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Analysis of sentinel node positivity in primary cutaneous melanoma: an 8-year single institution experience

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Abstract

Background

Sentinel lymph node biopsy (SLNB) is a standard method for determining the pathologic status of the regional lymph nodes.

Aims

The aim of our study was to determine the incidence and clinicopathologic factors predictive of SLN positivity, and to evaluate the prognostic importance of SLNB in patients with cutaneous melanoma.

Methods

We performed a retrospective analysis of a prospectively maintained database of all patients who underwent SLNB for primary melanoma at our institution from 2005 to 2012. Statistical analysis was performed using χ 2 and Fischer exact test.

Results

In total, 318 patients underwent SLNB, of which 65 were for thin melanoma (≤1 mm). There were 36 positive SLNB, 278 negative SLNB and in four cases the SLN was not located. The incidence rate for SLNB was 11.3% overall and 1.5% in thin melanomas alone. Statistical analysis identified Breslow thickness >1 mm (P = 0.006), Clark level ≥ IV (P = 0.004) and age <75 years (P = 0.035) as the strongest predictors of SLN positivity. Our overall false negativity rate was 20% (9/45) with one case of false-negative SLNB in thin melanomas.

Conclusion

Breslow thickness of the primary tumour remains the strongest predictor of SLN positivity. Our findings point to a possible limited role for SLNB in thin melanoma due to its low positivity rate, associated false-negative rate and related morbidity.

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Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, Galway University Hospital, Galway, Ireland

    K. M. Joyce, N. M. McInerney, R. P. Piggott, F. Martin, D. M. Jones, A. J. Hussey, J. L. Kelly & P. J. Regan

  2. Department of Surgery, Clinical Science Institute, Galway University Hospital, Galway, Ireland

    M. J. Kerin

Authors
  1. K. M. Joyce
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  2. N. M. McInerney
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  3. R. P. Piggott
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  4. F. Martin
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  5. D. M. Jones
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  6. A. J. Hussey
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  7. M. J. Kerin
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  8. J. L. Kelly
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  9. P. J. Regan
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Correspondence to K. M. Joyce.

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Joyce, K.M., McInerney, N.M., Piggott, R.P. et al. Analysis of sentinel node positivity in primary cutaneous melanoma: an 8-year single institution experience. Ir J Med Sci 186, 847–853 (2017). https://doi.org/10.1007/s11845-017-1559-2

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  • DOI: https://doi.org/10.1007/s11845-017-1559-2

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