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An animal model of faecal incontinence and sacral neuromodulation

  • Review Article
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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

The pudendal nerves can be injured during traumatic vaginal childbirth and result in faecal incontinence. Some of these incontinent patients benefit from chronic sacral neuromodulation and the mechanism of action of this therapy has been a focus of many studies. In 2008, a rodent model of neuropathic faecal incontinence was introduced and subsequently validated through a series of investigations. This review summarizes the decade-long contribution of Professor Ronan O’Connell to the inception and application of this rodent model of faecal incontinence and sacral neuromodulation.

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References

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Author information

Authors and Affiliations

  1. Anatomy, School of Medicine, Health Science Centre, University College Dublin, Belfield, Dublin 4, Ireland

    James F. X. Jones

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  1. James F. X. Jones
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Corresponding author

Correspondence to James F. X. Jones.

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Conflict of interest

The author received research funding from the company Medtronic Inc. for some of the studies described in this review.

Ethical approval

All applicable international, national and institutional guidelines for the care and use of animals were followed.

Additional information

Submitted as part of Festschrift for Ronan O’Connell

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Jones, J.F.X. An animal model of faecal incontinence and sacral neuromodulation. Ir J Med Sci 187, 1149–1151 (2018). https://doi.org/10.1007/s11845-018-1805-2

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  • DOI: https://doi.org/10.1007/s11845-018-1805-2

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