Skip to main content
Log in

Dépression, anxiété, fatigue et troubles cognitifs : leur contribution à la qualité de vie des patients atteints de tumeurs cérébrales — Revue de la littérature

Depression, anxiety, fatigue and cognitive impairment: their contribution to brain tumor patients’ quality of life — Review

  • Article Original / Original Article
  • Published:
Psycho-Oncologie

Résumé

Les tumeurs cérébrales restent une maladie au pronostic très sombre, le concept de qualité de vie est donc fondamental dans cette population et est maintenant bien documenté. Il peut être affecté dans des proportions importantes par les troubles de l’humeur, la fatigue et les troubles cognitifs. Quelques interventions dans le domaine des soins de support ont montré des résultats prometteurs, et l’accent doit maintenant être mis sur le développement d’outils d’évaluation de ces soins de support, spécifiques à cette population.

Abstract

Brain tumor patients have a poor prognostic, so quality of life is a very important endpoint. Quality of life (QOL) is a multidimensional concept that could be affected by emotional disorders, fatigue and cognitive impairment among these patients. There are now some consistent findings on brain tumor patients’ QOL and some interventions have been studied with hopeful results. Further priorities have to be given to development of assessments of psychosocial and supportive cares’ intervention.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Références

  1. Anderson SI, Taylor R, Whittle IR (1999) Mood disorders in patients after treatment for primary intracranial tumours. Br J Neurosurg 13: 480–485

    PubMed  Google Scholar 

  2. Armstrong TS, Cron SG, Bolanos EV, et al (2010) Risk factors for fatigue severity in primary brain tumor patients. Cancer (publication en ligne)

  3. Arnold S, Forman L, Brigidi B, et al (2008) Evaluation and characterization of generalized anxiety and depression in patients with primary brain tumours. J Neurooncol 10:171–181

    Google Scholar 

  4. Bender CM, Sereika SM, Berga SL, et al (2006) Cognitive impairment associated with adjuvant therapy in breast cancer. Psychooncology 15:422–430

    Article  PubMed  Google Scholar 

  5. Brown ES (2009) Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy. Ann NY Acad Sci 1179:41–55

    Article  PubMed  Google Scholar 

  6. Brown PD, Maurer MJ, Rummans TA, et al (2005) A prospective study of quality of life in adults with newly diagnosed high-grade gliomas: the impact of the extent of resection on quality of life and survival. Neurosurgery 57(3):495–504

    Article  PubMed  Google Scholar 

  7. Calabrese P, Schelgel U (2009) Neurotoxicity of treatment. Recent Results Cancer Res 171:165–174

    Article  PubMed  Google Scholar 

  8. Catt S, Chalmers A, Fallowfield L (2008) Psychosocial and supportive-care in high grade glioma. Lancet Oncol 9:884–891

    Article  PubMed  Google Scholar 

  9. Correa DD (2006) Cognitive functions in brain tumor patients. Hematol Oncol Clin North Am 20(6):1363–1376

    Article  PubMed  Google Scholar 

  10. Correa DD, DeAngelis LM, Shi W, et al (2004) Cognitive functions in survivors of primary central nervous system lymphoma. Neurology 62:548–555

    PubMed  Google Scholar 

  11. Correa DD, DeAngelis LM, Shi W, et al (2007) Cognitive functions in low grade gliomas: disease and treatment effects. J Neurooncol 81:175–184

    Article  PubMed  Google Scholar 

  12. Correa DD, Maron L, Harder H (2007) Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines. Ann Oncol 18:1145–1151

    Article  PubMed  Google Scholar 

  13. Correa DD, Rocco-Donovan M, DeAngelis LM, et al (2009) Prospective cognitive follow-up in primary CNS lymphoma patients treated with chemotherapy and reduced-dose radiotherapy. J Neurooncol 91(3):315–321

    Article  PubMed  Google Scholar 

  14. D’Angelo C, Mirijello A, Leggio L, et al (2008) State and trait anxiety and depression in patients with primary brain tumors before and after surgery: 1-year longitudinal study. J Neurosurg 108:281–286

    Article  PubMed  Google Scholar 

  15. Fliessbach K, Helmastaedter C, Urbach H, et al (2005) Neuropsychological outcome after chemotherapy for primary CNS lymphoma: a prospective study. Neurology 64(7):1184–1188

