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New Bismuth-Substituted Hydroxyapatite Nanoparticles for Bone Tissue Engineering

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Abstract

New bismuth-substituted hydroxyapatite [Ca10−x Bi x (PO4)6(OH)2 where x = 0–2.5] nanoparticles were synthesized by the co-precipitation method from aqueous solutions. The structural properties of the samples were analyzed by scanning electron microscopy coupled with x-ray analysis, x-ray powder diffraction, x-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and Brunauer–Emmett–Teller surface area analysis. The results confirm that bismuth ions have been incorporated into the hydroxyapatite lattice. The prepared nanocrystalline powders consisted of hydroxyapatite as single phase with hexagonal structure, crystal sizes smaller than 60 nm and (Bi + Ca)/P atomic ratio of around 1.67. The hydroxyapatite samples doped with Bi have mesoporous textures with pores size of around 2 nm and specific surface area in the range of 12–25 m2/g. The Bi-substituted hydroxyapatite powders are more effective against Gram-negative Escherichia coli bacteria than Gram-positive Staphylococcus aureus bacteria.

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Authors and Affiliations

  1. Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, Prof. Dr. Docent Dimitrie Mangeron Rd., No. 63, 700050, Iasi, Romania

    Gabriela Ciobanu, Ana Maria Bargan & Constantin Luca

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  1. Gabriela Ciobanu
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  2. Ana Maria Bargan
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  3. Constantin Luca
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Correspondence to Gabriela Ciobanu.

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Ciobanu, G., Bargan, A.M. & Luca, C. New Bismuth-Substituted Hydroxyapatite Nanoparticles for Bone Tissue Engineering. JOM 67, 2534–2542 (2015). https://doi.org/10.1007/s11837-015-1467-8

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  • DOI: https://doi.org/10.1007/s11837-015-1467-8

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