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Clinical outcomes of patients with pure small cell carcinoma of the urinary bladder

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Abstract

Objectives

There is not yet a standardized approach to treat patients with small cell carcinoma of the bladder (SmCCB). This study aims to investigate the clinical features, treatment, and survival outcomes of patients with pure SmCCB.

Materials and methods

Patients diagnosed with SmCCB between January 2006 and September 2015 were retrospectively evaluated.

Results

A total of 34 patients with a median age of 63.0 years were included in the study, with a male to female ratio of 4.6:1.0. At the time of diagnosis, 22 patients (64.7%) had stage IV disease. At a median follow-up time of 12.7 months, 67.6% of patients died of bladder carcinoma, with an overall survival (OS) of 15.7 months for all patients. In the patients with stages I–III, nodal involvement, and distant metastases, the median OS was 31.8, 15.7, and 8.4 months, respectively (P = 0.005). Considering the survival rates of the patients (stages I–III) treated with surgery vs. local therapy, there was not a statistically significant difference (26.6 months and 31.8 months, P = 0.97, respectively). A multivariate analysis revealed that stage IV disease and poor ECOG performance status were associated with OS.

Conclusion

The optimal treatment of SmCCB has been under debate. For the patients with advanced stage of disease (T4b, N+, M+), platinum containing chemotherapeutic agents should be preferred. Stage IV disease and poor ECOG performance status were associated with shorter OS.

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Authors and Affiliations

  1. Department of Medical Oncology, Kocaeli Derince Training and Research Hospital, 41310, Kocaeli, Turkey

    Gokmen Umut Erdem

  2. Department of Medical Oncology, Ankara Numune Training and Research Hospital, Ankara, Turkey

    Mutlu Dogan & Nurullah Zengin

  3. Department of Medical Oncology, Medical Faculty of Gazi University, Ankara, Turkey

    Aydin Aytekin

  4. Department of Medical Oncology, Van Training and Research Hospital, Van, Turkey

    Suleyman Sahin

  5. Department of Medical Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey

    Havva Yeşil Cinkir

  6. Department of Medical Oncology, Okmeydani Training and Research Hospital, İstanbul, Turkey

    Abdullah Sakin

  7. Department of Medical Oncology, Kartal Training and Research Hospital, İstanbul, Turkey

    Melike Ozcelik

  8. Department of Medical Oncology, Medical Faculty of Erciyes University, Kayseri, Turkey

    Oktay Bozkurt

  9. Department of Medical Oncology, Medical Faculty of Mersin University, Mersin, Turkey

    Emel Sezer

  10. Department of Medical Oncology, Tekirdag State Hospital, Tekirdag, Turkey

    Nebi Serkan Demirci

  11. Department of Medical Oncology, Edirne State Hospital, Edirne, Turkey

    Yakup Bozkaya

Authors
  1. Gokmen Umut Erdem
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  2. Mutlu Dogan
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  3. Aydin Aytekin
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  9. Emel Sezer
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  11. Yakup Bozkaya
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  12. Nurullah Zengin
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Correspondence to Gokmen Umut Erdem.

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No prospective studies with human participants or animals were performed by any of the authors for this article. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Erdem, G.U., Dogan, M., Aytekin, A. et al. Clinical outcomes of patients with pure small cell carcinoma of the urinary bladder. Ir J Med Sci 189, 431–438 (2020). https://doi.org/10.1007/s11845-019-02074-9

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  • DOI: https://doi.org/10.1007/s11845-019-02074-9

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