Advertisement

Irish Journal of Medical Science

, Volume 183, Issue 2, pp 297–301 | Cite as

Modest correlation between serum neopterin levels and Gensini scores in a cohort of patients undergoing coronary angiography

  • C. ÖzbekEmail author
  • İ. Baran
  • A. Tütüncü
  • T. Kuştarcı
  • K. Karaağaç
  • A. Özbek
Original Article
  • 136 Downloads

Abstract

Objective

We initially tried to study the possible correlation between the severity of coronary artery disease (CAD) and serum neopterin levels in stable coronary artery disease patients. Also we tried to investigate the neopterin as an indicator for the extent of CAD using the Gensini score.

Methods

A total of 40 patients with stable angina pectoris who are chosen for coronary angiography were selected for the study. Before the angiography procedure, blood samples were taken for the measurement of serum neopterin levels and the results of the coronary angiography were scored according to the Gensini scoring system.

Results

Neopterin levels were correlated with the Gensini scores [p = 0.010, ρ = 0.401] and a correlation between the age of patient population and Gensini score was also observed in the study [p = 0.016, ρ = 0.380].

Conclusion

By the guidance of our results, we can confidently state that there is a correlation between serum neopterin levels and the severity and extent of CAD in stable coronary artery disease patients.

Keywords

Coronary artery disease Biomarkers Gensini scoring system Neopterin Stable Angina Pectoris CAD severity prediction 

Notes

Conflict of interest

None declared.

