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Festschrift for Ronan O’Connell: pouchitis, ulcerative colitis and the microbiome


The hypothesis of altered bacterial communities contributing to the development of pouchitis began a scientific quest to link host mucosal factors, microbial metabolism and spatial structure of the colonic microbiome in ulcerative colitis, reaching its apotheosis with the integration of advanced spatial sampling with laser capture microdissection, mucin array profiling, molecular microbiology and next-generation sequencing technologies. This article, part of a festschrift, summarises the contributions of the O’Connell lab to the field of host-microbial interactions in inflammatory bowel disease.

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  1. Parks AG, Nicholls RJ (1978) Proctocolectomy without ileostomy for ulcerative colitis. Br Med J 2(6130):85–88

    CAS  Article  Google Scholar 

  2. O'Connell PR, Pemberton JH, Kelly KA (1987) Motor function of the ileal J pouch and its relation to clinical outcome after ileal pouch-anal anastomosis. World J Surg 11(6):735–741.

    CAS  Article  PubMed  Google Scholar 

  3. McGuire B, Brannigan A, O’Connell P (2007) Ileal pouch-anal anastomosis. Br J Surg 94(7):812–823

    CAS  Article  Google Scholar 

  4. Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, Talbot IC, Nicholls RJ, Gionchetti P, Campieri M, Kamm MA (2004) Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut 53(1):108–114.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. Ståhlberg D, Gullberg K, Liljeqvist L, Hellers G, Löfberg R (1996) Pouchitis following pelvic pouch operation for ulcerative colitis. Dis Colon Rectum 39(9):1012–1018

    Article  Google Scholar 

  6. Van Assche G, Dignass A, Bokemeyer B et al (2013) Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 3: special situations. J Crohns Colitis 7(1):1–33.

    Article  PubMed  Google Scholar 

  7. O'Connell P, Rankin D, Weiland L et al (1986) Enteric bacteriology, absorption, morphology and emptying after ileal pouch-anal anastomosis. Br J Surg 73(11):909–914

    CAS  Article  Google Scholar 

  8. den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM (2013) The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res 54(9):2325–2340.

    CAS  Article  Google Scholar 

  9. Roediger W (1980) The colonic epithelium in ulcerative colitis: an energy-deficiency disease? Lancet 316(8197):712–715

    Article  Google Scholar 

  10. Duffy MM, Regan MC, Ravichandran P, OʼKeane C, Harrington MG, Fitzpatrick JM, O’Connell PR (1998) Mucosal metabolism in ulcerative colitis and Crohn’s disease. Dis Colon Rectum 41(11):1399–1405.

    CAS  Article  Google Scholar 

  11. Sokol H, Seksik P, Furet J et al (2009) Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis 15(8):1183–1189

    CAS  Article  Google Scholar 

  12. Duffy M, O'Mahony L, Coffey JC et al (2002) Sulfate-reducing bacteria colonize pouches formed for ulcerative colitis but not for familial adenomatous polyposis. Dis Colon Rectum 45(3):384–388

    CAS  Article  Google Scholar 

  13. Gibson GR, Cummings JH, Macfarlane GT (1991) Growth and activities of sulphate-reducing bacteria in gut contents of healthy subjects and patients with ulcerative colitis. FEMS Microbiol Lett (2):103–111

    Article  Google Scholar 

  14. Levine J, Ellis CJ, Furne JK, Springfield J, Levitt MD (1998) Fecal hydrogen sulfide production in ulcerative colitis. Am J Gastroenterol 93(1):83–87

    CAS  Article  Google Scholar 

  15. Coffey JC, Rowan F, Burke J, Dochery N, Kirwan WO, O’Connell PR (2009) Pathogenesis of and unifying hypothesis for idiopathic pouchitis. Am J Gastroenterol 104:1013–1023.

    Article  PubMed  Google Scholar 

  16. Rowan F, Docherty NG, Murphy M, Murphy B, Coffey JC, O’Connell PR (2010) Desulfovibrio bacterial species are increased in ulcerative colitis. Dis Colon Rectum 53(11):1530–1536

    Article  Google Scholar 

  17. Rowan F, Docherty NG, Murphy M, Murphy TB, Coffey JC, OʼConnell PR (2010) Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis. Ann Surg 252(5):869–875

    Article  Google Scholar 

  18. Vandeputte D, Kathagen G, D'Hoe K et al (2017) Quantitative microbiome profiling links gut community variation to microbial load. Nature 7681:507–511.

    CAS  Article  Google Scholar 

  19. Lavelle A, Lennon G, Docherty N, Balfe A, Mulcahy HE, Doherty G, O’Donoghue D, Hyland JM, Shanahan F, Sheahan K, Coffey JC, Winter DC, O’Connell PR (2013) Depth-dependent differences in community structure of the human colonic microbiota in health. PLoS One 8(11):e78835.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  20. Png CW, Linden SK, Gilshenan KS et al (2010) Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. Am J Gastroenterol 105(11):2420–2428.

    CAS  Article  PubMed  Google Scholar 

  21. Hall AB, Yassour M, Sauk J, Garner A, Jiang X, Arthur T, Lagoudas GK, Vatanen T, Fornelos N, Wilson R, Bertha M, Cohen M, Garber J, Khalili H, Gevers D, Ananthakrishnan AN, Kugathasan S, Lander ES, Blainey P, Vlamakis H, Xavier RJ, Huttenhower C (2017) A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients. Genom Med 9(1):103.

    Article  Google Scholar 

  22. Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, LeLeiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C (2012) Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol 13(9):R79.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  23. Lavelle A, Lennon G, O’Sullivan O, Docherty N, Balfe A, Maguire A, Mulcahy HE, Doherty G, O’Donoghue D, Hyland J, Ross RP, Coffey JC, Sheahan K, Cotter PD, Shanahan F, Winter DC, O’Connell PR (2015) Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers. Gut 64(10):1553–1561.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  24. Earley H, Lennon G, Balfe A, Kilcoyne M, Clyne M, Joshi L, Carrington S, Martin ST, Coffey JC, Winter DC, O’Connell PR (2015) A preliminary study examining the binding capacity of Akkermansia muciniphila and Desulfovibrio spp., to colonic mucin in health and ulcerative colitis. PLoS One 10:e0135280.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  25. Whipps J, Lewis K, Cooke R (1988) Mycoparasitism and plant disease control in fungi in biological control systems. Manchester University Press

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Correspondence to Aonghus Lavelle.

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Lavelle, A. Festschrift for Ronan O’Connell: pouchitis, ulcerative colitis and the microbiome. Ir J Med Sci 187, 1133–1137 (2018).

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  • Inflammatory bowel disease
  • Microbiome
  • Pouchitis