    PubMed  Google Scholar 

  16. Fliessbach K, Urbach H, Helmstaedter C, et al (2003) Cognitive performance and magnetic resonance imaging findings after high-dose systemic and intraventricular chemotherapy for central nervous system lymphoma. Arch Neurol 60:563–568

    Article  PubMed  Google Scholar 

  17. Fobair P, Mackworth N, Varghese A, Prados M (1990) Quality of life issues among 200 brain tumor patients treated at the university of California in San Francisco, interviewed in 1998. Presented at the Brain Tumor conference: a living resource guide. San Francisco, California

  18. Freilich RJ, Delattre JY, Monjour A, DeAngelis LM (1996) Chemotherapy without radiation therapy as initial treatment for primary CNS lymphoma in older patients. Neurology 46(2):435–439

    PubMed  Google Scholar 

  19. Gehring K, Sitskoorn MM, Sikkes SA, et al (2009) Cognitive rehabilitation in patients with gliomas: a randomized, controlled trial. J Clin Oncol 27(22):3712–3722

    Article  PubMed  Google Scholar 

  20. Giovagnoli AR (1999) Quality of life in patients with stable disease after surgery, radiotherapy and chemotherapy for malignant brain tumor. J Neurol Neurosurg Psychiatry 67(2):358–363

    Article  PubMed  Google Scholar 

  21. Giovagnoli AR, Silvani A, Colombo E, Boiardi A (2005) Facets and determinants of quality of life in patients with recurrent high grade glioma. J Neurol Neurosurg Psychiatry 76(4):562–568

    Article  PubMed  Google Scholar 

  22. Grant R, Slattery J, Gregor A, et al (1994) Recording neurological impairment in clinical trials of glioma. J Neurooncol 19:37–49

    Article  PubMed  Google Scholar 

  23. Jansen C, Miaskowsky C, Dodd M, et al (2005) Potential mechanisms for chemotherapy-induced impairments in cognitive functions. Oncol Nurs Forum 32(6):1151–1163

    Article  PubMed  Google Scholar 

  24. Kier ST, Farland MM, Lipp ES, Friedman HS (2008) Distress persists in long-term brain tumor survivors with glioblastoma multiforme. J Cancer Surviv 2(4):269–274

    Article  Google Scholar 

  25. Klein M, Engelberts NH, Van der Ploeg HM, et al (2003) Epilepsie in low-grade gliomas: the impact on cognitive function and quality of life. Ann Neurol 54(4):514–520

    Article  PubMed  Google Scholar 

  26. Klein M, Heimans J, Aaronson N, et al (2002) Effect of radiotherapy and other treatment-related factors on mid-term to long-term cognitive sequelae in low-grade gliomas: a comparative study. Lancet 360(9343):1361–1368

    Article  PubMed  Google Scholar 

  27. Levin VA (1999) Neuro-oncology: an overview. Arch Neurol 56:401–404

    Article  PubMed  Google Scholar 

  28. Litofsky N, Scott M, Farace E, et al (2004) Depression in patients with high-grade glioma: results of the Glioma Outcomes Project. J Neurosurg 54(2):358–367

    Article  Google Scholar 

  29. Locke DE, Cerhan JH, Wu W, et al (2008) Cognitive rehabilitation and problem solving to improve quality of life of patients with primary brain tumors: a pilot study. J Support Oncol 6(8):383–391

    PubMed  Google Scholar 

  30. Lovely MP, Miaskowski C, Dodd M (1999) Relationship between fatigue and quality of life in patients with Glioblastoma Multiformae. Oncol Nurs Forum 26:921–925

    PubMed  Google Scholar 

  31. Mainio A, Hakko H, Niemela A, et al (2003) The effect of brain tumour laterality on anxiety levels among neurosurgical patients. J Neurol Neurosurg Psychiatry 74:1278–1282

    Article  PubMed  Google Scholar 

  32. Mainio A, Hakko H, Niemelä A, et al (2006) Gender difference in relation to depression and quality of life among patients with a primary brain tumor. Eur Psychiatry 21(3):194–199

    Article  PubMed  Google Scholar 

  33. Mainio A, Tuunanen S, Hakko H, et al (2006) Decreased quality of life and depression as predictors for shorter survival among brain tumor patients with low-grade gliomae: a follow up from 1990 to 2003. Eur Arch Psychiatry Clin Neurosci 256:516–521

    Article  PubMed  Google Scholar 

  34. Meyers CA, Hess KR, Yung WKA, Levin VA (2000) Cognitive function as a predictor of survival in patients with recurrent malignant glioma. J Clin Oncol 8(3)646–650

