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Effects of remote ischemic preconditioning on acute myocardial injury in patients undergoing valve replacement

Irish Journal of Medical Science (1971 -) volume 186, pages 889–893 (2017)Cite this article

Abstract

Background

This study investigated the effects of remote ischemic preconditioning (RIPC) on acute myocardial injury and clinical outcome in adult patients undergoing valve replacement surgery.

Methods

Sixty-three adult patients scheduled for elective valve replacement undergoing cardiopulmonary bypass (CPB) were randomly assigned to control or remote ischemic preconditioning treatment. RIPC was applied beginning with the first surgical incision by three times of inflating the cuff to 200 mmHg for 5 min, followed by 5 min of deflation. The plasma creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) were determined. The preoperative, intraoperative, and postoperative characteristics, and hemodynamics values were recorded during the study.

Results

There were no significant differences in patient preoperative, intraoperative, and postoperative characteristics and hemodynamics values between groups. The activity of CK-MB and cTnI was significantly lower in RIPC group than CON group at 4 and 48 h after aortic unclamping.

Conclusions

The present study demonstrated that remote ischemic preconditioning might reduce release of CK-MB and cTnI in patients undergoing valve replacement. However, RIPC does not improve the clinical outcome of these patients.

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Affiliations

  1. Department of Cardiac Surgery, Affiliated Province Hospital of Anhui Medical University, Hefei, 230001, China

    Z. Cao, R. Shen, X. Zhang, G. Cheng & Z. Yan

Authors
  1. Z. Cao
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  2. R. Shen
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  3. X. Zhang
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  4. G. Cheng
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  5. Z. Yan
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Corresponding author

Correspondence to Z. Yan.

Ethics declarations

This study was supported by health commission of Anhui province of China (09A006). The institutional review board of the Affiliated Province Hospital of Anhui Medical University approved this study, and all procedures performed in this study were in accordance with the ethical standards of our institution.

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Written informed consent was obtained from all patients.

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Cao, Z., Shen, R., Zhang, X. et al. Effects of remote ischemic preconditioning on acute myocardial injury in patients undergoing valve replacement. Ir J Med Sci 186, 889–893 (2017). https://doi.org/10.1007/s11845-016-1521-8

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  • DOI: https://doi.org/10.1007/s11845-016-1521-8

Keywords

  • Remote ischemic preconditioning
  • Myocardial
  • Ischemia–reperfusion injury
  • Valve