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L’addiction: lorsque l’emballement des mécanismes d’apprentissage conduit à la perte du libre arbitre

Addiction: from learning to compulsion

  • Psychopathologie Cognitive / Cognitive Psychopatology
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Résumé

L’addiction est désormais envisagée comme un apprentissage pathologique responsable d’un surentraînement et d’une altération des mécanismes de prise de décision, entraînant une perte de contrôle du comportement. Bien qu’engagé systématiquement après exposition aux substances, ce processus ne se déroule jusqu’à la compulsion que chez certains individus vulnérables.

Abstract

Addiction disease is a form of pathological learning responsible for overlearning and ultimately leading to the loss of behavioural control. This process, while systematically engaged after exposure to drugs, only leads to compulsion in some of the more vulnerable addictive drug users.

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Références

  1. Andlin-Sobocki P, Jonsson B, Wittchen HU, Olesen J (2005) Cost of disorders of the brain in Europe. Eur J Neurol 12(Suppl 1):1–27

    Article  PubMed  Google Scholar 

  2. Belin D, Everitt BJ (2008) Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron 57:432–441

    Article  PubMed  CAS  Google Scholar 

  3. Bellone C, Lüscher C (2006) Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression. Nat Neurosci 9:636–641

    Article  PubMed  CAS  Google Scholar 

  4. Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28:309–369

    Article  PubMed  CAS  Google Scholar 

  5. Carr DB, Kalivas PW (2008) Confused about NMDA and addiction? Targeted knockouts provide answers and new questions. Neuron 59:353–355

    Article  PubMed  CAS  Google Scholar 

  6. Engblom D, Bilbao A, Sanchis-Segura C, et al (2008) Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron 59:497–508

    Article  PubMed  CAS  Google Scholar 

  7. Everitt BJ, Belin D, Economidou D, et al (2008) Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci 363:3125–3135

    Article  PubMed  Google Scholar 

  8. Goldman D, Oroszi G, Ducci F (2005) The genetics of addictions: uncovering the genes. Nat Rev Genet 6:521–532

    Article  PubMed  CAS  Google Scholar 

  9. Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29:565–598

    Article  PubMed  CAS  Google Scholar 

  10. Koob GF (2008) A role for brain stress systems in addiction. Neuron 59:11–34

    Article  PubMed  CAS  Google Scholar 

  11. Kreek M, Nielsen DA, Butelman ER, LaForge KS (2005) Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci 8:1450–1457

    Article  PubMed  CAS  Google Scholar 

  12. Lüscher C, Bellone C (2008) Cocaine-evoked synaptic plasticity: a key to addiction? Nat Neurosci 11:737–738

    Article  PubMed  Google Scholar 

  13. Lüscher C, Ungless MA (2006) The mechanistic classification of addictive drugs. PLoS Med 3:e437

    Article  PubMed  Google Scholar 

  14. Mameli M, Balland B, Lujàn R, Lüscher C (2007) Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science 317:530–533

    Article  PubMed  CAS  Google Scholar 

  15. Genève/Brasilia OMS (2004) Neuroscience of psychoactive substance use and dependence. ISBN: 92 4 259124 6

  16. Pessiglione M, Seymour B, Flandin G, et al (2006) Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 442:1042–1045

    Article  PubMed  CAS  Google Scholar 

  17. Redish AD, Jensen S, Johnson A (2008) A unified framework for addiction: vulnerabilities in the decision process. Behav Brain Sci 31:415–437 (Discussion 437–487)

    PubMed  Google Scholar 

  18. Saal D, Dong Y, Bonci A, Malenka RC (2003) Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37:577–582

    Article  PubMed  CAS  Google Scholar 

  19. Schultz W (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80:1–27

    PubMed  CAS  Google Scholar 

  20. Schultz W, Dickinson A (2000) Neuronal coding of prediction errors. Annu Rev Neurosci 23:473–500

    Article  PubMed  CAS  Google Scholar 

  21. Stipanovich A, Valjent E, Matamales M, et al (2008) A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 453:879–884

    Article  PubMed  CAS  Google Scholar 

  22. Ungless MA, Whistler JL, Malenka RC, Bonci A (2001) Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411:583–587

    Article  PubMed  CAS  Google Scholar 

  23. Waelti P, Dickinson A, Schultz W (2001) Dopamine responses comply with basic assumptions of formal learning theory. Nature 412:43–48

    Article  PubMed  CAS  Google Scholar 

  24. Zullino DLC (2008) Addiction: le côté obscur de l’apprentissage. Conférence Jeantet: Genève

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Correspondence to C. Lüscher.

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Balland, B., Lüscher, C. L’addiction: lorsque l’emballement des mécanismes d’apprentissage conduit à la perte du libre arbitre. Psychiatr Sci Hum Neurosci 7, 35–42 (2009). https://doi.org/10.1007/s11836-009-0079-1

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  • DOI: https://doi.org/10.1007/s11836-009-0079-1

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