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Homogenized Macroscale Model and Morphological Microscale Model to Understand the Varying Mechanical Properties of Scar Tissue of Hip Capsule Ligaments Grown Around Different Implant Materials

  • Multiscale Experiments and Modeling in Biomaterials and Biological Materials
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A Correction to this article was published on 25 March 2024

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Abstract

In total hip arthroplasty, the hip joint is replaced by artificial materials. The fibrous tissue that re-forms around the hip joint after surgery plays an important role in joint stability. Here, the morphological and mechanical properties of the scar tissue that forms around implants composed of either polymer and metal or ceramic are compared with native tissue removed during an initial total hip arthroplasty. Immunohistological analyses of the samples revealed different hierarchical structures of the tissues over three scales: the fiber, the fascicle, and tissue scales. At the tissue scale, microtensile tests were performed on millimetric samples and their nonlinear elastic responses identified by either an exponential law or Ogden third-order constitutive model. At the fiber scale, a patient-specific microscale finite element model was used ,including the measured morphological parameters and distinct Ogden constitutive models for the fiber and matrix composed of a mixture of fibers in ground substance.

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Acknowledgements

The authors are grateful for the support from Agence Nationale de la recherche et de la Technologie (ANRT) CIFRE Award No. 2018/1806 in collaboration with the company CC CONTACT. The third author is now at UMS 3750, Pierre Gilles de Gennes Institute, Paris, France. The authors declare they have no conflicts of interest.

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Authors and Affiliations

  1. CNRS-Inserm Laboratory of Osteoarticular Biology, Bioimaging and Bioengineering B3OA UMR7052 U1172, University of Paris, 75010, Paris, France

    Angelina Avgeri & Laurent Sedel

  2. Department of Mechanical Engineering, CNRS Laboratory of Mechanics and Technology LMT UMR8535, École Normale Supérieure Paris-Saclay, University Paris-Saclay, 91190, Gif-sur Yvette, France

    Samantha Sanders & Elisa Budyn

  3. Department of Othopedic Surgery, CNRS-Inserm Laboratory of Osteoarticular Biology, Bioimaging and Bioengineering B3OA UMR7052 U1172, University of Paris, 75010, Paris, France

    Pascal Bizot

  4. CNRS Laboratory of Biology and Applied Pharmacology LBPA UMR8113, École Normale Supérieure Paris-Saclay, University Paris-Saclay, 91190, Gif-sur Yvette, France

    Bertrand Cinquin

Authors
  1. Angelina Avgeri
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  2. Samantha Sanders
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  3. Bertrand Cinquin
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  4. Laurent Sedel
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  5. Pascal Bizot
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  6. Elisa Budyn
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Correspondence to Elisa Budyn.

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Avgeri, A., Sanders, S., Cinquin, B. et al. Homogenized Macroscale Model and Morphological Microscale Model to Understand the Varying Mechanical Properties of Scar Tissue of Hip Capsule Ligaments Grown Around Different Implant Materials. JOM 73, 2377–2389 (2021). https://doi.org/10.1007/s11837-021-04737-4

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  • DOI: https://doi.org/10.1007/s11837-021-04737-4

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