Abstract
Background
Recent developments in the management of severe aortic stenosis have resulted in a paradigm shift in the way we view the condition. Patients previously denied intervention in the form of surgical aortic valve replacement (SAVR) are now candidates for transcatheter aortic valve implantation and the risk and age profiles of those undergoing SAVR are rising with the ageing population. This review article is designed to provide an overview of developments in the surgical management of severe aortic stenosis. We also discuss the expanding role of minimally invasive surgical approaches to outline the current techniques available to treat patients with severe aortic stenosis.
Methods
PubMed was searched using the terms ‘severe aortic stenosis’, ‘surgical aortic valve replacement’, ‘transcatheter aortic valve replacement’, ‘mechanical aortic valve replacement’ and ‘sutureless aortic valve replacement’. Selection of articles was based on peer review, journal and relevance. Where possible articles from high-impact factor peer review journals were included.
Results
Minimally invasive operative approaches include mini-sternotomy and mini-thoracotomy. Sutureless aortic prostheses reduce aortic cross-clamp time and cardiopulmonary bypass time; however, long-term follow-up data are unavailable at this time. Mechanical prostheses are advised for those under 60.
Conclusion
Multiple advances in the surgical management of aortic stenosis have occured in the past decade. An evolving spectrum of surgical and transcatheter interventions is now available depending on patient age and operative risk.
Similar content being viewed by others
References
Christensen K, Doblhammer G, Rau R, Vaupel JW (2009) Ageing populations: the challenges ahead. Lancet 374(9696):1196–1208
Jagger C, McKee M, Christensen K, Lagiewka K, Nusselder W, Van Oyen H et al (2013) Mind the gap—reaching the European target of a 2-year increase in healthy life years in the next decade. Eur J Pub Health 23(5):829–833
Thaden JJ, Nkomo VT, Enriquez-Sarano M (2014) The global burden of aortic stenosis. Prog Cardiovasc Dis 56(6):565–571
Horstkotte D, Loogen F (1998) The natural history of aortic valve stenosis. Eur Heart J 9(Suppl E):57–64
Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M (2006) Burden of valvular heart diseases: a population-based study. Lancet 368(9540):1005–1011
Rayner J, Coffey S, Newton J, Prendergast BD (2014) Aortic valve disease. Int J Clin Pract 68(10):1209–1215
Barreto-Filho JA, Wang Y, Dodson JA, Desai MM, Sugeng L, Geirsson A et al (2013) Trends in aortic valve replacement for elderly patients in the United States, 1999–2011. J Am Med Assoc (JAMA) 310(19):2078–2085
Cribier A (2012) Development of transcatheter aortic valve implantation (TAVI): a 20-year odyssey. Arch Cardiovasc Dis 105(3):146–152
Cribier A, Eltchaninoff H, Bash A, Borenstein N, Tron C, Bauer F et al (2002) Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description. Circulation 106(24):3006–3008
Seiffert M, Sinning JM, Meyer A, Wilde S, Conradi L, Vasa-Nicotera M et al (2014) Development of a risk score for outcome after transcatheter aortic valve implantation. Clin Res Cardiol 103(8):631–640
Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA et al (2014) 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 129(23):2440–2492
Brown JM, O’Brien SM, Wu C, Sikora JA, Griffith BP, Gammie JS (2009) Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database. J Thorac Cardiovasc Surg 137(1):82–90
Borger MA, Nette AF, Maganti M, Feindel CM (2007) Carpentier-Edwards Perimount Magna valve versus Medtronic Hancock II: a matched hemodynamic comparison. Ann Thorac Surg 83(6):2054–2058
