Proposed differences in caffeine metabolism due to the CYP1A2*1F polymorphism have been linked to variations in cardiovascular disease risk.
We examined the influence of a CYP1A2*1F polymorphism on post-exercise heart rate variability (HRV) in response to caffeine intake.
Volunteers were identified as A/A homozygotes (A/A; 4 females and 7 males; age: 25.3 ± 4.1 years; BMI: 25.9 ± 4.4 kg/m2) or C allele carriers (C allele; 3 females and 6 males; age: 25.5 ± 2.8 years; BMI: 26.6 ± 5.0 kg/m2) for participation in a repeated measures, counterbalanced, double-blind, placebo-controlled trial. Participants chewed three pieces of gum containing either caffeine (CAF) (100 mg/piece) or placebo for 5 min. Thereafter, participants cycled for 15 min at 75 % of their peak oxygen consumption. Eight HRV indices computed during 5 min at baseline (BASE), 0–5 min after exercise (POST1), and 5–10 min after exercise (POST2) were used for analysis.
No significant group differences were detected in HRV indices at BASE, POST1, or POST2 during both trials (p > 0.05). Rate of recovery (POST2–POST1) for the square root of the mean of squared differences between successive RR intervals (RMSSD) was significantly different between A/A (6.0 ± 2.5 ms) and C allele (3.6 ± 2.5 ms) groups during the CAF trial (p = 0.048).
Rate of RMSSD recovery was the only variable influenced by the CYP1A2*IF polymorphism during post-exercise in response to caffeine intake. Thus, the CYP1A2*1F polymorphism did not overtly influence the effects of caffeine intake on post-exercise HRV.
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This work was conducted at Chatham University in Pittsburgh, PA, USA. Support for this research was provided by the Research and Sabbatical Committee at Chatham University, and the Departments of Biology and Exercise Science at Chatham University.
Conflict of interest
The authors declare no conflict of interest in relation to this study.
Research involving human participants and/or animals
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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Thomas, R.M., Algrain, H.A., Ryan, E.J. et al. Influence of a CYP1A2 polymorphism on post-exercise heart rate variability in response to caffeine intake: a double-blind, placebo-controlled trial. Ir J Med Sci 186, 285–291 (2017). https://doi.org/10.1007/s11845-016-1478-7