Résumé
La recherche des anticorps anti-gliadines natives a été discréditée dans le diagnostic sérologique de la maladie coeliaque par le manque de sensibilité et de spécificité des techniques. Cette étude a pour but d’évaluer de nouvelles trousses utilisant des peptides de gliadine déamidée et de les comparer aux tests basés sur la gliadine native. Le dosage des anticorps anti-gliadines déamidées paraît être la méthode de choix pour sa plus grande spécificité face aux anticorps anti-gliadines natives dans le diagnostic différentiel de la maladie coeliaque.
Abstract
The role of anti-gliadin antibodies was greatly reduced in the diagnosis of celiac disease because of their lack of sensitivity and specificity. We evaluated the specificity of different anti-deamidated gliadin antibodies ELISA in comparison with conventional anti-native gliadin kits. Our study assessed the superiority, in terms of specificity, of anti-deamidated gliadin antibodies, over the conventional antigliadin antibodies for the differential diagnosis of celiac disease.
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Lutteri, L., Sagot, C. & Chapelle, J.P. Les anticorps anti-gliadines déamidées: nouvelles avancées dans le diagnostic sérologique de la maladie coeliaque. Bio trib. mag. 34, 16–21 (2010). https://doi.org/10.1007/s11834-010-0006-8
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DOI: https://doi.org/10.1007/s11834-010-0006-8