Irish Journal of Medical Science

, Volume 180, Issue 3, pp 703–707 | Cite as

The effects of ozone therapy and coenzyme Q10 combination on oxidative stress markers in healthy subjects

  • M. İnal
  • A. Dokumacioglu
  • E. ÖzcelikEmail author
  • O. Ucar
Original Article



Ozone therapy is employed as a therapeutic agent in various diseases. Since ozone itself is a radical, using a small dosage of it is known to create an oxidative preconditioning in the body and trigger a strong antioxidant response against that. Coenzyme Q10, as a strong antioxidant agent, is delivered as a supportive factor in many diseases involving oxidative stress.


The aim of the study was to evaluate the effects of the combination treatment over oxidative stress in healthy individuals.


In the current study, 11 healthy volunteers were administered a combination of ozone therapy and Q10 for 1 month. Blood samples were collected first right after the initial ozone therapy and then 1 month after the ozone therapy + coenzyme Q10 treatment. We measured erythrocyte superoxide dismutase and catalase enzyme activities along with serum malondialdehyde levels.


Compared with the pretreatment values, an increase was determined in the erythrocyte superoxide dismutase and catalase enzyme activities. However, malondialdehyde, an indicator of oxidative membrane damage, showed a reduction after the combination treatment.


The results of this study reveal the beneficial effects of ozone therapy + coenzyme Q10 combination in prevention of oxidative damage.


Coenzyme Q10 Malondialdehyde Ozone therapy Oxidative stress Superoxide dismutase 



We thank Maya Sante Medical Center (Eskisehir) and its staff for providing samples from healthy subjects subjected to ozone therapy and Co Q10.

Conflict of interest

None declared.


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Copyright information

© Royal Academy of Medicine in Ireland 2011

Authors and Affiliations

  • M. İnal
    • 1
  • A. Dokumacioglu
    • 1
  • E. Özcelik
    • 1
    Email author
  • O. Ucar
    • 2
  1. 1.Department of Biochemistry, Medicine FacultyOsmangazi UniversityMeselik, EskisehirTurkey
  2. 2.Maya Sante Medical CenterEskisehirTurkey

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