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Clozapine-induced leukopenia: arguments for rechallenge

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References

  1. Latif Z, Malik MA, Jabbar F, Ahmed Y, McDonough C (2010) Clozapine-induced late leukopenia. Ir J Med Sci. doi: 10.1007/s11845-010-0587-y

  2. Bhanji NH, Margolese HC, Chouinard G, Turnier L (2003) Late-onset agranulocytosis in a patient with schizophrenia after 17 months of clozapine treatment. J Clin Psychopharmacol 23(5):522–523

    Article  PubMed  Google Scholar 

  3. Sedky K, Shaughnessy R, Hughes T, Lippmann S (2005) Clozapine-induced agranulocytosis after 11 years of treatment. Am J Psychiatry 162(4):814

    Article  PubMed  Google Scholar 

  4. Tamam L, Kulan E, Ozpoyraz N (2001) Late onset neutropenia during clozapine treatment. Psychiatry Clin Neurosci 55(5):547–548

    Article  PubMed  CAS  Google Scholar 

  5. Tiihonen J (2006) Fatal agranulocytosis 4 years after discontinuation of clozapine. Am J Psychiatry 163(1):161

    Article  PubMed  Google Scholar 

  6. Emea (2011) http://www.emea.europa.eu/pdfs/human/referral/603402en.pdf. Accessed 2 Feb 2011

  7. FDA (2011) http://www.fda.gov/cder/foi/label/2005/019758s056lbl.pdf. Accessed 2 Feb 2011

  8. Heimpel H (1991) The diseases. In: Kaufman DW, Kelly JP, Levy M, Shapiro S (eds) The drug etiology of agranulocytosis and aplastic anemia. Oxford University Press, New York/Oxford, pp 27–53

    Google Scholar 

  9. Dunk LR, Annan LJ, Andrews CD (2006) Rechallenge with clozapine following leucopenia or neutropenia during previous therapy. Br J Psychiatry 188:255–263

    Article  PubMed  Google Scholar 

  10. Netherlands Clozapine Collaboration Group (2009) Guideline for the use of clozapine. http://www.clozapinepluswerkgroep.nl

  11. Kanaan RA, Kerwin RW (2006) Lithium and clozapine rechallenge: a retrospective case analysis. J Clin Psychiatry 67:756–760

    Article  PubMed  CAS  Google Scholar 

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Conflict of interest

J. Bogers has no financial or other conflicting relationships. D. Cohen has received a grant from Eli-Lilly and Janssen and honoraria from Astra-Zeneca, Bristol-Myers-Squibb and Eli-Lilly. P. Schulte has received honoraria from Astra-Zeneca, Bristol-Myers-Squibb and Eli-Lilly. D. van Dijk has received a grant from Eli-Lilly. B. Bakker has no financial or other conflicting relationships.

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Correspondence to J. P. A. M. Bogers.

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The authors are members of the board of the Netherlands Clozapine Collaboration Group.

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Bogers, J.P.A.M., Cohen, D., Schulte, P.F.J. et al. Clozapine-induced leukopenia: arguments for rechallenge. Ir J Med Sci 181, 155–156 (2012). https://doi.org/10.1007/s11845-011-0782-5

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  • DOI: https://doi.org/10.1007/s11845-011-0782-5

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