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The effect of Glutathione-S-transferases in the susceptibility to bladder cancer

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Abstract

Background

Urinary bladder cancer is a quite common cancer type in men and women all over the world. Genetic polymorphisms of xenobiotic-metabolizing enzymes could increase individual susceptibility to various cancer types.

Aims

The aim of our study is to evaluate the rate of these polymorphisms in a group of patients from Central Anatolia.

Methods

Our study subjects consist of 65 men with histopathologically confirmed bladder TCC and 70 cancer-free control subjects. Restriction fragment length polymorphism (RFLP) method was used for the detection of polymorphisms of GSTT1 and GSTM1.

Results

There was no association between bladder cancer and GSTM1 polymorphism (ORs = 0.64, 95 % CI = 0.32–1.29), but the probability of bladder cancer in patients with GSTT1 null genotype (67.9 %), was significantly higher from the probability of bladder cancer with GSTT1 normal genotype (43.0 %) statistically (ORs = 2.8, 95 % CI = 1.16–6.75).

Conclusion

Polymorphisms of these genes have been assessed to evaluate the relative risk of various cancers. Our intention is to continue this study with larger series of bladder cancer patients in a group of Turkish population from Central Anatolia.

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References

  1. Ferlay J, Bray F, Pisani P, Parkin DM, GLOBOCAN (2002) Cancer incidence, mortality and prevalence worldwide. IARC cancer base no. 5, version 1.0. International agency for research on cancer

  2. Konety BR, Williams RD (2004) Superficial transitional (Ta/T1/CIS) cell carcinoma of the bladder. BJU Int 94:18–21

    Article  PubMed  Google Scholar 

  3. Jemal A, Thomas A, Murray T, Thun M (2002) Cancer statistics 2002. CA Cancer J Clin 52:23–47

    Article  PubMed  Google Scholar 

  4. Heney NM (1992) Natural history of superficial bladder cancer. Prognostic features and long-term disease course. Urol Clin NorthAm 19:429–433

    CAS  Google Scholar 

  5. Cohen SM, Shirai T, Steineck G (2000) Epidemiology and etiology of premalignant and malignant urothelial changes. Scand J Urol Nephrol (Suppl) 205:105–115

    Article  Google Scholar 

  6. Stern MC, Johnson LR, Bell DA, Taylor JA (2000) XPD Codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev 11:1004–1011

    Google Scholar 

  7. Sanyal S, Festa F, Sakano S et al (2004) Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis 25:729–734

    Article  CAS  PubMed  Google Scholar 

  8. Safarinejad MR, Shafiei N, Safarinejad S (2010) The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility. J Hum Genet 55:565–570

    Article  CAS  PubMed  Google Scholar 

  9. Karagas MR, Park S, Warren A, Hamilton J, Nelson HH, Mott LA, Kelsey KT (2005) Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Lett 219:63–69

    Article  CAS  PubMed  Google Scholar 

  10. Srivastava DS, Kumar A, Mittal B, Mittal RD (2004) Polymorphism of GSTM1 and GSTT1 genes in bladder cancer: a study from North India. Arch Toxicol 78:430–434

    Article  CAS  PubMed  Google Scholar 

  11. Shao J, Gu M, Zhang Z, Xu Z, Hu Q, Qian L (2008) Genetic variants of the cytochrome P450 and glutathione S-transferase associated with risk of bladder cancer in a south-eastern Chinese population. Int J Urol 15:216–221

    Article  CAS  PubMed  Google Scholar 

  12. Sobti RC, Al-Badran AI, Sharma S, Sharma SK, Krishan A, Mohan H (2005) Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India. Cancer Genet Cytogenet 156:68–73

    Article  CAS  PubMed  Google Scholar 

  13. McGrath M, Michaud D, De Vivo I (2006) Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women. BMC Cancer 6:239

    Article  PubMed Central  PubMed  Google Scholar 

  14. Salagovic J, Kalina I, Stubna J, Habalová V, Hrivnák M, Valanský L, Kohút A, Biros E (1998) Genetic polymorphism of glutathione S-transferase M1 and T1 and risk factor in lung and bladder cancer. Neoplasma 45:312–317

    CAS  PubMed  Google Scholar 

  15. Singh M, Shah PP, Singh AP, Ruwali M, Mathur N, Pant MC, Parmar D (2008) Association of genetic polymorphisms in glutathione S-transferases and susceptibility to head and neck cancer. Mutat Res 638:184–194

    Article  CAS  PubMed  Google Scholar 

  16. Smits KM, Gaspari L, Weijenberg MP et al (2003) Interaction between smoking, GSTM1 deletion, and colorectal cancer: results from the GSEC study. Biomarkers 8:299–310

    Article  CAS  PubMed  Google Scholar 

  17. Lee SJ, Cho SH, Park SK et al (2002) Combined effect of glutathione S-transferase M1 and T1 genotypes on bladder cancer risk. Cancer Lett 28(177):173–179

    Article  Google Scholar 

  18. Steinhoff C, Franke KH, Golka K, Thier R, Römer HC, Rötzel C, Ackermann R, Schulz WA (2000) Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma. Arch Toxicol 74:521–526

    Article  CAS  PubMed  Google Scholar 

  19. Abdel-Rahman SZ, Anwar WA, Abdel-Aal WE, Mostafa HM, Au WW (1998) GSTM1 and GSTT1 genes are potential risk modifiers for bladder cancer. Cancer Detect Prev 22:129–138

    Article  CAS  PubMed  Google Scholar 

  20. Zeng FF, Liu SY, Wei W et al (2010) Genetic polymorphisms of glutathione S-transferase T1 and bladder cancer risk: a meta-analysis. Clin Exp Med. 10:59–68

    Article  CAS  PubMed  Google Scholar 

  21. Franekova M, Halasova E, Bukovska E, Luptak J, Dobrota D (2008) Gene polymorphisms in bladder cancer. Urol Oncol 26(1):1–8

    Article  CAS  PubMed  Google Scholar 

  22. Katoh T, Inatomi H, Kim H, Yang M, Matsumoto T, Kawamoto T (1998) Effects of glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelial cancer risk. Cancer Lett 132:147–152

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Medical Genetics, Yildirim Beyazit University, Ankara, Turkey

    G. G. Ceylan

  2. Urology Clinics, Türkiye Yüksek İhtisas Education and Training Hospital, Ankara, Turkey

    C. Ceylan & S. Taşdemir

  3. Microbiology, Ankara Atatürk Education and Training Hospital, Ankara, Turkey

    A. Gözalan

Authors
  1. G. G. Ceylan
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  2. C. Ceylan
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  3. S. Taşdemir
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  4. A. Gözalan
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Correspondence to G. G. Ceylan.

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Ceylan, G.G., Ceylan, C., Taşdemir, S. et al. The effect of Glutathione-S-transferases in the susceptibility to bladder cancer. Ir J Med Sci 184, 851–854 (2015). https://doi.org/10.1007/s11845-014-1200-6

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  • DOI: https://doi.org/10.1007/s11845-014-1200-6

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