Skip to main content

Investigation of cardiovascular disease risk in women with uterine leiomyomas



The aim of this study was to investigate the cardiovascular disease risk of patients with uterine leiomyoma using carotid intima-media thickness (CIMT), insulin resistance and lipid profile.


A total of 84 reproductive-aged women (20–45 years) were divided into two groups as the study group (n = 42) of women with leiomyoma and the control group (n = 42) of healthy women without leiomyoma. The risk factors for cardiovascular disease such as age, body mass index (BMI), low-density lipoprotein (LDL), triglycerides (Tg), high-density lipoprotein (HDL), total cholesterol and lipoprotein a levels, systemic disorders, cigarette smoking and CIMT were all recorded and compared between groups.


The mean age, gravida, parity, BMI, total cholesterol level and CIMT were significantly different between the groups (p < 0.05). CIMT after adjusted for the age and age, BMI was significantly lower in study groups (<0.001). Insulin resistance, serum LDL, Tg, HDL, lipoprotein a, and endometrial thickness were comparable between groups (p > 0.05). The number of leiomyoma was significantly correlated with Tg (r = 0. 322, p = 0.037) and LDL (r = 0. 431, p = 0.006). The size of leiomyoma was significantly correlated with HOMA-IR values (r = −0.370, p = 0.016).


Uterine leiomyoma was associated with lipid profile, insulin resistance and CIMT in reproductive-aged women.

This is a preview of subscription content, access via your institution.

Fig. 1


  1. Vollenhoven BJ, Lawrence AS, Healy DL (1997) Uterin fibroids. Br J Obstet Gynaecol 97:285–298

    Article  Google Scholar 

  2. Stewart EA, Nowak RA (1998) New concepts in the treatment of uterine leiomyomas. Obstet Gynecol 92:624

    CAS  PubMed  Google Scholar 

  3. Faerstein E, Szklo M, Rosenshein NB (2001) Risk factors for uterine leiomyoma: a practice-based case-control study. II. Atherogenic risk factors and potential sources of uterine irritation. Am J Epidemiol 153:11

    Article  CAS  PubMed  Google Scholar 

  4. Izumi S, Muano T, Mori A, Kika G, Okuwaki S (2006) Common carotid artery stiffness, cardiovascular function and lipid metabolism after menopause. Life Sci 78(15):1696–1701

    Article  CAS  PubMed  Google Scholar 

  5. Prati P, Tosetto A, Vanuzzo D, Bader G, Casaroli M, Canciani L, Castellani S, Touboul PJ (2008) Carotid intima media thickness and plaques can predict the occurrence of ischemic cerebrovascular events. Stroke 39:2470–2476

    Article  PubMed  Google Scholar 

  6. Knopfholz J, Disserol CC, Pierin AJ, Schirr FL, Streisky L, Takito LL, Massucheto Ledesma P, Faria-Neto JR, Olandoski M, da Cunha CL, Bandeira AM (2014) Validation of the friedewald formula in patients with metabolic syndrome. Cholesterol 2014:261878

  7. Mogul HR, Freeman R, Nguyen K, Frey M, Klein LA, Jozak S, Tanenbaum K (2014) Carbohydrate modified diet & insulin sensitizers reduce body weight and modulate metabolic syndrome measures in EMPOWIR (enhance the metabolic profile of women with insulin resistance): a randomized trial of normoglycemic women with midlife weight gain. PLoS One 9(9):e108264

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kallen AN, Pal L (2011) Cardiovascular disease and ovarian function. Curr Opin Obstet Gynecol 23(4):258–267

    Article  PubMed  Google Scholar 

  9. Karim R, Hodis HN, Stanczyk FZ, Lobo RA, Mack WJ (2008) Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women. J Clin Endocrinol Metab 93(1):131–138

    Article  CAS  PubMed  Google Scholar 

  10. Kłosiewicz-Wasek B, Ceremuzyński L, Poloński L, Lukaszewicz R, Wasilewski J (2008) Association between carotid artery atherosclerosis and coronary artery disease in young females. Reference to sex hormone profile. Kardiol Pol 66(2):127–132 (discussion 133–134)

  11. Aksoy Y, Sivri N, Karaoz B, Sayin C, Yetkin E (2014) Carotid intima-media thickness: a new marker of patients with uterine leiomyoma. Eur J Obstet Gynecol Reprod Biol 175:54–57

  12. Jauhiainen M, Koskinen P, Enholm C et al (1991) Lipoprotein(a)and coronary heart disease risk. A nested case-control study of the Helsinki Heart Study Participants. Atherosclerosis 89:59–67

    Article  CAS  PubMed  Google Scholar 

  13. Danesh J, Collins R, Peto R (2000) Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation 102:1082–1085

    Article  CAS  PubMed  Google Scholar 

  14. Hong SJ, Seo HS, Park CG, Rha SW, Oh DJ, Ro YM (2005) Serially increasing change in lipoprotein(a) concentration has predictive value in acute vascular events. Ann Clin Biochem 42(Pt4):285–291

    Article  CAS  PubMed  Google Scholar 

  15. Sadlonova J, Kostal M, Smahelova A, Hendl J, Starkova J, Nachtigal P (2008) Selected metabolic parameters and the risk for uterine fibroids. Int J Gynaecol Obstet 102(1):50–54

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to V. Korkmaz.

Ethics declarations

Conflict of interest

The authors report no conflicts of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Korkmaz, V., Ozkaya, E., Özer Kadife, S. et al. Investigation of cardiovascular disease risk in women with uterine leiomyomas. Ir J Med Sci 185, 689–693 (2016).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • Uterine leiomyomas
  • Carotid intima-media thickness
  • Cardiovascular disease risk