    Google Scholar 

  35. Myers JS (2009) Chemotherapy-related cognitive impairment. Clin J Oncol Nurs 13(4):413–421

    Article  PubMed  Google Scholar 

  36. Myers JS, Pierce J, Pazdernik T (2008) Neurotoxicology of chemotherapy in relation to cytokine release, the blood-brain barrier, and cognitive impairment. Oncol Nurs Forum 35(6):916–920

    Article  PubMed  Google Scholar 

  37. Nelson CJ, Nandy N, Roth AJ (2007) Chemotherapy and cognitive deficits: mechanisms, findings, and potential interventions. Palliat Support Care 5(3):273–280

    PubMed  Google Scholar 

  38. Nicholson HS, Kretschmar CS, Kralio M, et al (2007) Phase II study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children’s Oncology Group. Cancer 110:1542–1550

    Article  PubMed  Google Scholar 

  39. Osoba D, Brada M, Prados MD, Yung WK (2000) Effect of disease burden on health-related quality of life in patients with malignant glioma. Neurooncol 1:221–228

    Google Scholar 

  40. Pelletier G, Verhoef M, Khatri N, Hagan N (2002) Quality of life in brain tumor patients: the relative contributions of fatigue, emotional distress and existential issues. J Neuro Oncol 57:41–49

    Article  Google Scholar 

  41. Pirl WF (2004) Evidence report on the occurrence, assessment and treatment of depression in cancer patients. J Natl Cancer Inst Monogr 32:32–39

    Article  PubMed  Google Scholar 

  42. Pringle AM, Taylor R, Whittle IR (1999) Anxiety and depression in patients with an intracranial neoplasm before and after tumour surgery. Br J Neurosurg 13(1):46–51

    Article  PubMed  Google Scholar 

  43. Rooney A, Grant R (2010) Pharmacological treatment of depression in patients with a primary brain tumour (review). Cochrane Database Syst Rev 3:CD006932

    PubMed  Google Scholar 

  44. Saykin AJ, Ahles TA, McDonald BC (2003) Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perpectives. Semin Clin Neuropsychiatry 8(4):201–216

    PubMed  Google Scholar 

  45. Scheibel RS, Meyers CA, Levin VA (1996) Cognitive dysfunction following surgery for intracerebral glioma: influence of histopathology, lesion location and treatment. J Neurooncol 30:61–69

    Article  PubMed  Google Scholar 

  46. Sherer M, Meyers CA, Bergloff P (1997) Efficacy of postacute brain injury rehabilitation for patients with primary malignant brain tumors. Cancer 80(2):250–257

    Article  PubMed  Google Scholar 

  47. Sierra del Rio M, Rousseau A, Soussain C, et al (2009) Primary CNS lymphoma in immunocompetent patients. Oncologist 14:526–539

    Article  PubMed  Google Scholar 

  48. Soussain C, Ricard D, Fike JR, et al (2009) CNS complications of radiotherapy and chemotherapy. Lancet 374:1639–1651

    Article  PubMed  Google Scholar 

  49. Taillibert S, Voillery D, Bernard-Marty C (2007) Chemobrain: is systemic chemotherapy neurotoxic? Curr Opin Oncol 19:623–627

    Article  PubMed  Google Scholar 

  50. Tannock IF, Ahles TA, Ganz PA, Van Dam FS (2004) Cognitive impairment associated with chemotherapy for cancer: report of a workshop. J Clin Oncol 22(11):2233–2239

    Article  PubMed  Google Scholar 

  51. Wick A, Flesberg J, Steinbach JP, et al (2007) Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma. J Clin Oncol 25:3357–3361

    Article  PubMed  Google Scholar 

  52. Zabora J, Brintzenhofeszoc K, Curbow B, et al (2001) The prevalence of psychological distress by cancer site. Psycho-oncology 10(1):19–28

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to N. Jouniaux-Delbez, D. Delgadillo or S. Taillibert.

About this article

Cite this article

Jouniaux-Delbez, N., Delgadillo, D. & Taillibert, S. Dépression, anxiété, fatigue et troubles cognitifs : leur contribution à la qualité de vie des patients atteints de tumeurs cérébrales — Revue de la littérature. Psycho Oncologie 4, 116–122 (2010). https://doi.org/10.1007/s11839-010-0255-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11839-010-0255-5

Mots clés

Keywords

Navigation