval) 0.022 (0.009–0.435) and 0.658 (0.142–0.224) respectively.
Conclusions
The results of this study are promising and suggest that an enriched sound environment is beneficial for patients with post-stroke aphasia since the recovery rate is higher when standard care was combined with daily music listening.
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References
Lindsay MP, Norrving B, Sacco RL, Brainin M, Hacke W, Martins S, Pandian J, Feigin V (2019) World Stroke Organization (WSO): global stroke fact sheet 2019. Int J Stroke 14(8):806–817
Lackland DT, Roccella EJ, Deutsch AF, et al (2013) On behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Quality of Care and Outcomes Research, and Council on Genomic and Precision Medicine. Factors influencing the decline in stroke mortality: a statement from the American Heart Association/American Stroke Association. Stroke
Murray CJ, Vos T, Lozano R et al (2013) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 381(9867):628
Berthier ML (2005) Poststroke aphasia: epidemiology, pathophysiology, and treatment. Drugs Aging 22(2):163–182
Inatomi Y, Yonehara T, Omiya S, Hashimoto Y, Hirano T, Uchino M (2008) Aphasia during the acute phase in ischemic stroke. Cerebrovasc Dis 25(4):316–323
Ellis C, Simpson AN, Bonilha H, Mauldin PD, Simpson KN (2012) The one-year attributable cost of poststroke aphasia. Stroke. 43(5):1429–1431
Doogan C, Dignam J, Copland D, Leff A (2018) Aphasia recovery: when, how and who to treat? Curr Neurol Neurosci Rep 18(12):90
Brady MC, Kelly H, Godwin J et al (2016) Speech and language therapy for aphasia following stroke. Cochrane Database Syst Rev 6:CD000425
Stahl B, Mohr B, Büscher V, Dreyer FR, Lucchese G, Pulvermüller F (2018) Efficacy of intensive aphasia therapy in patients with chronic stroke: a randomized controlled trial. J Neurol Neurosurg Psychiatry 89(6):586–592
Saxena S, Hillis AE (2017) An update on medications and noninvasive brain stimulation to augment language rehabilitation in post-stroke aphasia. Expert Rev Neurother 17(11):1091–1107
Fridriksson J, Rorden C, Elm J, Sen S, George MS, Bonilha L (2018) Transcranial direct current stimulation vs sham stimulation to treat aphasia after stroke: a randomized clinical trial. JAMA Neurol 75(12):1470–1476
Billinger SA, Arena R, Bernhardt J, Eng JJ, Franklin BA, Johnson CM, MacKay-Lyons M, Macko RF, Mead GE, Roth EJ, Shaughnessy M, Tang A, American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Lifestyle and Cardiometabolic Health, Council on Epidemiology and Prevention, Council on Clinical Cardiology (2014) Physical activity and exercise recommendations for stroke survivors: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 45(8):2532–2553
Lan C, Lai JS, Chen SY et al (2002) An ancient wisdom on exercise and health promotion. Sports Med 32(4):217–224
van Duijnhoven HJ, Heeren A, Peters MA et al (2016) Effects of exercise therapy on balance capacity in chronic stroke: systematic review and meta-analysis. Stroke. 47(10):2603–2610
Lubetzky-Vilnai A, Kartin D (2010) The effect of balance training on balance performance in individuals poststroke: a systematic review. J Neurol Phys Ther 34(3):127–137
Spalletta G, De Angelis D, Caltagirone C (2000) Poststroke depression and emotional incontinence. Neurology 55(11):1760–1761
Almeida OP, Xiao J (2007) Mortality associated with incident mental health disorders after stroke. Aust N Z J Psychiatry 41(3):274–281
Terry PC, Karageorghis CI, Curran ML, Martin OV, Parsons-Smith RL (2020) Effects of music in exercise and sport: a meta-analytic review. Psychol Bull 146(2):91–117
Terry PC, Karageorghis CI (2006) Psychophysical effects of music in sport and exercise: an updated theory, research, and application (Eds).In: KatsikitisM, ed. Psychology bridging the Tasman: science, culture, and practice. Proceedings of the 2006 Joint Conference of the Australian Psychology Society and the New Zealand Psychological Society. Melboume, VIC. Australian Psychological Society. 415-419
Särkämö T, Ripollés P, Vepsäläinen H et al (2014) Structural changes induced by daily music listening in the recovering brain after middle cerebral artery stroke: a voxel-based morphometry study. Front Hum Neurosci 8:245
Ripollés P, Rojo N, Grau-Sánchez J, Amengual JL, Càmara E, Marco-Pallarés J, Juncadella M, Vaquero L, Rubio F, Duarte E, Garrido C, Altenmüller E, Münte TF, Rodríguez-Fornells A (2016) Music supported therapy promotes motor plasticity in individuals with chronic stroke. Brain Imaging Behav 10(4):1289–1307
