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Implication des tests neuropsychiques dans l’évaluation de la toxicité encéphalique après irradiation pour des métastases cérébrales

Neuropsychological tests role in the evaluation of the brain toxicity after irradiation for brain metastasis

  • Article Original / Original Article
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Psycho-Oncologie

Résumé

Les métastases cérébrales sont fréquentes dans l’évolution des cancers. L’irradiation encéphalique en totalité est un traitement incontournable. Les améliorations thérapeutiques ont conduit à une augmentation de la survie globale des patients. Les conséquences neuropsychiques de l’irradiation sont mal évaluées. Récemment, l’utilisation de tests multiples a permis de remettre en question le dogme de la toxicité cérébrale inéluctable de la radiothérapie. La première cause de détérioration neuropsychique est l’absence de contrôle cérébral de la maladie.

Abstract

Brain metastases are a frequent complication of many cancers. Whole brain irradiation is the main treatment of these. However, improvements of therapeutical efficiency increased life expectancy of patients with brain metastases. Consequences of whole brain irradiation include neurocognitive degradation, but this remains poorly evaluated. Recently, using of battery of neuropsychological tests led to question the dogma of the ineluctable brain toxicity of the radiotherapy. Analysis of the literature allows concluding that the first cause of deterioration of neurocognitive function after brain irradiation is the lack of brain disease control.

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  1. Département de radiothérapie, centre de lutte contre le cancer Pau-Strauss, 3, rue de la Porte de l’hôpital, BP 42, F-67065, Strasbourg cedex, France

    G. Noël, F. Guillerme & D. Antoni

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  1. G. Noël
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  2. F. Guillerme
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  3. D. Antoni
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Correspondence to G. Noël, F. Guillerme or D. Antoni.

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Noël, G., Guillerme, F. & Antoni, D. Implication des tests neuropsychiques dans l’évaluation de la toxicité encéphalique après irradiation pour des métastases cérébrales. Psycho Oncologie 4, 108–115 (2010). https://doi.org/10.1007/s11839-010-0259-1

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