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Stimuli-Responsive Nano-polymer Composite Materials Based on the Triazine Skeleton Structure Used in Drug Delivery

  • Materials in Nanomedicine and Bioengineering
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Abstract

Herein, we exploit the unique structure, high surface area and porous structure of covalent triazine polymers (CTP) for efficient and targeted drug delivery. We have designed and synthesized a nano-covalent triazine polymer (NCTP) by using Friedel–Crafts reactions and utilized it as a drug carrier for controlled release. The salient features of as-prepared NCTP include excellent dispersibility in physiologic solution and structural stability. Furthermore, we have achieved excellent loading of doxorubicin (DOX), an anticancer drug, onto the NCTP by utilizing the π–π interactions and hydrophobic nature. The toxicity of as-prepared NCTP was assessed by CaSki and HeLa cells, and high efficacy in vitro against both types of cells has been demonstrated.

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Acknowledgements

The authors acknowledge financial support from the Corps Division Development and Innovation Support Program (2017BA041), National Natural Science Foundation of China (51662036) and Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bintuan (2016BTRC008 and 2016BTRC005).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Shihezi, 832003, Xinjiang, People’s Republic of China

    Xueying Peng, Lulu Wei, Xinbo Jing, Jianning Wu, Guihua Meng, Zhiyong Liu & Xuhong Guo

  2. School of Medicine, Shihezi University, Shihezi, 832003, Xinjiang, People’s Republic of China

    Lin Cui

  3. State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China

    Xuhong Guo

  4. School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Beisi Road, Shihezi, 832003, Xinjiang, People’s Republic of China

    Zhiyong Liu

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  1. Xueying Peng
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  2. Lulu Wei
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  4. Lin Cui
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Correspondence to Zhiyong Liu.

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Peng, X., Wei, L., Jing, X. et al. Stimuli-Responsive Nano-polymer Composite Materials Based on the Triazine Skeleton Structure Used in Drug Delivery. JOM 71, 308–314 (2019). https://doi.org/10.1007/s11837-018-3214-4

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  • DOI: https://doi.org/10.1007/s11837-018-3214-4

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