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Cytotoxicity of Bacteriostatic Reduced Graphene Oxide-Based Copper Oxide Nanocomposites

  • Materials in Nanomedicine and Bioengineering
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Abstract

An antibacterial nanocomposite, reduced graphene oxide-based copper oxide (CuO-RGO), was prepared by a one-step hydrothermal method and characterized by x-ray diffraction analysis, infrared absorption spectroscopy, scanning electron microscopy, transmission electron microscopy, and photoluminescence measurements, revealing CuO nanoparticles with diameter of about 26 nm uniformly anchored on graphene sheets. Compared with recently reported bacteriostatic agents, much less CuO-RGO is required and better bacteriostatic effect is achieved, with good stability. The minimum inhibitory concentration of the CuO-RGO composite against Escherichia coli reached 240 μg mL−1. The antibacterial rate remained at 89% after five cycles. In addition, introduction of graphene inhibited leaching of Cu2+, which reduces the cytotoxicity of CuO-RGO to mouse fibroblast L929.

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Acknowledgements

The authors are grateful for financial support from the National Nature Science Foundation of China (Nos. 51572036, 51472035), Science and Technology Department of Jiangsu Province (BY2015027-18, BY2016029-12), Changzhou Key Laboratory of Graphene-Based Materials for Environment and Safety (CE20160001-2, CM20153006), and PAPD of Jiangsu Higher Education Institution.

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  1. Key Laboratory of Advanced Catalytic Materials and Technology, Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou, 213164, Jiangsu Province, China

    Xiangyang Xu, Jing Shen, Jingyu Qin, Huimin Duan, Guangyu He & Haiqun Chen

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  1. Xiangyang Xu
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Xu, X., Shen, J., Qin, J. et al. Cytotoxicity of Bacteriostatic Reduced Graphene Oxide-Based Copper Oxide Nanocomposites. JOM 71, 294–301 (2019). https://doi.org/10.1007/s11837-018-3197-1

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  • DOI: https://doi.org/10.1007/s11837-018-3197-1

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