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University Hospital Waterford: 5-year experience of cutaneous melanoma

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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Introduction

The incidence of cutaneous melanoma (CM) continues to rise in Ireland. Despite significant advances in melanoma molecular therapy, surgery remains the mainstay of treatment for CM. The University Hospital Waterford (UHW) prospectively maintained CM registry was established in 2010.

Aim

To summarize 5-year experience (2010–2015) of primary CM presenting to UHW.

Methods

Data were retrospectively obtained from a central electronic pathology and radiology repository augmented by HIPE data and theatre logs. Data collected included patient demographics and clinico-pathological characteristics, specimen number, size, anatomical location, melanoma subtype, Breslow thickness, Clark’s level, ulceration, and mitosis.

Results

592 CMs were managed in UHW during the study period. Overall, females comprised the majority of cases with mean age at presentation 60.78 ± 18.29 years. The most commonly affected anatomical location was the lower limb (26.7%) followed by the back (15.1%), upper limb (15.07%), and face (14.40%). Superficial spreading and lentigo maligna were the most common histological subtype accounting for 19.8 and 20%, respectively. Overall, the mean Breslow depth was 2.4 ± 3.7 mm with corresponding Clark’s Level III. Sentinel lymph node positivity was 39/103 (37.89%) most commonly located in the axilla (53.8%) and groin (30.7%).

Conclusion

There has been a steady increase in the number of cutaneous melanoma presentations over the past 5-years to the South East Cancer Centre. Patients are managed best by prompt surgical excision and multidisciplinary management. Our results are in keeping with international standards and work continues in determining overall 5-year survival and recurrence rates.

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Authors and Affiliations

  1. Department of Breast and Endocrine Surgery, University Hospital Waterford, Waterford, Ireland

    R. Sehgal, C. X. Cheung, R. Alradadi, D. A. Healy, R. Landers & G. T. O’Donoghue

Authors
  1. R. Sehgal
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  2. C. X. Cheung
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  3. R. Alradadi
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  4. D. A. Healy
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  5. R. Landers
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  6. G. T. O’Donoghue
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Corresponding author

Correspondence to R. Sehgal.

Ethics declarations

The melanoma database is enrolled into the University Hospital Waterford clinical audit register since January 2010 and abides to guidelines outlined by the South East Research and Ethics Committee.

Conflict of interest

All authors declare no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Sehgal, R., Cheung, C.X., Alradadi, R. et al. University Hospital Waterford: 5-year experience of cutaneous melanoma. Ir J Med Sci 186, 309–314 (2017). https://doi.org/10.1007/s11845-016-1531-6

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  • DOI: https://doi.org/10.1007/s11845-016-1531-6

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