Sihvonen AJ, Särkämö T, Leo V, Tervaniemi M, Altenmüller E, Soinila S (2017) Music-based interventions in neurological rehabilitation. Lancet Neurol 16(8):648–660
Salimpoor V, Benovoy M, Larcher K et al (2011) Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nat Neurosci 14:257–262
Särkämö T, Tervaniemi M, Laitinen S et al (2008) Music listening enhances cognitive recovery and mood after middle cerebral artery stroke. Brain. 131(Pt 3):866–876
Leonardi S, Cacciola A, De Luca R et al (2018) The role of music therapy in rehabilitation: improving aphasia and beyond. Int J Neurosci 128(1):90–99
Miller N, Willmes K, De Bleser R (2000) The psychometric properties of the English language version of the Aachen Aphasia Test (EAAT). Aphasiology 14(7):683–722
Gialanella B (2011) Aphasia assessment and functional outcome prediction in patients with aphasia after stroke. J Neurol 258:343–349
Särkämö T, Soto D (2012) Music listening after stroke: beneficial effects and potential neural mechanisms. Ann N Y Acad Sci 1252:266–281
Fotakopoulos G, Kotlia P (2018) The value of exercise rehabilitation program accompanied by experiential music for recovery of cognitive and motor skills in stroke patients. J Stroke Cerebrovasc Dis 27(11):2932–2939
Plowman E, Hentz B, Ellis C Jr (2012) Post-stroke aphasia prognosis: a review of patient-related and stroke-related factors. J Eval Clin Pract 18(3):689–694
Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ(B), Demaerschalk BM, Khatri P, McMullan PW Jr, Qureshi AI, Rosenfield K, Scott PA, Summers DR, Wang DZ, Wintermark M, Yonas H (2013) Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 44:870–947
Muir KW, Baird-Gunning J, Walker L, Baird T, McCormick M, Coutts SB (2007) Can the ischemic penumbra be identified on noncontrast CT of acute stroke? Stroke. 38(9):2485–2490
Campbell BC, Christensen S, Butcher KS, Gordon I, Parsons MW, Desmond PM, Barber PA, Levi CR, Bladin CF, de Silva DA, Donnan GA, Davis SM, EPITHET Investigators (2010) Regional very low cerebral blood volume predicts hemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic stroke. Stroke. 41(1):82–88
Yassi N, Parsons MW, Christensen S, Sharma G, Bivard A, Donnan GA, Levi CR, Desmond PM, Davis SM, Campbell BCV (2013) Prediction of poststroke hemorrhagic transformation using computed tomography perfusion. Stroke. 44(11):3039–3043
Lin L, Bivard A, Parsons MW (2013) Perfusion patterns of ischemic stroke on computed tomography perfusion. J Stroke 15:164–173
Bang OY, Goyal M, Liebeskind DS (2015) Collateral circulation in ischemic stroke: assessment tools and therapeutic strategies. Stroke 46:3302–3309
Ssali T, Anazodo UC, Thiessen JD, Prato FS, St. Lawrence K (2018) A noninvasive method for quantifying cerebral blood flow by hybrid PET/MRI. J Nucl Med 59(8):1329–1334
MacIntosh BJ, Filippini N, Chappell MA et al (2010) Assessment of arterial arrival times derived from multiple inversion time pulsed arterial spin labeling MRI. Magn Reson Med 63(3):641–647
Kunze E, Pham M, Raslan F et al (2012) Value of perfusion CT, transcranial Doppler sonography, and neurological examination to detect delayed vasospasm after aneurysmal subarachnoid hemorrhage. Radiol Res Pract 2012:231206
Cremers CH, van der Schaaf IC, Wensink E et al (2014) CT perfusion and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Cereb Blood Flow Metab 34(2):200–207
Koelsch S (2005) Neural substrates of processing syntax and semantics in music. Curr Opin Neurobiol 15(2):207–212
Ozdemir E, Norton A, Schlaug G (2006) Shared and distinct neural correlates of singing and speaking. Neuroimage 33(2):628–635
Patel AD, Gibson E, Ratner J, Besson M, Holcomb PJ (1998) Processing syntactic relations in language and music: an event-related potential study. J Cogn Neurosci 10(6):717–733
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This study did not receive any external funding. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent was not required. There are no conflicts of interest to declare.
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Aravantinou-Fatorou, K., Fotakopoulos, G. Efficacy of exercise rehabilitation program accompanied by experiential music for recovery of aphasia in single cerebrovascular accidents: a randomized controlled trial. Ir J Med Sci 190, 771–778 (2021). https://doi.org/10.1007/s11845-020-02328-x
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DOI: https://doi.org/10.1007/s11845-020-02328-x