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α1-Blockers in the management of acute urinary retention secondary to benign prostatic hyperplasia: a systematic review and meta-analysis

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Abstract

Background

α1-Blockers have been widely used in the conservative management of acute urinary retention (AUR).

Aims

To compare the efficacy and safety of α1-blockers in male patients with AUR secondary to benign prostatic hyperplasia (BPH).

Methods

Electronic searches on PubMed/MEDLINE, EMBASE and the Cochrane Library were performed to identify all published randomized controlled trials (RCTs) and controlled clinical trials (CCTs) of α1-blockers for the treatment of AUR. Relevant reviews and reference lists of included studies were explored.

Results

Nine studies involving a total of 1051 men were enrolled in this review. Compared to 38.9 % (161/414) in control groups, 56.8 % (362/637) of patients receiving α1-blockers had a successful trial without catheter (TWOC). Meta-analysis demonstrated that α1-blockers have a substantial effect on the successful resumption of micturition after TWOC (RR = 1.45, 95 % CI 1.20–1.75, P = 0.0001). In the subsequent phase, the outcomes across studies indicated that α1-blockers may provide little benefit to maintain the satisfactory voiding without AUR recurrence or BPH surgery in a long-term follow-up. α1-Blockers were generally low and well tolerated in both phases.

Conclusions

In conclusion, α1-blockers provide substantial benefit in increasing a satisfactory micturition within 24 h after TWOC for men with AUR due to BPH, even though the long-term effectiveness remains uncertain.

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None of the authors have any conflict of interest.

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Authors and Affiliations

  1. Minimally Invasive Urology Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China

    D. Guang-Jun, G. Feng-Bin & J. Xun-Bo

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  1. D. Guang-Jun
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  2. G. Feng-Bin
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  3. J. Xun-Bo
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Correspondence to J. Xun-Bo.

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Guang-Jun, D., Feng-Bin, G. & Xun-Bo, J. α1-Blockers in the management of acute urinary retention secondary to benign prostatic hyperplasia: a systematic review and meta-analysis. Ir J Med Sci 184, 23–30 (2015). https://doi.org/10.1007/s11845-014-1094-3

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  • DOI: https://doi.org/10.1007/s11845-014-1094-3

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