Abstract
Background
Gallbladder stone with symptom is an indication of cholecystectomy according to the current guideline. However, about 80% of gallstone patients are asymptomatic. The identification of gallbladder stone patients likely to develop symptomatic complications would be of benefit in clinical practice.
Aims
The aim of this study was to investigate the risk factors for asymptomatic gallstone diseases developing into a gallstone-related biliary event.
Methods
This retrospective study evaluated 1284 patients with gallstones and received laparoscopic cholecystectomy (LC) in Peking Union Medical College Hospital. The age-gender-matched patients were divided into the acute cholecystitis group (group A), biliary colic group (group B), and asymptomatic gallstone group (group C). Baseline clinical characteristics and serum biochemical indexes were recorded and analyzed among the groups. Univariate logistic regression and multivariate Cox proportional hazard regression analysis were performed to determine the risk factors.
Results
The incidence of diabetes, hypertension, and sludge was higher in group A than in group B and in group C. The concentrations of plasma HDL in group A were lower than those in group B and group C (P < 0.05, 1.12 ± 0.19, vs. 1.21 ± 0.22, vs. 1.21 ± 0.21). Logistic regression analysis showed that diabetes (OR = 1.39, 95% CI 1.07–1.56, P = 0.028), sludge (OR = 1.09, 95% CI 1.01–1.18, P = 0.022), HDL (OR = 0.85, 95% CI 0.70–1.02, P = 0.045), and FBG (1.91, 95% CI 1.26–2.90, P = 0.034) were significantly associated with biliary events.
Conclusions
Diabetes, sludge, and lower blood HDL level are risk factors for symptomatic gallstone diseases.
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Acknowledgments
The authors thank Dr. Benjamin Hafen and Dr. Y Tian for their kind revision of English language. Zhe Cao and Jinghua Wei made equal contributions to this paper.
Funding
The study was supported by the National Key Clinical Specialist Construction Programs of China (2017).
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Cao, Z., Wei, J., Zhang, N. et al. Risk factors of systematic biliary complications in patients with gallbladder stones. Ir J Med Sci 189, 943–947 (2020). https://doi.org/10.1007/s11845-019-02161-x
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DOI: https://doi.org/10.1007/s11845-019-02161-x