Asch FM, Heimansohn D, Doyle D, Dembitsky W, Ferdinand FD, Swanson J et al (2012) Mitroflow aortic bioprosthesis 5-year follow-up: north american prospective multicenter study. Ann Thorac Surg 94(4):1198–1203
Investigators I (2011) The Italian study on the Mitroflow postoperative results (ISTHMUS): a 20-year, multicentre evaluation of Mitroflow pericardial bioprosthesis. Eur J Cardiothorac Surg 39(1):18–26 (discussion)
Bavaria JE, Desai ND, Cheung A, Petracek MR, Groh MA, Borger MA et al (2014) The St Jude Medical Trifecta aortic pericardial valve: results from a global, multicenter, prospective clinical study. J Thorac Cardiovasc Surg 147(2):590–597
Jamieson WR, Lewis CT, Sakwa MP, Cooley DA, Kshettry VR, Jones KW et al (2011) St Jude Medical Epic porcine bioprosthesis: results of the regulatory evaluation. J Thorac Cardiovasc Surg 141(6):1449–1454.e2
Akins CW (1995) Results with mechanical cardiac valvular prostheses. Ann Thorac Surg 60(6):1836–1844
Kaneko T, Aranki SF (2013) Anticoagulation for prosthetic valves. Thrombosis 2013:346752
Puskas J, Gerdisch M, Nichols D, Quinn R, Anderson C, Rhenman B et al (2014) Reduced anticoagulation after mechanical aortic valve replacement: interim results from the prospective randomized on-X valve anticoagulation clinical trial randomized Food and Drug Administration investigational device exemption trial. J Thorac Cardiovasc Surg 147(4):1202–1210 (discussion 10-1)
Chan V, Jamieson WR, Lam BK, Ruel M, Ling H, Fradet G et al (2010) Influence of the On-X mechanical prosthesis on intermediate-term major thromboembolism and hemorrhage: a prospective multicenter study. J Thorac Cardiovasc Surg 140(5):1053–1058.e2
Chambers JB, Pomar JL, Mestres CA, Palatianos GM (2013) Clinical event rates with the On-X bileaflet mechanical heart valve: a multicenter experience with follow-up to 12 years. J Thorac Cardiovasc Surg 145(2):420–424
Yezbick AB, Ho JK, Crowley R, Sanchez E, Mahajan A (2008) Echocardiographic signature of the On-X valve. Echocardiography 25(9):1016–1018
Weber A, Noureddine H, Englberger L, Dick F, Gahl B, Aymard T et al (2012) Ten-year comparison of pericardial tissue valves versus mechanical prostheses for aortic valve replacement in patients younger than 60 years of age. J Thorac Cardiovasc Surg 144(5):1075–1083
Magovern GJ, Cromie HW (1963) Sutureless prosthetic heart valves. J Thorac Cardiovasc Surg 46:726–736
Magovern GJ, Liebler GA, Cushing WJ, Park SB, Burkholder JA (1977) A thirteen-year review of the Magovern-Cromie aortic valve. J Thorac Cardiovasc Surg 73(1):64–74
Wendt D, Thielmann M, Pizanis N, Janosi RA, Kamler M, Jakob H (2009) Sutureless aortic valves over the last 45 years. Minim Invasive Therapy Allied Technol (MITAT) 18(3):122–130
Magovern GJ, Liebler GA, Park SB, Burkholder JA, Sakert T, Simpson KA (1989) Twenty-five-year review of the Magovern-Cromie sutureless aortic valve. Ann Thorac Surg 48(3 Suppl):S33–S34
D’Onofrio A, Messina A, Lorusso R, Alfieri OR, Fusari M, Rubino P et al (2012) Sutureless aortic valve replacement as an alternative treatment for patients belonging to the “gray zone” between transcatheter aortic valve implantation and conventional surgery: a propensity-matched, multicenter analysis. J Thorac Cardiovasc Surg 144(5):1010–1016
Santarpino G, Fischlein T (2014) Use of sutureless prosthetic aortic valves in cardiac surgery. G Ital Cardiol 15(3):170–176
Chalmers J, Pullan M, Mediratta N, Poullis M (2014) A need for speed?. Bypass time and outcomes after isolated aortic valve replacement surgery, Interact Cardiovasc Thorac Surg
Shrestha M, Maeding I, Hoffler K, Koigeldiyev N, Marsch G, Siemeni T et al (2013) Aortic valve replacement in geriatric patients with small aortic roots: are sutureless valves the future? Interact Cardiovasc Thorac Surg 17(5):778–782 (discussion 82)
