Skip to main content

Advertisement

SpringerLink
Log in

Calcium phosphate ceramics in drug delivery

  • Biomaterials for Regenerative Medicine
  • Overview
  • Published:
JOM Aims and scope Submit manuscript

Abstract

Calcium phosphate (CaP) particulates, cements and scaffolds have attracted significant interest as drug delivery vehicles. CaP systems, including both hydroxyapaptite and tricalcium phosphates, possess variable stoichiometry, functionality and dissolution properties which make them suitable for cellular delivery. Their chemical similarity to bone and thus biocompatibility, as well as variable surface charge density contribute to their controlled release properties. Among specific research areas, nanoparticle size, morphology, surface area due to porosity, and chemistry controlled release kinetics are the most active. This article discusses CaP systems in their particulate, cements, and scaffold forms for drug, protein, and growth factor delivery toward orthopedic and dental applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E.I. Shishatskaya, O.N. Voinova, A.V. Goreva, O.A. Mogilnaya, and T.G. Volova, J. Mater. Sci: Mater. Med., 19 (2008), pp. 2493–2502.

    Article  CAS  Google Scholar 

  2. J.A. Hunt and M.S. Shoichet, Curr. Opin. Solid State Mater. Sci., 6 (2002), p. 281.

    Article  Google Scholar 

  3. M. Ye, S. Kim, and K. Park, J. Controlled Release, 146 (2010), pp. 241–260.

    Article  CAS  Google Scholar 

  4. P. Malafaya, Curr. Opin. Solid State Mater. Sci., 6 (2002), pp. 283–295.

    Article  CAS  Google Scholar 

  5. C. Tourné-Péteilh, D.A. Lerner, C. Charnay, L. Nicole, S. Bégu, and J. Devoisselle, J. Chem. Phys. Chem., 4 (2003), pp. 281–286.

    Google Scholar 

  6. E. Verron, I. Khairoun, J. Guicheux, and J. Bouler, Drug Discovery Today, 15 (2010), pp. 547–552.

    Article  CAS  Google Scholar 

  7. Michael A. Rauschmann, Thomas A. Wichelhaus, Volker Stirnal, Elvira Dingeldein, Ludwig Zichner, Reinhard Schnettler, and Volker Alt, Biomaterials, 26(15), (2005), pp. 2677–2684.

    Article  CAS  Google Scholar 

  8. Y. Ueno, H. Futagawa, Y. Takagi, A. Ueno, and Y. Mizushima, J. Controlled Release, 103(1) (2005), pp. 93–98.

    Article  CAS  Google Scholar 

  9. S.S. Banerjee, S. Tarafder, N.M. Davies, A. Bandyopadhyay, and S. Bose, Acta Biomater., 6 (2010), pp. 4167–4174.

    Article  CAS  Google Scholar 

  10. A. Bandyopadhyay, S. Bernard, W. Xue, and S. Bose, J. Amer. Cer. Soc., 89 (2006), pp. 2675–2688.

    Article  CAS  Google Scholar 

  11. D.S. Metsger, M.R. Rieger, and D.W. Foreman, J. Mater. Sci.: Mater. Med., 10 (1999), pp. 9–17.

    Article  CAS  Google Scholar 

  12. P. Sibilla, A. Sereni, G. Aguiari, M. Banzi, E. Manzati, C. Mischiati, L. Trombelli, and L. del Senno, J. Dental Res., 85 (2006), pp. 354–358.

    Article  CAS  Google Scholar 

  13. B. Palazzo, M. Iafisco, M. Laforgia, N. Margiotta, G. Natile, C. Bianchi, D. Walsh, S. Mann, and N. Roveri, Adv. Funct. Mater., 17 (2007), pp. 2180–2188.

    Article  CAS  Google Scholar 

  14. S. Dasgupta, S.S. Banerjee, A. Bandyopadhyay, and S. Bose, Langmuir, 26 (2010), pp. 4958–4964.

    Article  CAS  Google Scholar 

  15. F. Caruso, Adv. Mater., 13 (2001), pp. 11–22.

    Article  CAS  Google Scholar 

  16. F. Ye, H. Guo, H. Zhang, and X. He, Acta Biomater., 6 (2010), pp. 2212–2218.

    Article  CAS  Google Scholar 

  17. S. Dasgupta, A. Bandyopadhyay, and S. Bose, Acta Biomater., 5 (2009), pp. 3112–3121.

    Article  CAS  Google Scholar 

  18. W. Xue, A. Bandyopadhyay, and S. Bose, Acta Biomater., 5 (2009), pp. 1686–1696.

    Article  CAS  Google Scholar 

  19. S. Bose and S.K. Saha, Chem. Mater., 15 (2003), pp. 4464–4469.

    Article  CAS  Google Scholar 

  20. H.C. Shum, A. Bandyopadhyay, S. Bose, and D.A. Weitz, Chem. Mater., 21 (2009), pp. 5548–5555.

    Article  CAS  Google Scholar 

  21. M. Ravelingien, N. Smets, S. Mullens, J. Luyten, C. Vervaet, and J.P. Remon, IFMBE Proceed., 22 (2009), pp. 2269–2272.

