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Trans-catheter paravalvular leak closure: a single-centre experience

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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Introduction

A significant paravalvular leak (PVL) is estimated in at least 1–3% of patients undergoing surgical aortic and/or mitral valve replacement. Surgical repair of a PVL is associated with a 30-day mortality of approximately 10%. Percutaneous closure of PVL has emerged as an alternative to surgical repair.

Aim

We sought to examine the clinical outcomes of patients treated with percutaneous closure of PVL at an Irish tertiary referral centre.

Methods

A prospective registry was used to record patient and procedural characteristics at the time of the PVL procedure. Medical records were retrospectively reviewed to assess clinical outcomes during the index hospitalisation and at follow-up.

Results

A total of 26 PVL procedures were performed in 21 patients (mean age 68 ± 13 years, 76% male). Heart failure (HF), haemolysis (HL) or a combination of both was the presenting symptoms in 62%, 24% and 14% of patients, respectively. In the entire cohort, clinical success was achieved in 18 patients (86%). Clinical success was achieved more frequently when HF was the clinical indication compared to HL (100% versus 66%). Among patients presenting with isolated HF (n = 13), the mean NYHA class at baseline and follow-up was 2.5± 0.7 and 1.4± 0.7, respectively. Thirty-day mortality was 0%. There was one (3.8%) major adverse procedural complication (stroke). A total of six deaths (28%) occurred during follow-up (22 ± 13.4 months).

Conclusions

Patients with PVL represent a high-risk patient cohort. Percutaneous PVL offers a safe alternative to surgical PVL repair and appears particularly effective in those patients who present primarily with HF.

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Authors and Affiliations

  1. Department of Cardiology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland

    Richard Tanner, Saber Hassan, Nicola Ryan, Patricia Campbell, Kevin Walsh, Gavin Blake & Ivan P. Casserly

  2. Vancouver General Hospital, Vancouver, Canada

    Saber Hassan

  3. Royal Infirmary, Foresterhill, Aberdeen, Scotland

    Nicola Ryan

  4. Mater Private Hospital, Eccles Street, Dublin 7, Ireland

    Niamh F. Murphy, Ronan Margey, Kevin Walsh, Roger Byrne, Gavin Blake & Ivan P. Casserly

  5. St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland

    Patricia Campbell

Authors
  1. Richard Tanner
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  2. Saber Hassan
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  3. Nicola Ryan
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  4. Niamh F. Murphy
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  5. Patricia Campbell
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  6. Ronan Margey
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  7. Kevin Walsh
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  8. Roger Byrne
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  9. Gavin Blake
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  10. Ivan P. Casserly
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Corresponding author

Correspondence to Ivan P. Casserly.

Ethics declarations

Ethical approval for this study was obtained from the Research Ethics Committee, Mater Misericordiae University Hospital (Ref: 1/378/1881 TMR).

Conflict of interest

The authors declare that they have no conflict of interest.

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Tanner, R., Hassan, S., Ryan, N. et al. Trans-catheter paravalvular leak closure: a single-centre experience. Ir J Med Sci 188, 489–496 (2019). https://doi.org/10.1007/s11845-018-1895-x

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  • DOI: https://doi.org/10.1007/s11845-018-1895-x

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