Pollari F, Santarpino G, Dell’Aquila AM, Gazdag L, Alnahas H, Vogt F et al (2014) Better short-term outcome by using sutureless valves: a propensity-matched score analysis. Ann Thorac Surg 98(2):611–616 (discussion 6–7)
Concistre G, Miceli A, Chiaramonti F, Glauber M (2012) Delayed dislocation of a sutureless aortic bioprosthesis: the first case. Interact Cardiovasc Thorac Surg 14(6):892–893
Paredes FA, Canovas SJ, Gil O, Garcia-Fuster R, Hornero F, Vazquez A et al (2013) Minimally invasive aortic valve surgery. a safe and useful technique beyond the cosmetic benefits. Rev Esp Cardiol 66(9):695–699
Ceresa F, Sansone F, Patane F (2012) Aortic valve replacement through the upper ministernotomy: preliminary experience with modified technique. G Chir 33(10):311–313
Olin CL, Peterffy A (1995) Minimal access aortic valve surgery. Eur J Cardio-thorac Surg 15(Suppl 1):S32–S38 (discussion S9-43)
Chang YS, Lin PJ, Chang CH, Chu JJ, Tan PP (1999) “I” ministernotomy for aortic valve replacement. Ann Thorac Surg 68(1):40–45
Aris A, Camara ML, Montiel J, Delgado LJ, Galan J, Litvan H (1999) Ministernotomy versus median sternotomy for aortic valve replacement: a prospective, randomized study. Ann Thorac Surg 67(6):1583–1587 (discussion 7-8)
Bonacchi M, Prifti E, Giunti G, Frati G, Sani G (2002) Does ministernotomy improve postoperative outcome in aortic valve operation? A prospective randomized study. Ann Thorac Surg 73(2):460–465 (discussion 5-6)
Mihaljevic T, Cohn LH, Unic D, Aranki SF, Couper GS, Byrne JG (2004) One thousand minimally invasive valve operations: early and late results. Ann Surgery 240(3):529–534 (discussion 34)
Doll N, Borger MA, Hain J, Bucerius J, Walther T, Gummert JF et al (2002) Minimal access aortic valve replacement: effects on morbidity and resource utilization. Ann Thorac Surg 74(4):S1318–S1322
Dooley A, Asimakopoulos G (2013) Does a minimally invasive approach result in better pulmonary function postoperatively when compared with median sternotomy for coronary artery bypass graft? Interact Cardiovasc Thorac Surg 16(6):880–885
Elhmidi Y, Bleiziffer S, Piazza N, Voss B, Krane M, Deutsch MA et al (2013) Long-term results after transcatheter aortic valve implantation: what do we know today? Curr Cardiol Rev 9(4):295–298
Conradi L, Seiffert M, Schirmer J, Koschyk D, Blankenberg S, Reichenspurner H et al (2014) Transapical transcatheter aortic valve implantation without prior balloon aortic valvuloplasty: feasible and safedagger. Eur J Cardiothorac Surg 46(1):61–66
Laflamme M, Mazine A, Demers P, Lamarche Y, Ibrahim R, Asgar A et al (2014) Transcatheter aortic valve implantation by the left axillary approach: a single-center experience. Ann Thorac Surg 97(5):1549–1554
Dahle G, Rein KA (2014) Direct aorta ascending approach in transcatheter aortic valve implantation. Innovations 9(1):1–9
Azmoun A, Amabile N, Ramadan R, Ghostine S, Caussin C, Fradi S et al (2014) Transcatheter aortic valve implantation through carotid artery access under local anaesthesia. Eur J Cardiothorac Surg 46(4):693–698 (discussion 8)
Bleiziffer S, Krane M, Deutsch MA, Elhmidi Y, Piazza N, Voss B et al (2013) Which way in? The necessity of multiple approaches to transcatheter valve therapy. Curr Cardiol Rev 9(4):268–273
Holmes DR Jr, Mack MJ, Kaul S, Agnihotri A, Alexander KP, Bailey SR et al (2012) 2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aortic valve replacement. J Am Coll Cardiol 59(13):1200–1254
Cribier A (2012) Development of transcatheter aortic valve implantation (TAVI): a 20-year odyssey. Arch Cardiovasc Dis 105(3):146–152
