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Successful pregnancy after rituximab in a women with recurrent in vitro fertilisation failures and anti-phospholipid antibody positive

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Abstract

We report a case of successful pregnancy after rituximab in a patient with a history of in vitro fertilisation (IVF) failures and positive anti-cardiolipin antibody (ACA). Following a course of rituximab, her ACA became negative and she successfully conceived with IVF treatment. This is the first case in literature describing the use of rituximab therapy in this clinical scenario.

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References

  1. The European IVF-monitoring programme (EIM) for the European Society of Human Reproduction and Embryology (ESHRE), Andersen AN, Gianaroli L, Felberbaum R, de Mouzon J, Nygren KG. Assisted reproductive technology in Europe, 2002 (2006) Results generated from European Registers by ESHRE. Hum Reprod 21(7):1680–1697. Epub 2006 Apr 3

    Google Scholar 

  2. Kutteh WH (1997) Antiphospholipid antibodies and reproduction. J Reprod Immunol 35(2):151–171

    Article  CAS  PubMed  Google Scholar 

  3. Hornstein MD, Davis OK, Massey JB, Paulson RJ, Collins JA (2000) Antiphospholipid antibodies and in vitro fertilization success: a meta-analysis. Fertil Steril 73(2):330–333

    Article  CAS  PubMed  Google Scholar 

  4. Stern C, Chamley L, Norris H, Hale L, Baker HW (2003) A randomised, double-blind placebo controlled trial of heparin and aspirin for women with in vitro fertilization implantation failure and antiphospholipid or antinuclear antibodies. Fertil Steril 80(2):376–383

    Article  PubMed  Google Scholar 

  5. Empson M, Lassere M, Craig J, Scott J (2005) Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev 18(2):CD002859

    Google Scholar 

  6. Friedrichs B, Tiemann M, Salwender H, Verpoort K, Wenger MK, Schmitz N (2006) The effects of rituximab treatment during pregnancy on a neonate. Haematologica 91:1426–1427

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Bone and Joint Unit, Department of Rheumatology, St Vincent’s University Hospital, Elm Park, Dublin 4, Ireland

    C. T. Ng, M. O’Neil & D. J. Veale

  2. Sims Fertilty Clinic, Rosemount Hall, Dundrum Road, Dublin 14, Ireland

    D. Walsh & T. Walsh

Authors
  1. C. T. Ng
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  2. M. O’Neil
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  3. D. Walsh
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  4. T. Walsh
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  5. D. J. Veale
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Correspondence to C. T. Ng.

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Ng, C.T., O’Neil, M., Walsh, D. et al. Successful pregnancy after rituximab in a women with recurrent in vitro fertilisation failures and anti-phospholipid antibody positive. Ir J Med Sci 178, 531–533 (2009). https://doi.org/10.1007/s11845-008-0265-5

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  • DOI: https://doi.org/10.1007/s11845-008-0265-5

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