References

  1. 1.
    American Heart Association (2006) Heart Disease and Stroke Statistics—2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113:e85–e151CrossRefGoogle Scholar
  2. 2.
    Murray CJ, Lopez AD (1997) Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet 349:1436–1442PubMedCrossRefGoogle Scholar
  3. 3.
    Abdalla Abbas M, Guenther A, Galantucci S et al (2008) Microbial risk factors of cardiovascular and cerebrovascular diseases: potential therapeutical options. Open Neurol J 2:20–24PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Alizadeh Dehnavi R, de Roos A, Rabelink TJ et al (2008) Elevated CRP levels are associated with increased carotid atherosclerosis independent of visceral obesity. Atherosclerosis 200:417–423PubMedCrossRefGoogle Scholar
  5. 5.
    Sima AV, Stancu CS, Simionescu M (2009) Vascular endothelium in atherosclerosis. Cell Tissue Res 335:191–203PubMedCrossRefGoogle Scholar
  6. 6.
    Virani SS, Polsani VR, Nambi V (2008) Novel markers of inflammation in atherosclerosis. Curr Atheroscler Rep 10:164–170PubMedCrossRefGoogle Scholar
  7. 7.
    Zhang C (2008) The role of inflammatory cytokines in endothelial dysfunction. Basic Res Cardiol 103:398–406PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    Rizzo M, Corrado E, Coppola G et al (2009) Markers of inflammation are strong predictors of subclinical and clinical atherosclerosis in women with hypertension. Coron Artery Dis 20:15–20PubMedCrossRefGoogle Scholar
  9. 9.
    Huber C, Batchelor JR, Fuchs D et al (1984) Immune response-associated production of neopterin: release from macrophages primarily under control of interferon-gamma. J Exp Med 160:310–316PubMedCrossRefGoogle Scholar
  10. 10.
    Gupta S, Fredericks S, Schwartzman RA et al (1997) Serum neopterin in acute coronary syndromes. Lancet 349:1252–1253PubMedCrossRefGoogle Scholar
  11. 11.
    Garcia-Moll X, Cole D, Zouridakis E et al (2000) Increased serum neopterin: a marker of coronary artery disease activity in women. Heart 83:346–350PubMedCentralPubMedCrossRefGoogle Scholar
  12. 12.
    Avanzas P, Arroyo-Espliguero R, Cosin-Sales J et al (2004) Prognostic value of neopterin levels in treated patients with hypertension and chest pain but without obstructive coronary artery disease. Am J Cardiol 93:627–629PubMedCrossRefGoogle Scholar
  13. 13.
    Wachter H, Weiss G, Fuchs D (1993) Neopterin, biochemistry and clinical use as a marker for cellular immune reactions. Int Arch Allergy Immunol 101:1–6PubMedCrossRefGoogle Scholar
  14. 14.
    Saez-Llorens X, Lagrutt F (1993) The acute phase host reaction during bacterial infection and clinical impact in children. Pediatr Infect Dis J 12:83–87PubMedCrossRefGoogle Scholar
  15. 15.
    Blair J, Pfleiderer W, Wachter H. Biochemical and clinical aspects of pteridines. Biol Chem Hoppe-Seyler 1988;369:527–21Google Scholar
  16. 16.
    Werner ER, Werner-Felmayer G, Fuchs D et al (1990) Tetrahydrobiopterin biocynthetic activities in human macrophages, fibroblast, THP-1 and T24 cells. J Biol Chem 265:318–392Google Scholar
  17. 17.
    Werner ER, Bitterlich G, Fuchs D et al (1987) Human macrophages degrade trytophan upon induction by interferon-gamma. Life Sci 41:273–278PubMedCrossRefGoogle Scholar
  18. 18.
    Huber C, Fuchs D, Hausen A et al (1983) J Immunol 130(3):1047–1050PubMedGoogle Scholar
  19. 19.
    Andert SE, Griesmacher A, Zuckermann A et al (1992) Clin Exp Immunol 88(3):555–558PubMedCentralPubMedCrossRefGoogle Scholar
  20. 20.
    Berdowska A, Zwirska-Korczala K (2001) Neopterin measurement in clinical diagnosis. J Clin Pharm Ther 26:319–329PubMedCrossRefGoogle Scholar
  21. 21.
    Schumacher M, Halwachs G, Tatzber F et al (1997) Increased neopterin in patients with chronic and acute coronary syndromes. J Am Coll Cardiol 30(3):703–707PubMedCrossRefGoogle Scholar
  22. 22.
    Şahin M, Varol E, Ozaydin M et al (2008) Comparison of neopterin levels in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. South Med J 100:476–479Google Scholar
  23. 23.
    Zouridakis E, Avanzas P, Arroyo-Espliguero R et al (2004) Markers of inflammation and rapid coronary artery disease progression in patients with stable angına pectoris. Circulation 110:1747–1753PubMedCrossRefGoogle Scholar
  24. 24.
    Schobersberger W, Hoffman G, Grote J et al (1995) Induction of inducible nitric oxide synthase expression by neopterin in vascular smooth muscle cells. FEBS Lett 377:461–464PubMedCrossRefGoogle Scholar
  25. 25.
    Hoffmann G, Wirleitner B, Fuchs D (2003) Potential role of immune system activation-associated production of neopterin derivatives in humans. Inflamm Res 52:313–321PubMedCrossRefGoogle Scholar
  26. 26.
    Schrocksnadel K, Wirleitner B, Winkler C et al (2006) Monitoring tryptophan metabolism in chronic immune activation. Clin Chem Acta 364:82–90CrossRefGoogle Scholar
  27. 27.
    Fraser CC (2006) Exploring the positive and negative consequences of NFkappaB inhibition for the treatment of human disease. Cell Cycle 5:1160–1163PubMedCrossRefGoogle Scholar

Copyright information

© Royal Academy of Medicine in Ireland 2013

Authors and Affiliations

  • C. Özbek
    • 1
    Email author
  • İ. Baran
    • 1
  • A. Tütüncü
    • 1
  • T. Kuştarcı
    • 1
  • K. Karaağaç
    • 1
    • 2
  • A. Özbek
    • 1
    • 3
  1. 1.Department of CardiologyUludağ University School of MedicineBursaTurkey
  2. 2.Department of CardiologyBursa Yuksek Ihtisas Education and Resarch HospitalBursaTurkey
  3. 3.Department of Internal MedicineUludağ University School of MedicineBursaTurkey

Personalised recommendations