Résumé
Le syndrome métabolique (SMet) est un phénotype courant qui se manifeste chez quelque 24 % de la population des États-Unis. Il est associé à un risque accru de diabète de type 2 et de la maladie cardiovasculaire. Même s’il n’existe pas de définition universellement acceptée pour le SMet, les sujets atteints présentent un assemblement de traits, y compris l’obésité abdominale, l’hypertension artérielle, la dyslipidémie et la dysglycémie. Récemment, un intérêt considérable s’est manifesté pour la contribution génétique potentielle au SMet. À présent, il n’existe pas de réplication invariable de gène unique ou de groupes de gènes pour le SMet chez différentes populations, probablement à cause de l’interaction complexe entre gène et environnement nécessaire à la manifestation de ce génotype. Nous passons en revue les études effectuées sur la contribution génétique au SMet.
Abstract
Metabolic syndrome (MetS) is a common phenotype, affecting about 24 % of the US population. It is associated with an increased risk for type 2 diabetes and cardiovascular disease. Although there is no universally accepted definition for MetS, affected individuals commonly have a cluster of features, including abdominal obesity, hypertension, dyslipidemia, and dysglycemia. Recently, there has been extensive interest in potential genetic contributions to MetS. At present, no single gene or cluster of genes has been consistently replicated for MetS among different populations, likely due to the complex interplay between gene and environment necessary for expression of this phenotype. We review recent studies regarding the genetic contributions to MetS.
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Tisha, J., Lahiry, P., Pollex, R.L. et al. Génétique du syndrome métabolique. Bio trib. mag. 30, 25–32 (2009). https://doi.org/10.1007/s11834-009-0110-9
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DOI: https://doi.org/10.1007/s11834-009-0110-9