Irish Journal of Medical Science

, Volume 183, Issue 2, pp 319–321 | Cite as

A case of renal γ2 heavy-chain deposition disease accompanied by rapid progressive renal failure

  • G.-T. Chen
  • X.-H. Liao
  • R.-Y. Yan
  • Y. Li
  • L. ZhangEmail author
Brief Report



The recently described heavy-chain deposition disease (HCDD) is a comparatively rare monoclonal immunoglobulin disorder characterized histopathologically by glomerular and tubular basement membrane deposition of nonamyloidotic monoclonal heavy chains without associated light chains.


We have described a case of γ2-HCDD presenting with proteinuria, microhematuria, severe hypertension, and rapidly progressive renal failure, which serum creatinine level was only 1.52 mg/dL in early stage HCDD, and the clinicopathologic features of this case have been compared with other reported cases of γ2-HCDD.


Renal biopsy disclosed nodular sclerosing glomerulopathy. Immunofluorescence analysis revealed IgG2 (2+) heavy chain and C3 (+) in the mesangium and along the capillary walls and tubular basement membranes without IgA, IgM, κ and λ light chains. Electron microscopy revealed electron-dense deposits along the glomerular and tubular basement membranes as well as in the mesangium. Moreover, regardless of therapy, the condition of the patient progressively deteriorated, with less than 3 months of renal survival.


Rapid progressive renal failure was a common feature in both cases of γ2-HCDD. We propose that a possible link exists between prognosis of renal HCDD and the subclass of heavy chain deposited in the kidney.


Heavy-chain deposition disease Nodular glomerulosclerosis Renal failure 


Conflict of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.


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Copyright information

© Royal Academy of Medicine in Ireland 2013

Authors and Affiliations

  • G.-T. Chen
    • 1
  • X.-H. Liao
    • 1
  • R.-Y. Yan
    • 1
  • Y. Li
    • 1
  • L. Zhang
    • 1
    Email author
  1. 1.Department of NephrologyThe Second Affiliated Hospital, Chongqing Medical UniversityChongqingChina

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