TAVIinformation.com 2011. http://taviinformation.com
Vahanian A (2001) Balloon valvuloplasty. Heart 85(2):223–228
Aksoy O, O’Brien BL, Menon V (2013) Options for managing severe aortic stenosis: a case-based review. Clevel Clin J Med 80(4):243–252
Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG et al (2010) Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 363(17):1597–1607
Neragi-Miandoab S, Skripochnik E, Salemi A, Girardi L (2013) Recently patented transcatheter aortic valves in clinical trials. Recent Pat Cardiovasc Drug Discov 8(3):186–191
O’Sullivan KE, Gough A, Segurado R, Barry M, Sugrue D, Hurley J (2014) Is valve choice a significant determinant of paravalular leak post-transcatheter aortic valve implantation? A systematic review and meta-analysis. Eur J Cardiothorac Surg 45(5):826–833
Eggebrecht H, Schmermund A, Voigtlander T, Kahlert P, Erbel R, Mehta RH (2012) Risk of stroke after transcatheter aortic valve implantation (TAVI): a meta-analysis of 10,037 published patients. EuroIntervention 8(1):129–138
Aggarwal S, Reinthaler M, Cheang MH, Mullen M (2014) 104 transcranial Doppler-detected emboli can be differentiated between solid and gaseous emboli during transcatheter aortic valve implantation and this has implications for neuroprotective strategies. Heart 100(Suppl 3):A60
Onsea K, Agostoni P, Samim M, Voskuil M, Kluin J, Budde R et al (2012) First-in-man experience with a new embolic deflection device in transcatheter aortic valve interventions. EuroIntervention 8(1):51–56
KE OS, Casserly I, Hurley J (2014) Transapical JenaValve in a patient with mechanical mitral valve prosthesis. Catheter Cardiovasc Interv 85(5):916–919
O’Sullivan KE, Early SA, Casserly I, Chugtai Z, Sugrue D, Hurley J (2014) Experience of a high-risk aortic valve clinic in Ireland. Ir J Med Sci 183(4):653–657
Showkathali R, Chelliah R, Brickham B, Dworakowski R, Alcock E, Deshpande R et al (2014) Multi-disciplinary clinic: next step in “Heart team” approach for TAVI. Int J Cardiol 174(2):453–455
Vahanian A, Himbert D, Brochet E, Depoix JP, Iung B, Nataf P (2012) Transcatheter aortic valve implantation: our vision of the future. Arch Cardiovasc Dis 105(3):181–186
Kocher AA, Laufer G, Haverich A, Shrestha M, Walther T, Misfeld M et al (2013) One-year outcomes of the Surgical Treatment of Aortic Stenosis With a Next Generation Surgical Aortic Valve (TRITON) trial: a prospective multicenter study of rapid-deployment aortic valve replacement with the EDWARDS INTUITY Valve System. J Thorac Cardiovasc Surg 145(1):110–115 (discussion 5-6)
Miceli A, Santarpino G, Pfeiffer S, Murzi M, Gilmanov D, Concistre G et al (2014) Minimally invasive aortic valve replacement with perceval S sutureless valve: early outcomes and one-year survival from two European centers. J Thorac Cardiovasc Surg 148(6):2838–2843
Rubino AS, Santarpino G, De Praetere H, Kasama K, Dalen M, Sartipy U et al (2014) Early and intermediate outcome after aortic valve replacement with a sutureless bioprosthesis: Results of a multicenter study. J Thorac Cardiovasc Surg 148(3):865–871 (discussion 71)
Martens S, Sadowski J, Eckstein FS, Bartus K, Kapelak B, Sievers HH et al (2011) Clinical experience with the ATS 3f Enable(R) Sutureless Bioprosthesis. Eur J Cardiothorac Surg 40(3):749–755
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors have no conflict of interest to declare.
Rights and permissions
About this article
Cite this article
O’Sullivan, K.E., Bargenda, S., Sugrue, D. et al. Advances in the management of severe aortic stenosis. Ir J Med Sci 185, 309–317 (2016). https://doi.org/10.1007/s11845-016-1417-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11845-016-1417-7