    Article  Google Scholar 

  22. S.K. Nandi, P. Mukherjee, S. Roy, B. Kundu, D.K. De, and D. Basu, Mater. Sci. Eng.: C, 29 (2009), pp. 2478–2485.

    Article  CAS  Google Scholar 

  23. S.S. Banerjee, M. Roy, and S. Bose, Adv. Eng. Mater., 13(1–2) (2011), pp. B10–B17.

    Article  Google Scholar 

  24. T. Liu, S. Chen, D. Liu, and S. Liou, J. Control Release, 107 (2005), pp. 112–121.

    Article  CAS  Google Scholar 

  25. M. Bohner, J. Mater. Chem., 17 (2007), p. 3980.

    Article  CAS  Google Scholar 

  26. M. Bohner, T.J. Brunner, and W.J. Stark, J. Mater. Chem., 18(46) (2008), pp. 5669–5675.

    Article  Google Scholar 

  27. T.J. Brunner, R.N. Grass, M. Bohner, and W.J. Stark, J. Mater. Chem., 17 (2007), p. 4072.

    Article  CAS  Google Scholar 

  28. E. Fernandez, M. Boltong, M. Ginebra, F. Driessens, O. Bermudez, J. Planell, J. Mater. Sci. Lett., 15 (1996), pp. 1004–1005.

    Article  CAS  Google Scholar 

  29. M. Ginebra, F. Driessens, J. Planell, Biomaterials, 25 (2004), pp. 3453–3462.

    Article  CAS  Google Scholar 

  30. M.P. Ginebra, M.G. Boltong, E. Fernandez, J.A. Planell, and F.C.M. Driessens, J. Mater. Sci.: Mater. Med., 6 (1995), pp. 612–616.

    Article  CAS  Google Scholar 

  31. T. Yu, J. Ye, C. Gao, L. Yu, and Y. Wang, J. Amer. Cer. Soc., 93 (2010), pp. 1241–1244.

    CAS  Google Scholar 

  32. H.P. Stallmann, C. Faber, A.L. Bronckers, N. Amerongen, V. Arie, and P.I. Wuisman, BMC Musculoskeletal Disorders, 7(1) (2006), p. 18.

    Article  Google Scholar 

  33. S. Hesaraki and R. Nemati, J. Biomed. Mater. Res., 89B (2009), pp. 342–352.

    Article  CAS  Google Scholar 

  34. Z. Yang, D. Li, J. Han, J. Li, X. Li, Z. Li, and S. Li, Orthoped., 32(1) (2009), p. 27.

    Article  CAS  Google Scholar 

  35. E.J. Blom, J. Klein-Nulend, C.P.A.T. Klein, K. Kurashina, M.A.J. van Waas, and E.H. Burger, J. Biomed. Mater. Res., 50 (2000), pp. 67–74.

