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The effects of diet and orlistat on body weight and lipid profiles in high risk Chinese patients with coronary artery disease, obesity and hypercholesterolemia

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Abstract

Background

Orlistat is a gastrointestinal lipase inhibitor approved for use in obesity. So far, no evidence has been reported on the use of orlistat in obese patients with coronary artery disease (CAD).

Aim

To investigate the effect of orlistat on body weight and lipid profiles in obese patients with CAD and hypercholesterolemia.

Methods

Thirty non-diabetic patients with CAD, body mass index (BMI) ≥25 kg/m2 and low-density lipoprotein cholesterol (LDL-C) ≥2.6 and <4.1 mmol/L were put on diet for 12 weeks. Those still having a BMI ≥25 kg/m2 received orlistat 120 mg thrice daily for another 24 weeks.

Results

BMI was significantly reduced by 1.7% after 12 weeks of dietary treatment. The 24-week orlistat treatment resulted in further significant reduction in BMI (−2.8%) and LDL-C (−7.0%).

Conclusion

Diet and orlistat treatment significantly reduced BMI and improved LDL-C in obese patients with CAD and hypercholesterolemia.

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Acknowledgments

The authors are grateful to Roche Hong Kong Limited for providing drug samples to the study. The company did not participate in carrying out the study and writing up of this paper.

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Authors and Affiliations

  1. Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong SAR, China

    K. W. Chan, W. S. Leung, H. F. Hung & P. Tsui

  2. Department of Dietetics and Catering, Princess Margaret Hospital, Hong Kong SAR, China

    Y. S. Fung & H. Chu

  3. Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, China

    Y. W. Chan

  4. Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China

    G. T. C. Ko

  5. Department of Medicine and Geriatrics, Our Lady of Maryknoll Hospital, Hong Kong SAR, China

    V. T. F. Yeung

Authors
  1. K. W. Chan
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  2. W. S. Leung
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  3. Y. S. Fung
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  4. H. F. Hung
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  5. P. Tsui
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  6. H. Chu
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  7. Y. W. Chan
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  8. G. T. C. Ko
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  9. V. T. F. Yeung
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Corresponding author

Correspondence to G. T. C. Ko.

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Chan, K.W., Leung, W.S., Fung, Y.S. et al. The effects of diet and orlistat on body weight and lipid profiles in high risk Chinese patients with coronary artery disease, obesity and hypercholesterolemia. Ir J Med Sci 178, 173–178 (2009). https://doi.org/10.1007/s11845-009-0291-y

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  • DOI: https://doi.org/10.1007/s11845-009-0291-y

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