    Article  CAS  Google Scholar 

  36. M.D. Weir and H.H. Xu, J. Biomed. Mater. Res., 85A (2008), pp. 388–396.

    Article  CAS  Google Scholar 

  37. N. Ikawa, T. Kimura, Y. Oumi, and T. Sano, J. Mater. Chem., 19 (2009), p. 4906.

    Article  CAS  Google Scholar 

  38. H.P. Stallmann, R.D. Roo, C. Faber, A.V.N. Amerongen, and P.I. Wuisman, J. Orthop. Res., 26 (2008), pp. 531–538.

    Article  CAS  Google Scholar 

  39. H.P. Stallmann, J. Antimicrob. Chemother., 54 (2004), pp. 472–476.

    Article  CAS  Google Scholar 

  40. T. Niikura, K. Tsujimoto, S. Yoshiya, K. Tadokoro, M. Kurosaka, and R. Shiba, Orthoped., 30 (2007), p. 320.

    Google Scholar 

  41. R.A. Mickiewicz, A.M. Mayes, and D. Knaack, J. Biomed. Mater. Res., 61 (2002), pp. 581–592.

    Article  CAS  Google Scholar 

  42. R.M. Khashaba et al., Int. J. Biomater., 2010; Article 691452:1-14; doi:10.1155/2010/691452.

  43. Y. Zhang, and M. Zhang, J. Biomed. Mater. Res., 62 (2002), pp. 378–386.

    Article  CAS  Google Scholar 

  44. A. Bigi, B. Bracci, and S. Panzavolta, Biomaterials, 25 (2004), pp. 2893–2899.

    Article  CAS  Google Scholar 

  45. S. Panzavolta, P. Torricelli, B. Bracci, M. Fini, and A. Bigi, J. Inorg. Biochem., 104 (2010), pp. 1099–1106.

    Article  CAS  Google Scholar 

  46. M.D. Weir and H.H. Xu, Acta Biomater., 6 (2010), pp. 4118–4126.

    Article  CAS  Google Scholar 

  47. M. Ginebra, T. Traykova, and J. Planell, J. Controlled Release, 113 (2006), pp. 102–110.

    Article  CAS  Google Scholar 

  48. Z. Amjad, Calcium Phosphates in Biological and Industrial Systems (New York: Springer, 1997).

    Google Scholar 

  49. W. Xue, A. Bandyopadhyay, and S. Bose, J. Biomed. Mater. Res. Part B: Appl. Biomater., 91 (2009), pp. 831–838.

    Article  Google Scholar 

  50. J. Darsell, S. Bose, H.L. Hosick, and A. Bandyopadhyay, J. Amer. Cer. Soc., 86(7) (2003), pp. 1076–1080.

    Article  CAS  Google Scholar 

  51. Y. Kuboki, H. Takita, D. Kobayashi, E. Tsuruga, M. Inoue, M. Murata, N. Nagai, Y. Dohi, and H. Ohgushi, J. Biomed. Mater. Res., 39 (1998), pp. 190–199.

    Article  CAS  Google Scholar 

  52. S. Bose, J. Darnell, M. Kinter, H.L. Hosick, and A. Bandyopadhyay, Mater. Sci. & Eng., 23 (2003), pp. 479–486.

    Google Scholar 

  53. S. Bose, S. Suguira, and A. Bandyopadhyay, Scripta Mater., 41 (1999), pp. 1009–1014.

    Article  CAS  Google Scholar 

  54. S. Yang, K. Leong, Z. Du, and C. Chua, Tissue Eng., 8 (2002), pp. 1–11.

    Article  CAS  Google Scholar 

  55. V. Karageorgiou and D. Kaplan, Biomaterials, 26 (2005), pp. 5474–5491.

    Article  CAS  Google Scholar 

  56. J. Guicheux, O. Gauthier, E. Aguado, P. Pilet, S. Couillaud, D. Jegou, G. Daculsi, and D. Heymann, J. Bone Miner. Res., 13 (1998), pp. 739–748.

    Article  CAS  Google Scholar 

  57. J.A. Koempel, B.S. Patt, K. O’Grady, J. Wozney, and D.M. Toriumi, J. Biomed. Mater. Res., 41 (1998), pp. 359–363.

    Article  CAS  Google Scholar 

  58. B. Kundu, C. Soundrapandian, S.K. Nandi, P. Mukherjee, N. Dandapat, S. Roy, B.K. Datta, T.K. Mandal, D. Basu, and R.N. Bhattacharya, Pharm. Res., 27 (2010), pp. 1659–1676.

    Article  CAS  Google Scholar 

  59. J.G. Dellinger, J.A.C. Eurell, and R.D. Jamison, J. Biomed. Mater. Res., 76A (2006, pp. 366–376.

    Article  CAS  Google Scholar 

  60. S.K. Lan Levengood, S.J. Polak, M.J. Poellmann, D.J. Hoelzle, A.J. Maki, S.G. Clark, M.B. Wheeler, and A.J. Wagoner Johnson, Acta Biomater., 6 (2010), pp. 3283–3291

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164-2920, USA

    Susmita Bose, Solaiman Tarafder, Joe Edgington & Amit Bandyopadhyay

Authors
  1. Susmita Bose
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Solaiman Tarafder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joe Edgington
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Amit Bandyopadhyay
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susmita Bose.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bose, S., Tarafder, S., Edgington, J. et al. Calcium phosphate ceramics in drug delivery. JOM 63, 93–98 (2011). https://doi.org/10.1007/s11837-011-0065-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11837-011-0065-7

Keywords

Search

Navigation